SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2xwl 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 211
PRO A 208
LEU A  16
ARG A  20
 None
 1.41A 2qd2A-2xwlA:
2.9		 2qd2A-2xwlA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 2xwl 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  58
SER A  74
GLY A  75
ALA A  86
SER A  61
 None
 1.17A 3mg02-2xwlA:
undetectable
3mg0V-2xwlA:
undetectable		 3mg02-2xwlA:
20.97
3mg0V-2xwlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2xwl 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  58
SER A  74
GLY A  75
ALA A  86
SER A  61
 None
 1.18A 3mg0N-2xwlA:
undetectable		 3mg0N-2xwlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2xwl 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A  32
ASP A 210
ALA A 214
VAL A 217
 None
 0.92A 4zbqA-2xwlA:
undetectable		 4zbqA-2xwlA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2xwl 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 HIS A  99
VAL A 114
THR A 106
ALA A 202
PRO A 200
 None
 1.22A 5tt3C-2xwlA:
undetectable		 5tt3C-2xwlA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2xwl 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 HIS A  99
VAL A 114
THR A 106
ALA A 202
PRO A 200
 None
 1.30A 5tt3C-2xwlA:
undetectable		 5tt3C-2xwlA:
19.92