SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B
(Homo
sapiens) 		4 / 7 ILE A1418
PRO A1385
GLY A1386
TRP A1468
 None
 0.97A 2y7kA-2xxzA:
undetectable		 2y7kA-2xxzA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B
(Homo
sapiens) 		3 / 3 CYH A1422
HIS A1425
PHE A1421
 None
 0.96A 3cr4X-2xxzA:
undetectable		 3cr4X-2xxzA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B
(Homo
sapiens) 		4 / 4 GLU A1389
GLY A1464
THR A1465
GLU A1412
 NI  A2494 ( 2.5A)
None
None
None
 1.21A 3e9xA-2xxzA:
undetectable		 3e9xA-2xxzA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B
(Homo
sapiens) 		5 / 12 CYH A1202
LEU A1458
ILE A1185
PHE A1350
MET A1351
 None
None
EDO  A2496 (-3.5A)
None
None
 1.50A 3qt0A-2xxzA:
undetectable		 3qt0A-2xxzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B
(Homo
sapiens) 		5 / 11 LEU A1341
ILE A1400
ILE A1478
VAL A1373
VAL A1482
 None
 0.95A 3w67A-2xxzA:
undetectable		 3w67A-2xxzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B
(Homo
sapiens) 		3 / 3 TRP A1474
ILE A1323
SER A1382
 None
 1.02A 5gqbA-2xxzA:
undetectable		 5gqbA-2xxzA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B
(Homo
sapiens) 		4 / 5 GLY A1426
PRO A1264
TRP A1434
CYH A1265
 None
 1.47A 5nn8A-2xxzA:
0.2		 5nn8A-2xxzA:
17.17