SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 LEU B 610
LEU B 613
VAL B 570
SER B 599
PHE B 596
 None
 1.11A 1dfoA-2xwuB:
undetectable		 1dfoA-2xwuB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 LEU B 610
LEU B 613
VAL B 570
SER B 599
PHE B 596
 None
 1.10A 1dfoB-2xwuB:
undetectable		 1dfoB-2xwuB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 LEU B 610
LEU B 613
VAL B 570
SER B 599
PHE B 596
 None
 1.11A 1dfoC-2xwuB:
undetectable		 1dfoC-2xwuB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 LEU B 610
LEU B 613
VAL B 570
SER B 599
PHE B 596
 None
 1.11A 1dfoD-2xwuB:
undetectable		 1dfoD-2xwuB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 10 ALA B 335
LEU B 315
ALA B 312
PHE B 333
ILE B 283
 None
 1.08A 1g5yC-2xwuB:
undetectable		 1g5yC-2xwuB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 9 LEU B 610
ILE B 640
GLY B 642
VAL B 680
ILE B 614
 None
 0.82A 1ohrB-2xwuB:
undetectable		 1ohrB-2xwuB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 8 SER B 517
LEU B 535
LEU B 590
LEU B 594
 None
 1.01A 2bfpB-2xwuB:
undetectable		 2bfpB-2xwuB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 ALA B 248
ARG B 219
ILE B 263
ALA B 262
PHE B 226
 None
 1.19A 2ejtA-2xwuB:
undetectable		 2ejtA-2xwuB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 5 ILE B 283
PRO B 284
PHE B 247
ILE B 267
 None
 0.98A 2hjhA-2xwuB:
undetectable		 2hjhA-2xwuB:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 8 THR B 479
VAL B 482
ASN B 483
ALA B 440
 None
 0.97A 2ij7C-2xwuB:
undetectable		 2ij7C-2xwuB:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 9 LEU B 610
ILE B 640
GLY B 642
VAL B 680
ILE B 614
 None
 1.06A 2r5qA-2xwuB:
undetectable		 2r5qA-2xwuB:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 9 LEU B 610
ILE B 640
GLY B 642
VAL B 680
ILE B 614
 None
 1.06A 2r5qC-2xwuB:
undetectable		 2r5qC-2xwuB:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 6 LEU B 450
LEU B 453
ILE B 495
ARG B 497
 None
 0.93A 2rlfB-2xwuB:
undetectable
2rlfC-2xwuB:
undetectable		 2rlfB-2xwuB:
3.57
2rlfC-2xwuB:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 9 ILE B 764
ALA B 721
VAL B 724
CYH B 728
 None
 0.91A 2vufB-2xwuB:
4.0		 2vufB-2xwuB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 PHE B 333
VAL B 264
VAL B 337
LEU B 367
ILE B 340
 None
 1.40A 3elzA-2xwuB:
undetectable		 3elzA-2xwuB:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 PHE B 897
LEU B 870
VAL B 869
LEU B 889
ILE B 930
 None
 1.06A 3gwxB-2xwuB:
undetectable		 3gwxB-2xwuB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 10 ALA B 312
LEU B 336
LEU B 323
LEU B 282
ILE B 283
 None
 1.04A 3r9cA-2xwuB:
undetectable		 3r9cA-2xwuB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xwu IMPORTIN13
(Homo
sapiens) 		3 / 3 PHE B 828
GLN B 876
PHE B 779
 None
 0.74A 3rv5A-2xwuB:
undetectable		 3rv5A-2xwuB:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2xwu IMPORTIN13
(Homo
sapiens) 		3 / 3 ARG B 424
PHE B 403
PRO B 404
 None
 0.58A 3zoaB-2xwuB:
undetectable		 3zoaB-2xwuB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 LEU B 324
TYR B 386
GLN B 331
ALA B 335
MET B 339
 None
 1.25A 4a83A-2xwuB:
undetectable		 4a83A-2xwuB:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 6 THR B 304
GLY B 307
ILE B 311
LEU B 293
 None
 0.97A 4ac9C-2xwuB:
undetectable		 4ac9C-2xwuB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 6 THR B 304
GLY B 307
ILE B 311
LEU B 293
 None
 1.01A 4acaC-2xwuB:
undetectable		 4acaC-2xwuB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 6 THR B 304
GLY B 307
ILE B 311
LEU B 293
 None
 1.02A 4acbC-2xwuB:
undetectable		 4acbC-2xwuB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 8 LEU B 170
VAL B 143
VAL B 147
GLN B 151
 None
 0.96A 4em2A-2xwuB:
undetectable		 4em2A-2xwuB:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 11 GLU B 622
LEU B 644
VAL B 705
ILE B 708
LEU B 727
 None
 1.50A 4k37B-2xwuB:
undetectable		 4k37B-2xwuB:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 9 HIS B 582
VAL B 572
SER B 573
VAL B 576
LEU B 577
 None
 0.93A 4qd3A-2xwuB:
undetectable		 4qd3A-2xwuB:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 11 LEU B 610
ILE B 640
GLY B 642
VAL B 680
ILE B 614
 None
 0.85A 4qgiB-2xwuB:
undetectable		 4qgiB-2xwuB:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 LEU B 610
SER B 612
LEU B 651
LEU B 601
ILE B 606
 None
 1.06A 4x1fA-2xwuB:
undetectable		 4x1fA-2xwuB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 LEU B 610
SER B 612
LEU B 651
LEU B 601
ILE B 606
 None
 1.08A 4x1gA-2xwuB:
undetectable		 4x1gA-2xwuB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 6 LEU B 598
GLU B 605
ILE B 614
PRO B 674
 None
 0.97A 4xi3C-2xwuB:
undetectable		 4xi3C-2xwuB:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 9 SER B 268
ALA B 272
LEU B 315
LEU B 282
ILE B 263
 None
 1.48A 4xtaA-2xwuB:
undetectable		 4xtaA-2xwuB:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2xwu IMPORTIN13
(Homo
sapiens) 		3 / 3 VAL B 125
THR B 121
ARG B 122
 None
 0.73A 5b2sB-2xwuB:
2.2		 5b2sB-2xwuB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2xwu IMPORTIN13
(Homo
sapiens) 		3 / 3 VAL B 125
THR B 121
ARG B 122
 None
 0.74A 5b2tB-2xwuB:
undetectable		 5b2tB-2xwuB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 7 TRP B 364
THR B 430
TYR B 365
THR B 366
 None
 1.36A 5b6iA-2xwuB:
undetectable		 5b6iA-2xwuB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 6 TRP B 364
THR B 430
TYR B 365
THR B 366
 None
 1.39A 5b6iB-2xwuB:
undetectable		 5b6iB-2xwuB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 7 ILE B  84
PHE B  61
GLY B  78
LEU B  30
 None
 0.99A 5esmA-2xwuB:
undetectable		 5esmA-2xwuB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 5 CYH B 309
ILE B 340
CYH B 343
LEU B 359
 None
 1.48A 5hrqC-2xwuB:
undetectable
5hrqD-2xwuB:
undetectable
5hrqL-2xwuB:
undetectable		 5hrqC-2xwuB:
3.04
5hrqD-2xwuB:
2.65
5hrqL-2xwuB:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 6 VAL B 548
LEU B 538
CYH B 587
LEU B 577
 None
 1.04A 5hrqB-2xwuB:
undetectable
5hrqI-2xwuB:
undetectable
5hrqJ-2xwuB:
undetectable		 5hrqB-2xwuB:
2.65
5hrqI-2xwuB:
3.04
5hrqJ-2xwuB:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 8 ILE B  84
PHE B  61
GLY B  78
LEU B  30
 None
 0.82A 5hs1A-2xwuB:
undetectable		 5hs1A-2xwuB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2xwu IMPORTIN13
(Homo
sapiens) 		3 / 3 VAL B 790
GLN B 780
CYH B 821
 None
 0.82A 5icxC-2xwuB:
undetectable
5icxF-2xwuB:
undetectable		 5icxC-2xwuB:
12.99
5icxF-2xwuB:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 4 LEU B 130
MET B 135
ILE B 109
LEU B 173
 None
 1.12A 5nfpA-2xwuB:
undetectable		 5nfpA-2xwuB:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xwu IMPORTIN13
(Homo
sapiens) 		5 / 12 TYR B 390
LEU B 393
PHE B 363
LEU B 324
LEU B 334
 None
 1.17A 5y2oA-2xwuB:
undetectable		 5y2oA-2xwuB:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 2xwu IMPORTIN13
(Homo
sapiens) 		4 / 4 VAL B 818
ALA B 822
PHE B 793
PHE B 779
 None
 1.49A 6cbdA-2xwuB:
0.3		 6cbdA-2xwuB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xwu IMPORTIN13
(Homo
sapiens) 		3 / 3 LEU B 164
GLN B 160
LYS B 224
 None
 0.88A 6exiB-2xwuB:
undetectable		 6exiB-2xwuB:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2xwu IMPORTIN13
(Homo
sapiens) 		3 / 3 LEU B 164
GLN B 160
LYS B 224
 None
 0.88A 6exiA-2xwuB:
undetectable		 6exiA-2xwuB:
6.97