SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 THR F 587
THR F 588
PRO F 586
 None
 0.84A 1a7yA-2xwbF:
undetectable		 1a7yA-2xwbF:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 0.96A 1d1gA-2xwbF:
undetectable		 1d1gA-2xwbF:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.00A 1d1gB-2xwbF:
undetectable		 1d1gB-2xwbF:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 TRP B1605
ARG B1569
THR B1604
 None
 0.94A 1df7A-2xwbB:
undetectable		 1df7A-2xwbB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 0.98A 1dhiB-2xwbF:
undetectable		 1dhiB-2xwbF:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 0.98A 1draB-2xwbF:
undetectable		 1draB-2xwbF:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.00A 1drbB-2xwbF:
undetectable		 1drbB-2xwbF:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 PRO F 373
LEU F 334
VAL F 287
TYR F 289
LEU F 361
 None
 1.31A 1fkpA-2xwbF:
undetectable		 1fkpA-2xwbF:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 THR F 588
PRO F 586
THR F 587
 None
 0.86A 1i3wE-2xwbF:
undetectable		 1i3wE-2xwbF:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 THR F 587
THR F 588
PRO F 586
 None
 0.83A 1i3wF-2xwbF:
undetectable		 1i3wF-2xwbF:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 THR F 588
PRO F 586
THR F 587
 None
 0.85A 1mnvD-2xwbF:
undetectable		 1mnvD-2xwbF:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 THR F 587
THR F 588
PRO F 586
 None
 0.79A 1mnvD-2xwbF:
undetectable		 1mnvD-2xwbF:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 GLN F 471
ILE F 474
ALA F 472
VAL F 691
ALA F 553
 None
 1.00A 1n4hA-2xwbF:
undetectable		 1n4hA-2xwbF:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 4 HIS B1327
VAL B 949
THR B 883
LEU B1488
 None
 1.26A 1oq5A-2xwbB:
undetectable		 1oq5A-2xwbB:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 THR F 587
THR F 588
PRO F 586
 None
 0.82A 1qfiA-2xwbF:
undetectable		 1qfiA-2xwbF:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 GLU B1199
ASN B1207
TRP B1233
 None
 1.29A 1r15C-2xwbB:
undetectable		 1r15C-2xwbB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 GLU B1199
ASN B1207
TRP B1233
 None
 1.26A 1r15D-2xwbB:
undetectable		 1r15D-2xwbB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 GLU B1199
ASN B1207
TRP B1233
 None
 1.28A 1r15E-2xwbB:
undetectable		 1r15E-2xwbB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 GLU B1199
ASN B1207
TRP B1233
 None
 1.25A 1r15F-2xwbB:
undetectable		 1r15F-2xwbB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.05A 1ra3A-2xwbF:
undetectable		 1ra3A-2xwbF:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 0.99A 1rb2A-2xwbF:
undetectable		 1rb2A-2xwbF:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.00A 1rd7A-2xwbF:
undetectable		 1rd7A-2xwbF:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.01A 1rx2A-2xwbF:
undetectable		 1rx2A-2xwbF:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 0.97A 1rx7A-2xwbF:
undetectable		 1rx7A-2xwbF:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 7 ILE B 958
LEU B1276
THR B 924
LEU B 925
 None
 0.92A 1v55A-2xwbB:
2.2
1v55J-2xwbB:
undetectable		 1v55A-2xwbB:
20.77
1v55J-2xwbB:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 6 LEU B1056
GLY B 989
ILE B1103
HIS B1104
 None
 0.77A 1yajF-2xwbB:
undetectable		 1yajF-2xwbB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 5 SER F 253
SER F 255
THR F 328
ASN F 368
 MG  F1742 (-2.0A)
MG  F1742 (-2.0A)
MG  F1742 (-2.1A)
None
 0.49A 1yvpA-2xwbF:
9.5		 1yvpA-2xwbF:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 6 SER F 253
SER F 255
THR F 328
ASN F 368
 MG  F1742 (-2.0A)
MG  F1742 (-2.0A)
MG  F1742 (-2.1A)
None
 0.53A 1yvpB-2xwbF:
9.3		 1yvpB-2xwbF:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 12 THR B1247
ILE B1108
VAL B1102
ILE B 994
LEU B1056
 None
 1.15A 1z9hD-2xwbB:
2.2		 1z9hD-2xwbB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 ILE B1366
PHE B1439
LEU B1399
ILE B1407
 None
 0.94A 2azxA-2xwbB:
undetectable		 2azxA-2xwbB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.01A 2drcB-2xwbF:
undetectable		 2drcB-2xwbF:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 ILE B 958
LEU B1276
THR B 924
LEU B 925
 None
 0.84A 2einA-2xwbB:
1.7
2einJ-2xwbB:
undetectable		 2einA-2xwbB:
20.77
2einJ-2xwbB:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 LYS B 857
GLY B1518
PRO B1517
 None
 0.76A 2hreB-2xwbB:
undetectable		 2hreB-2xwbB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 7 SER F 253
SER F 255
THR F 328
ASN F 368
 MG  F1742 (-2.0A)
MG  F1742 (-2.0A)
MG  F1742 (-2.1A)
None
 0.58A 2i91A-2xwbF:
9.1		 2i91A-2xwbF:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 7 SER F 253
SER F 255
THR F 328
ASN F 368
 MG  F1742 (-2.0A)
MG  F1742 (-2.0A)
MG  F1742 (-2.1A)
None
 0.58A 2i91B-2xwbF:
8.7		 2i91B-2xwbF:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 7 VAL B 828
VAL B 903
ASP B 901
VAL B 890
 None
 0.88A 2qbnA-2xwbB:
undetectable		 2qbnA-2xwbB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 7 ALA B1002
ASP B1007
LEU B1006
ARG B1020
 None
 0.79A 2uyqA-2xwbB:
undetectable		 2uyqA-2xwbB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 THR B1302
VAL B1322
LEU B1278
VAL B1310
 None
 0.84A 2zujA-2xwbB:
undetectable		 2zujA-2xwbB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 ILE B 958
LEU B1276
THR B 924
LEU B 925
 None
 0.93A 3abkA-2xwbB:
2.3
3abkJ-2xwbB:
undetectable		 3abkA-2xwbB:
20.77
3abkJ-2xwbB:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 7 ILE B 958
LEU B1276
THR B 924
LEU B 925
 None
 0.94A 3ag3A-2xwbB:
3.7
3ag3J-2xwbB:
undetectable		 3ag3A-2xwbB:
20.77
3ag3J-2xwbB:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 PRO B1183
LEU B1184
ARG B1179
 None
 0.84A 3aqiA-2xwbB:
undetectable		 3aqiA-2xwbB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 PRO B1183
LEU B1184
ARG B1179
 None
 0.55A 3aqiB-2xwbB:
undetectable		 3aqiB-2xwbB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
COMPLEMENT FACTOR B
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLY F 371
ASP B1520
SER B1586
 None
 0.69A 3brfA-2xwbF:
undetectable		 3brfA-2xwbF:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.02A 3clbA-2xwbF:
2.3		 3clbA-2xwbF:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.00A 3drcB-2xwbF:
undetectable		 3drcB-2xwbF:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 GLU B1411
SER B 873
VAL B 828
 None
 0.63A 3eeoA-2xwbB:
undetectable		 3eeoA-2xwbB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 8 GLY F 488
ILE F 555
VAL F 514
VAL F 516
 None
 0.78A 3fi0I-2xwbF:
undetectable		 3fi0I-2xwbF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 THR B 956
THR B1302
GLU F 159
LEU B1276
ILE B1285
 None
 1.47A 3gwxB-2xwbB:
undetectable		 3gwxB-2xwbB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.03A 3hbbC-2xwbF:
undetectable		 3hbbC-2xwbF:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 LEU B 813
PRO B 814
LEU B 907
 None
 0.54A 3hcrA-2xwbB:
undetectable		 3hcrA-2xwbB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 ARG F 113
GLU F  85
TYR F 164
 None
 0.82A 3k37B-2xwbF:
undetectable		 3k37B-2xwbF:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 11 GLU B1411
ASP B1413
LEU B1422
ILE B1407
SER B 871
 None
 1.34A 3ko0E-2xwbB:
undetectable
3ko0F-2xwbB:
undetectable
3ko0G-2xwbB:
0.0
3ko0H-2xwbB:
undetectable		 3ko0E-2xwbB:
8.24
3ko0F-2xwbB:
8.24
3ko0G-2xwbB:
8.24
3ko0H-2xwbB:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 6 PHE B1251
TYR B1059
THR B 997
VAL B1000
 None
 1.18A 3lb3A-2xwbB:
undetectable		 3lb3A-2xwbB:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 7 ARG F 671
SER F 475
ILE F 512
PHE F 503
 None
 1.09A 3ln1C-2xwbF:
undetectable		 3ln1C-2xwbF:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 ASP F 673
SER F 609
ARG F 705
 None
 0.98A 3loqA-2xwbF:
2.1		 3loqA-2xwbF:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 9 ILE B 866
GLN B 805
ASP B 901
PHE B 807
LEU B 838
 None
 1.22A 3mjrA-2xwbB:
undetectable		 3mjrA-2xwbB:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.01A 3tqbA-2xwbF:
undetectable		 3tqbA-2xwbF:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 GLN B1248
PHE B1124
TYR B1059
 None
 0.98A 3ucjA-2xwbB:
undetectable		 3ucjA-2xwbB:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
COMPLEMENT FACTOR B
(Homo
sapiens;
Homo
sapiens) 		4 / 5 TYR F 664
SER B1283
ASP F 666
ILE F 622
 None
 1.00A 3uj7B-2xwbF:
undetectable		 3uj7B-2xwbF:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 0.99A 4dfrB-2xwbF:
undetectable		 4dfrB-2xwbF:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 6 SER F 185
ASP F 422
ARG F 683
GLU F 596
 None
 1.08A 4eysA-2xwbF:
3.2		 4eysA-2xwbF:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 SER F 342
TYR F 338
PRO F 349
 None
 0.87A 4k8cA-2xwbF:
undetectable		 4k8cA-2xwbF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 SER F 342
TYR F 338
PRO F 349
 None
 0.90A 4kahA-2xwbF:
undetectable		 4kahA-2xwbF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 SER F 342
TYR F 338
PRO F 349
 None
 0.89A 4kahB-2xwbF:
undetectable		 4kahB-2xwbF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 SER F 342
TYR F 338
PRO F 349
 None
 0.87A 4kanA-2xwbF:
undetectable		 4kanA-2xwbF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 SER F 342
TYR F 338
PRO F 349
 None
 0.86A 4kanB-2xwbF:
undetectable		 4kanB-2xwbF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 SER F 342
TYR F 338
PRO F 349
 None
 0.91A 4kbeA-2xwbF:
undetectable		 4kbeA-2xwbF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 SER F 342
TYR F 338
PRO F 349
 None
 0.90A 4kbeB-2xwbF:
undetectable		 4kbeB-2xwbF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 ARG F 521
LEU F 523
GLU F 524
 None
 0.60A 4l3gF-2xwbF:
undetectable		 4l3gF-2xwbF:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 SER F 342
TYR F 338
PRO F 349
 None
 0.86A 4lbgA-2xwbF:
undetectable		 4lbgA-2xwbF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 SER F 342
TYR F 338
PRO F 349
 None
 0.87A 4lbgB-2xwbF:
undetectable		 4lbgB-2xwbF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 6 GLU F 595
GLU F 190
ASN F 423
ARG F 683
 None
 1.36A 4ntxA-2xwbF:
1.7
4ntxC-2xwbF:
undetectable		 4ntxA-2xwbF:
20.84
4ntxC-2xwbF:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 ALA F 307
ILE F 217
LEU F 213
ILE F 246
THR F 311
 None
 1.05A 4pstA-2xwbF:
undetectable		 4pstA-2xwbF:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 8 LEU F 314
VAL F 297
TYR F 284
LEU F 248
 None
 1.17A 4q0bA-2xwbF:
2.3		 4q0bA-2xwbF:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 VAL F 514
ILE F 474
GLY F 675
ASP F 551
ILE F 555
 None
 0.98A 4q5mA-2xwbF:
undetectable		 4q5mA-2xwbF:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 ASP F 364
ASP F 251
ASN F 329
 MG  F1742 ( 4.2A)
MG  F1742 ( 4.5A)
None
 0.83A 4q5mA-2xwbF:
undetectable		 4q5mA-2xwbF:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		3 / 3 LEU B 981
PHE B1015
ILE B 982
 None
 0.77A 5dzk1-2xwbB:
undetectable
5dzkF-2xwbB:
undetectable
5dzkM-2xwbB:
undetectable		 5dzk1-2xwbB:
1.72
5dzkF-2xwbB:
14.34
5dzkM-2xwbB:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 12 ALA B1173
ALA B1170
VAL B1167
LEU B1174
GLY B1151
 None
 1.29A 5igpA-2xwbB:
undetectable		 5igpA-2xwbB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 5 TYR B1523
ILE B1547
LEU B1585
GLY B1584
 None
 0.95A 5kmdC-2xwbB:
undetectable
5kmdD-2xwbB:
1.6		 5kmdC-2xwbB:
14.67
5kmdD-2xwbB:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 6 LEU B1066
ILE B 994
THR B 997
MET B1107
 None
 1.37A 5ljeA-2xwbB:
undetectable		 5ljeA-2xwbB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 ARG B1020
GLU B1018
GLY B1022
LEU B1024
 None
 0.99A 5sxqA-2xwbB:
undetectable		 5sxqA-2xwbB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 ARG B1020
GLU B1018
GLY B1022
LEU B1024
 None
 0.98A 5sxqB-2xwbB:
undetectable		 5sxqB-2xwbB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 ARG B1020
GLU B1018
GLY B1022
LEU B1024
 None
 0.97A 5sxtA-2xwbB:
undetectable		 5sxtA-2xwbB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 ARG B1020
GLU B1018
GLY B1022
LEU B1024
 None
 0.95A 5sxtB-2xwbB:
undetectable		 5sxtB-2xwbB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 ARG B1020
GLU B1018
GLY B1022
LEU B1024
 None
 0.99A 5syjA-2xwbB:
undetectable		 5syjA-2xwbB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 ARG B1020
GLU B1018
GLY B1022
LEU B1024
 None
 0.99A 5syjB-2xwbB:
undetectable		 5syjB-2xwbB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 7 ARG B1405
PHE B1439
LEU B1364
SER B1384
 None
 1.24A 5uxcA-2xwbB:
undetectable		 5uxcA-2xwbB:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 GLY F  87
ASP F  83
GLY F 144
ASN F 142
ILE F 145
 None
 1.00A 5vopA-2xwbF:
undetectable		 5vopA-2xwbF:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 GLY F  87
ASP F  83
GLY F 144
ASN F 142
ILE F 145
 None
 1.10A 5vopB-2xwbF:
undetectable		 5vopB-2xwbF:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 5 TYR B1239
TYR B1240
GLY B1241
GLY B1242
 None
 1.01A 5x7pA-2xwbB:
2.6		 5x7pA-2xwbB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 8 VAL B 817
LEU B 907
LEU B 813
ILE B 878
 None
 0.92A 5y1yA-2xwbB:
undetectable		 5y1yA-2xwbB:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 6 TYR F 278
VAL F 280
ILE F 217
GLU F 218
 None
 0.96A 5z3jA-2xwbF:
undetectable		 5z3jA-2xwbF:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 12 GLN B1261
VAL B1253
TYR B1239
THR B1250
LEU B 981
 None
 1.31A 6ak3A-2xwbB:
undetectable		 6ak3A-2xwbB:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 12 MET B1385
ILE B1383
LEU B1381
PHE B1439
LEU B1341
 None
 1.08A 6b52A-2xwbB:
undetectable		 6b52A-2xwbB:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 2xwb COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 HIS F 501
ASP F 551
GLY F 672
SER F 674
VAL F 696
 None
 0.72A 6c2mC-2xwbF:
4.3		 6c2mC-2xwbF:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		4 / 6 TYR B1370
TYR B1461
GLU B1465
LYS B1338
 None
 1.49A 6d8pA-2xwbB:
0.0		 6d8pA-2xwbB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 12 ASP B1200
GLU B1199
LEU B1180
ALA B1192
LEU B1218
 None
 1.05A 6ew0B-2xwbB:
undetectable		 6ew0B-2xwbB:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 12 ASP B1200
GLU B1199
LEU B1180
ALA B1192
LEU B1218
 None
 1.05A 6ew0D-2xwbB:
undetectable		 6ew0D-2xwbB:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 12 ASP B1200
GLU B1199
LEU B1180
ALA B1192
LEU B1218
 None
 1.05A 6ew0H-2xwbB:
undetectable		 6ew0H-2xwbB:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens) 		5 / 12 ASP B1200
GLU B1199
LEU B1180
ALA B1192
LEU B1218
 None
 1.05A 6ew0I-2xwbB:
undetectable		 6ew0I-2xwbB:
6.94