SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 HIS A  60
HIS A 147
HIS A 140
HIS A 211
 None
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
 1.00A 1os2A-2xy4A:
undetectable		 1os2A-2xy4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 6 HIS A  60
HIS A 147
HIS A 140
HIS A 211
 None
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
 1.01A 1y93A-2xy4A:
2.5		 1y93A-2xy4A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		3 / 3 TRP A  80
LEU A  77
LYS A 165
 None
 1.41A 1yajK-2xy4A:
2.6		 1yajK-2xy4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		5 / 12 PHE A 184
TYR A 296
VAL A 195
ALA A 159
ALA A 157
 None
 1.35A 2x2nC-2xy4A:
undetectable		 2x2nC-2xy4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 6 MET A  89
SER A  31
PRO A  83
GLY A  82
 None
 1.35A 2y7pA-2xy4A:
undetectable		 2y7pA-2xy4A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		3 / 3 TYR A 207
GLU A 260
ASP A  55
 None
 0.82A 3bxoB-2xy4A:
undetectable		 3bxoB-2xy4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		5 / 12 GLY A 206
GLY A 204
THR A 224
LEU A 223
PHE A 258
 None
 0.95A 3elwA-2xy4A:
undetectable		 3elwA-2xy4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 HIS A  60
HIS A 147
HIS A 140
HIS A 211
 None
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
 0.91A 3likA-2xy4A:
2.3		 3likA-2xy4A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 HIS A  60
HIS A 147
HIS A 140
HIS A 211
 None
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
 0.90A 3lkaA-2xy4A:
2.2		 3lkaA-2xy4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 8 LEU A  52
VAL A  29
VAL A  78
GLN A 101
 None
 1.01A 4em2A-2xy4A:
0.3		 4em2A-2xy4A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 7 TYR A 296
ILE A  38
ASP A  44
PHE A 184
 None
 0.90A 4iqqA-2xy4A:
undetectable		 4iqqA-2xy4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 8 PRO A 261
ALA A 213
TYR A 214
ASP A 283
 None
ZN  A 401 ( 4.7A)
None
None
 1.01A 4k0bB-2xy4A:
undetectable		 4k0bB-2xy4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 8 PRO A 261
ALA A 213
TYR A 214
ASP A 283
 None
ZN  A 401 ( 4.7A)
None
None
 0.98A 4l7iB-2xy4A:
undetectable		 4l7iB-2xy4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 7 TYR A 296
ILE A 162
ILE A  42
ALA A  41
 None
 0.86A 4lv9A-2xy4A:
undetectable		 4lv9A-2xy4A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 PHE A 263
PRO A 265
VAL A 267
ALA A 259
 None
 1.28A 4w5oA-2xy4A:
5.4		 4w5oA-2xy4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 LEU A 150
ALA A 155
THR A 158
VAL A  81
 None
 0.96A 4xe3A-2xy4A:
undetectable		 4xe3A-2xy4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 PHE A 263
PRO A 265
VAL A 267
ALA A 259
 None
 1.30A 4z4cA-2xy4A:
5.1		 4z4cA-2xy4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 PHE A 263
PRO A 265
VAL A 267
ALA A 259
 None
 1.30A 4z4dA-2xy4A:
undetectable		 4z4dA-2xy4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		5 / 12 LEU A 291
THR A  49
VAL A  28
TYR A  62
SER A  58
 None
 1.24A 5v1tA-2xy4A:
undetectable		 5v1tA-2xy4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 ASP A 192
ILE A 154
ASN A 305
TYR A 221
 None
 1.20A 6a93B-2xy4A:
undetectable		 6a93B-2xy4A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN
(Salmonella
enterica) 		4 / 5 GLU A 260
PRO A 261
THR A 281
GLN A 306
 None
 1.43A 6fgdA-2xy4A:
3.9		 6fgdA-2xy4A:
21.88