SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2xwg SORTASE
(Actinomyces
oris) 		4 / 6 LEU A 167
LEU A 201
LEU A 216
LEU A 230
 None
 0.94A 1errA-2xwgA:
undetectable		 1errA-2xwgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 2xwg SORTASE
(Actinomyces
oris) 		4 / 7 MET A 149
TYR A 118
HIS A 184
HIS A 171
 None
 1.37A 2bytA-2xwgA:
undetectable		 2bytA-2xwgA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 2xwg SORTASE
(Actinomyces
oris) 		4 / 7 MET A 149
TYR A 118
HIS A 184
HIS A 171
 None
 1.37A 2bytD-2xwgA:
undetectable		 2bytD-2xwgA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2xwg SORTASE
(Actinomyces
oris) 		3 / 3 ARG A 112
GLY A 194
PRO A 195
 None
 0.60A 2hreD-2xwgA:
undetectable		 2hreD-2xwgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2xwg SORTASE
(Actinomyces
oris) 		3 / 3 ALA A 156
GLY A 183
SER A 199
 None
 0.59A 2ivuA-2xwgA:
undetectable		 2ivuA-2xwgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2xwg SORTASE
(Actinomyces
oris) 		4 / 5 LEU A 277
LEU A 185
CYH A 266
THR A 267
 None
 1.34A 2oaxD-2xwgA:
undetectable		 2oaxD-2xwgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 2xwg SORTASE
(Actinomyces
oris) 		3 / 3 ASP A 214
ASN A 215
SER A 208
 None
 0.98A 3lslA-2xwgA:
undetectable
3lslD-2xwgA:
undetectable		 3lslA-2xwgA:
21.54
3lslD-2xwgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 2xwg SORTASE
(Actinomyces
oris) 		3 / 3 SER A 208
ASP A 214
ASN A 215
 None
 0.95A 3lslA-2xwgA:
undetectable
3lslD-2xwgA:
undetectable		 3lslA-2xwgA:
21.54
3lslD-2xwgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2xwg SORTASE
(Actinomyces
oris) 		4 / 7 PRO A 191
LEU A 263
ILE A 169
MET A 155
 None
 1.00A 3u5jA-2xwgA:
undetectable		 3u5jA-2xwgA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2xwg SORTASE
(Actinomyces
oris) 		5 / 9 PRO A 191
VAL A 261
LEU A 263
ILE A 169
MET A 155
 None
 1.46A 4c66A-2xwgA:
undetectable		 4c66A-2xwgA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 2xwg SORTASE
(Actinomyces
oris) 		3 / 3 ILE A 160
PRO A 161
ILE A 163
 None
 0.45A 5hw8F-2xwgA:
undetectable		 5hw8F-2xwgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 2xwg SORTASE
(Actinomyces
oris) 		4 / 5 GLU A 248
VAL A 244
LEU A 277
HIS A 198
 None
 1.44A 6dyoA-2xwgA:
undetectable		 6dyoA-2xwgA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2xwg SORTASE
(Actinomyces
oris) 		3 / 3 THR A 197
GLU A 123
ASN A 119
 None
 0.69A 6nj9K-2xwgA:
undetectable		 6nj9K-2xwgA:
18.29