SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A  55
ILE A  15
GLY A  51
GLY A 114
VAL A  72
 None
NDP  A1173 (-4.4A)
NDP  A1173 (-3.4A)
NDP  A1173 (-3.1A)
None
 1.08A 2okcA-2xw7A:
undetectable		 2okcA-2xw7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A  55
ILE A  15
GLY A  51
GLY A 114
VAL A  72
 None
NDP  A1173 (-4.4A)
NDP  A1173 (-3.4A)
NDP  A1173 (-3.1A)
None
 1.07A 2okcB-2xw7A:
undetectable		 2okcB-2xw7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TRP A 152
GLU A 151
SER A 150
VAL A 122
 None
 1.29A 3jx1A-2xw7A:
undetectable
3jx1B-2xw7A:
undetectable		 3jx1A-2xw7A:
18.14
3jx1B-2xw7A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 TRP A 152
GLU A 151
SER A 150
VAL A 122
 None
 1.32A 3n61A-2xw7A:
undetectable
3n61B-2xw7A:
undetectable		 3n61A-2xw7A:
18.38
3n61B-2xw7A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TRP A 152
GLU A 151
SER A 150
VAL A 122
 None
 1.25A 3nlyA-2xw7A:
undetectable
3nlyB-2xw7A:
undetectable		 3nlyA-2xw7A:
18.14
3nlyB-2xw7A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TRP A 152
GLU A 151
SER A 150
VAL A 122
 None
 1.28A 3rqlA-2xw7A:
undetectable
3rqlB-2xw7A:
undetectable		 3rqlA-2xw7A:
18.14
3rqlB-2xw7A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TRP A 152
GLU A 151
SER A 150
VAL A 122
 None
 1.26A 4capA-2xw7A:
undetectable
4capB-2xw7A:
undetectable		 4capA-2xw7A:
18.14
4capB-2xw7A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TRP A 152
GLU A 151
SER A 150
VAL A 122
 None
 1.29A 4d32A-2xw7A:
undetectable
4d32B-2xw7A:
undetectable		 4d32A-2xw7A:
18.14
4d32B-2xw7A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A  66
TRP A  64
ILE A  79
ASP A 116
GLY A  51
 None
None
None
NDP  A1173 (-2.8A)
NDP  A1173 (-3.4A)
 1.09A 4hfpB-2xw7A:
undetectable		 4hfpB-2xw7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASN A 160
PRO A  35
GLY A  37
ASP A  33
 None
 1.00A 4n48B-2xw7A:
undetectable		 4n48B-2xw7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 108
HIS A  -1
LYS A 107
 None
 0.93A 4qzuD-2xw7A:
undetectable		 4qzuD-2xw7A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 102
VAL A   1
THR A   3
ILE A 127
ASP A 128
 None
 1.15A 4uuuA-2xw7A:
undetectable
4uuuB-2xw7A:
undetectable		 4uuuA-2xw7A:
26.32
4uuuB-2xw7A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 102
VAL A   1
THR A   3
ILE A 127
ASP A 128
 None
 1.15A 4uuuB-2xw7A:
undetectable		 4uuuB-2xw7A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TRP A 152
GLU A 151
SER A 150
VAL A 122
 None
 1.26A 4v3yA-2xw7A:
undetectable
4v3yB-2xw7A:
undetectable		 4v3yA-2xw7A:
18.14
4v3yB-2xw7A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 SER A 150
VAL A 122
TRP A 152
GLU A 151
 None
 1.24A 5uo7A-2xw7A:
undetectable
5uo7B-2xw7A:
undetectable		 5uo7A-2xw7A:
18.14
5uo7B-2xw7A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2xw7 DIHYDROFOLATE
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  73
VAL A  49
LEU A 100
VAL A 111
 NDP  A1173 (-4.0A)
None
None
None
 0.95A 5x7zA-2xw7A:
undetectable		 5x7zA-2xw7A:
23.28