SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 11 LEU A  13
LEU A  98
HIS A 103
ALA A 102
PHE A 105
 None
None
HEM  A1270 ( 3.6A)
None
None
 1.23A 1cmaA-2xvxA:
undetectable
1cmaB-2xvxA:
undetectable		 1cmaA-2xvxA:
18.47
1cmaB-2xvxA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		4 / 5 VAL A 117
GLY A 118
VAL A  84
TRP A 257
 SO4  A1272 (-4.4A)
None
None
None
 1.12A 1tkqB-2xvxA:
undetectable		 1tkqB-2xvxA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		4 / 7 PRO A 148
LEU A 179
GLY A 181
LEU A 196
 None
 0.83A 1ya4B-2xvxA:
undetectable		 1ya4B-2xvxA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 11 VAL A 180
GLY A 153
THR A  89
ILE A  90
THR A 156
 None
NA  A1288 (-3.6A)
NA  A1288 ( 3.6A)
None
SO4  A1271 (-2.8A)
 1.11A 2f9wA-2xvxA:
3.6
2f9wB-2xvxA:
2.8		 2f9wA-2xvxA:
21.89
2f9wB-2xvxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 12 PRO A 140
ALA A 141
ALA A 217
ALA A 222
THR A 230
 CL  A1287 ( 4.8A)
CL  A1287 (-4.0A)
None
None
None
 1.32A 2x2nA-2xvxA:
undetectable		 2x2nA-2xvxA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 12 LEU A 233
VAL A 198
PRO A 148
VAL A 204
ILE A 238
 None
GOL  A1281 (-4.0A)
None
None
None
 0.96A 3cyxA-2xvxA:
undetectable		 3cyxA-2xvxA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 10 LEU A 233
VAL A 198
PRO A 148
VAL A 204
ILE A 238
 None
GOL  A1281 (-4.0A)
None
None
None
 0.95A 3oxwD-2xvxA:
undetectable		 3oxwD-2xvxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		3 / 3 TYR A 170
THR A 125
GLU A 133
 None
 0.75A 4df3A-2xvxA:
undetectable		 4df3A-2xvxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		3 / 3 TYR A 170
THR A 125
GLU A 133
 None
 0.69A 4df3B-2xvxA:
undetectable		 4df3B-2xvxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		4 / 8 PHE A 151
ALA A 134
LEU A 174
LEU A 171
 None
 0.91A 4ejgB-2xvxA:
undetectable		 4ejgB-2xvxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		4 / 7 GLU A  23
GLU A  22
GLY A 214
ARG A 218
 None
None
GOL  A1284 ( 3.1A)
None
 1.02A 4fgzA-2xvxA:
2.1		 4fgzA-2xvxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		4 / 4 HIS A 216
GLU A  94
HIS A  88
LEU A  28
 CO2  A1286 ( 3.3A)
GOL  A1277 (-4.5A)
SO4  A1273 (-4.4A)
None
 1.33A 4m2rA-2xvxA:
undetectable		 4m2rA-2xvxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 11 LEU A 209
LEU A 167
GLU A 133
ALA A 134
LEU A 135
 NA  A1288 ( 4.9A)
None
None
None
None
 1.18A 4wg0D-2xvxA:
undetectable
4wg0E-2xvxA:
undetectable
4wg0F-2xvxA:
undetectable		 4wg0D-2xvxA:
5.62
4wg0E-2xvxA:
5.62
4wg0F-2xvxA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 9 ALA A  47
LEU A 112
LEU A  13
LEU A  71
ARG A  45
 None
None
None
None
SO4  A1274 (-2.8A)
 1.27A 4x30A-2xvxA:
undetectable		 4x30A-2xvxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 12 ILE A 122
ILE A  90
ASP A 161
ILE A 162
VAL A 180
 None
 0.94A 5uvmB-2xvxA:
undetectable		 5uvmB-2xvxA:
16.85