SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		5 / 11 LEU A 254
ILE A 268
THR A 266
VAL A 305
THR A 231
 None
 1.41A 1tw4A-2xwxA:
undetectable		 1tw4A-2xwxA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		5 / 10 LEU A 254
ILE A 268
THR A 266
VAL A 305
THR A 231
 None
 1.42A 1tw4B-2xwxA:
0.0		 1tw4B-2xwxA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		4 / 6 ASP A 185
TYR A 128
PHE A  72
LEU A 181
 None
 1.10A 2w98A-2xwxA:
undetectable
2w98B-2xwxA:
undetectable		 2w98A-2xwxA:
23.36
2w98B-2xwxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		4 / 5 GLY A 400
ASP A 397
ARG A 398
GLN A 367
 None
 1.26A 3qx3A-2xwxA:
undetectable		 3qx3A-2xwxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		4 / 7 ASN A 258
ALA A 257
PRO A 219
ARG A 100
 None
 0.97A 3twpA-2xwxA:
undetectable		 3twpA-2xwxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		4 / 7 ASN A 258
ALA A 257
PRO A 219
ARG A 100
 None
 0.98A 3twpB-2xwxA:
undetectable		 3twpB-2xwxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		4 / 7 ASN A 258
ALA A 257
PRO A 219
ARG A 100
 None
 0.97A 3twpC-2xwxA:
undetectable		 3twpC-2xwxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		5 / 12 GLY A  33
ASN A  32
ILE A 106
GLN A 111
ASN A  47
 None
 1.26A 4pooB-2xwxA:
undetectable		 4pooB-2xwxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		5 / 12 PRO A  63
VAL A  27
ALA A  29
GLY A  48
THR A  49
 None
 1.47A 5igpA-2xwxA:
undetectable		 5igpA-2xwxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		5 / 12 VAL A  66
SER A  65
TRP A 115
GLY A  37
LEU A  93
 None
 1.15A 5ikrA-2xwxA:
undetectable		 5ikrA-2xwxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 2xwx GLCNAC-BINDING
PROTEIN A
(Vibrio
cholerae) 		3 / 3 ARG A 143
PRO A  77
TYR A 129
 None
 1.01A 5tzoB-2xwxA:
undetectable		 5tzoB-2xwxA:
18.58