SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		4 / 8 GLY A 316
THR A 267
GLY A 320
LEU A 135
 None
 0.72A 1aegA-2xxlA:
undetectable		 1aegA-2xxlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		4 / 8 HIS A 163
SER A 318
VAL A 342
GLY A 356
 None
 0.42A 1aq7A-2xxlA:
26.1		 1aq7A-2xxlA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 9 GLU A 269
SER A 318
VAL A 342
GLY A 345
GLY A 356
 NAG  A1385 (-4.0A)
None
None
None
None
 1.31A 1bcuH-2xxlA:
28.1		 1bcuH-2xxlA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		4 / 7 THR A 259
SER A 258
SER A 313
TYR A 123
 None
 1.04A 1ibgL-2xxlA:
undetectable		 1ibgL-2xxlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 GLY A 320
GLU A 338
LEU A 136
ILE A 158
ILE A 242
 None
 1.10A 1kyvA-2xxlA:
undetectable
1kyvE-2xxlA:
undetectable		 1kyvA-2xxlA:
18.99
1kyvE-2xxlA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 ILE A 242
GLY A 320
GLU A 338
LEU A 136
ILE A 158
 None
 1.12A 1kyvB-2xxlA:
undetectable
1kyvC-2xxlA:
undetectable		 1kyvB-2xxlA:
18.99
1kyvC-2xxlA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		4 / 6 PRO A 131
MET A 133
ALA A 151
GLU A 338
 None
 1.25A 1qhyA-2xxlA:
undetectable		 1qhyA-2xxlA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 8 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.04A 1v55N-2xxlA:
undetectable
1v55W-2xxlA:
undetectable		 1v55N-2xxlA:
19.17
1v55W-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		4 / 6 LEU A 244
ARG A 156
MET A 372
LEU A 226
 None
 1.06A 2dysN-2xxlA:
undetectable
2dysW-2xxlA:
undetectable		 2dysN-2xxlA:
19.17
2dysW-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		4 / 7 PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.10A 2eikA-2xxlA:
undetectable
2eikJ-2xxlA:
undetectable		 2eikA-2xxlA:
19.17
2eikJ-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 8 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.07A 2einA-2xxlA:
undetectable
2einJ-2xxlA:
undetectable		 2einA-2xxlA:
19.17
2einJ-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		6 / 12 ILE A 211
LEU A 168
GLY A 167
ILE A 224
ALA A 162
HIS A 163
 None
 1.38A 2fk8A-2xxlA:
undetectable		 2fk8A-2xxlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 10 TYR A 215
HIS A 212
ALA A 162
ALA A 225
TYR A 364
 None
 1.42A 2r2vC-2xxlA:
undetectable
2r2vF-2xxlA:
undetectable
2r2vG-2xxlA:
undetectable		 2r2vC-2xxlA:
4.99
2r2vF-2xxlA:
4.99
2r2vG-2xxlA:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 10 GLY A 150
ALA A 134
ILE A 239
ILE A 153
ILE A 175
 None
 0.94A 2r5qD-2xxlA:
undetectable		 2r5qD-2xxlA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 8 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.10A 3abkA-2xxlA:
undetectable
3abkJ-2xxlA:
undetectable		 3abkA-2xxlA:
19.17
3abkJ-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 8 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.06A 3abmN-2xxlA:
undetectable
3abmW-2xxlA:
undetectable		 3abmN-2xxlA:
19.17
3abmW-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 8 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.08A 3asoN-2xxlA:
undetectable
3asoW-2xxlA:
undetectable		 3asoN-2xxlA:
19.17
3asoW-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 GLY A 308
GLY A 307
GLY A 306
SER A 313
TYR A 294
 None
 0.96A 4ey6A-2xxlA:
undetectable		 4ey6A-2xxlA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		4 / 7 ILE A 257
LEU A 322
GLY A 340
PHE A 339
 None
 0.91A 4iqqA-2xxlA:
undetectable		 4iqqA-2xxlA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 ALA A 134
LEU A 226
GLY A 112
LEU A 244
PHE A 104
 None
 1.16A 4kykA-2xxlA:
undetectable
4kykB-2xxlA:
undetectable		 4kykA-2xxlA:
18.25
4kykB-2xxlA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 9 PRO A 321
LEU A 136
ILE A 341
LEU A 159
THR A 160
 None
 1.19A 4x3mB-2xxlA:
undetectable		 4x3mB-2xxlA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		3 / 3 PHE A  87
ILE A  51
ASP A  38
 None
 0.74A 5cswA-2xxlA:
undetectable		 5cswA-2xxlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		3 / 3 PHE A  87
ILE A  51
ASP A  38
 None
 0.72A 5cswB-2xxlA:
undetectable		 5cswB-2xxlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 ALA A 161
GLU A 338
GLY A 340
GLU A 363
TYR A 260
 None
 1.20A 5n5dA-2xxlA:
undetectable		 5n5dA-2xxlA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		4 / 7 LEU A 354
GLY A 356
GLY A 306
ALA A 293
 None
 0.73A 5o96C-2xxlA:
undetectable		 5o96C-2xxlA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 10 HIS A  96
ASN A  97
ILE A 153
ILE A 158
LEU A 227
 None
 1.31A 5vkqC-2xxlA:
undetectable
5vkqD-2xxlA:
undetectable		 5vkqC-2xxlA:
12.47
5vkqD-2xxlA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 8 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.18A 5zcpN-2xxlA:
undetectable
5zcpW-2xxlA:
undetectable		 5zcpN-2xxlA:
19.17
5zcpW-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		6 / 7 GLY A 266
GLY A 316
GLY A 320
PRO A 321
GLY A 150
GLY A 149
 None
 1.32A 6ag0A-2xxlA:
undetectable		 6ag0A-2xxlA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		3 / 3 PRO A  44
SER A  46
SER A  47
 None
 0.51A 6bpyA-2xxlA:
undetectable		 6bpyA-2xxlA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 GLY A 150
ALA A 134
ILE A 239
ILE A 153
ILE A 175
 None
 0.95A 6difB-2xxlA:
undetectable		 6difB-2xxlA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B
(Drosophila
melanogaster) 		4 / 7 VAL A 233
GLY A 340
ARG A 176
ALA A 151
 None
 0.86A 6hd6B-2xxlA:
undetectable		 6hd6B-2xxlA:
12.26