SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xy9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ALA A  63
VAL A  58
TRP A  59
 3ES  A1636 ( 3.9A)
None
3ES  A1636 (-3.8A)
 0.87A 1bdwA-2xy9A:
undetectable
1bdwB-2xy9A:
undetectable		 1bdwA-2xy9A:
2.08
1bdwB-2xy9A:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 LEU A 397
PRO A 398
LEU A 401
 None
EPE  A1634 (-3.6A)
None
 0.49A 1hrkA-2xy9A:
undetectable		 1hrkA-2xy9A:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
 3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.25A 1j36A-2xy9A:
51.0		 1j36A-2xy9A:
43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		9 / 12 HIS A 353
GLU A 384
HIS A 383
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
 3ES  A1635 (-3.8A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 1.41A 1j36A-2xy9A:
51.0		 1j36A-2xy9A:
43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
 3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.26A 1j36B-2xy9A:
51.0		 1j36B-2xy9A:
43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		9 / 12 HIS A 353
GLU A 384
HIS A 383
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
 3ES  A1635 (-3.8A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 1.42A 1j36B-2xy9A:
51.0		 1j36B-2xy9A:
43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 11 GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 457
LYS A 511
HIS A 513
TYR A 520
TYR A 523
 3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.1A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.27A 1j37A-2xy9A:
50.9		 1j37A-2xy9A:
43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 11 HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.6A)
 1.08A 1j37A-2xy9A:
50.9		 1j37A-2xy9A:
43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 11 GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 457
LYS A 511
HIS A 513
TYR A 520
TYR A 523
 3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.1A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.27A 1j37B-2xy9A:
50.9		 1j37B-2xy9A:
43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 11 HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.6A)
 1.08A 1j37B-2xy9A:
50.9		 1j37B-2xy9A:
43.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 GLU A 384
GLY A 386
ASP A 377
VAL A 380
GLN A 369
 3ES  A1635 (-2.8A)
None
None
3ES  A1635 (-3.9A)
None
 1.29A 1n2xA-2xy9A:
undetectable		 1n2xA-2xy9A:
17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		12 / 12 GLU A 162
GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 457
LYS A 511
HIS A 513
TYR A 520
TYR A 523
 None
3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.1A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.37A 1o86A-2xy9A:
62.6		 1o86A-2xy9A:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 GLU A 162
HIS A 353
PHE A 460
HIS A 513
TYR A 520
 None
3ES  A1635 (-3.8A)
None
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
 1.39A 1o86A-2xy9A:
62.6		 1o86A-2xy9A:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.6A)
 1.05A 1o86A-2xy9A:
62.6		 1o86A-2xy9A:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 4 SER A 355
VAL A 380
PHE A 512
VAL A 518
 3ES  A1636 (-4.3A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.8A)
3ES  A1636 (-4.1A)
 0.15A 1o86A-2xy9A:
62.6		 1o86A-2xy9A:
99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 LEU A 603
LEU A 247
ASN A 607
LEU A 255
LEU A 266
 None
 1.16A 1og5A-2xy9A:
undetectable		 1og5A-2xy9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ILE A 367
ASP A 358
PHE A 359
 None
 0.61A 1uwjB-2xy9A:
undetectable		 1uwjB-2xy9A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.81A 1v7zA-2xy9A:
undetectable		 1v7zA-2xy9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.83A 1v7zB-2xy9A:
undetectable		 1v7zB-2xy9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.83A 1v7zC-2xy9A:
undetectable		 1v7zC-2xy9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.85A 1v7zD-2xy9A:
undetectable		 1v7zD-2xy9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.85A 1v7zE-2xy9A:
undetectable		 1v7zE-2xy9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.84A 1v7zF-2xy9A:
undetectable		 1v7zF-2xy9A:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 281
HIS A 353
ALA A 354
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
TYR A 520
TYR A 523
 3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
3ES  A1635 (-4.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.33A 2c6nA-2xy9A:
53.0		 2c6nA-2xy9A:
55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		6 / 12 HIS A 353
GLN A 369
LYS A 511
HIS A 513
TYR A 520
TYR A 523
 3ES  A1635 (-3.8A)
None
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 1.25A 2c6nA-2xy9A:
53.0		 2c6nA-2xy9A:
55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		10 / 12 GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
TYR A 520
TYR A 523
 3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.29A 2c6nB-2xy9A:
53.2		 2c6nB-2xy9A:
55.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_ACTB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 4 HIS A 410
PRO A 407
ASN A 406
TYR A 390
 3ES  A1635 (-3.4A)
CL  A1627 ( 4.6A)
None
None
 1.21A 2f7aB-2xy9A:
undetectable		 2f7aB-2xy9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 5 GLY A 190
HIS A 273
ASP A 177
ASP A 187
 None
 1.15A 2oxtB-2xy9A:
undetectable		 2oxtB-2xy9A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 HIS A 383
ASP A 415
SER A 461
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
 1.19A 2p02A-2xy9A:
undetectable		 2p02A-2xy9A:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 11 GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 457
LYS A 511
HIS A 513
TYR A 520
TYR A 523
 3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.1A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.26A 2x8zA-2xy9A:
52.0		 2x8zA-2xy9A:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		8 / 11 HIS A 353
GLU A 384
HIS A 383
GLU A 411
LYS A 511
HIS A 513
TYR A 520
TYR A 523
 3ES  A1635 (-3.8A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 1.46A 2x8zA-2xy9A:
52.0		 2x8zA-2xy9A:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 11 HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.6A)
 1.08A 2x8zA-2xy9A:
52.0		 2x8zA-2xy9A:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
 3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.28A 2x91A-2xy9A:
52.3		 2x91A-2xy9A:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		9 / 12 HIS A 353
GLU A 384
HIS A 383
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
 3ES  A1635 (-3.8A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 1.40A 2x91A-2xy9A:
52.3		 2x91A-2xy9A:
44.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.82A 3a6jA-2xy9A:
undetectable		 3a6jA-2xy9A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.80A 3a6jB-2xy9A:
undetectable		 3a6jB-2xy9A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.80A 3a6jC-2xy9A:
undetectable		 3a6jC-2xy9A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.83A 3a6jE-2xy9A:
undetectable		 3a6jE-2xy9A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.79A 3a6jF-2xy9A:
undetectable		 3a6jF-2xy9A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 HIS A 383
GLU A 384
HIS A 387
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
 0.10A 3kecB-2xy9A:
3.2		 3kecB-2xy9A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 TYR A 523
ASP A 415
ASP A 453
 3ES  A1635 (-3.4A)
3ES  A1635 ( 3.9A)
None
 0.87A 3ou7B-2xy9A:
undetectable		 3ou7B-2xy9A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 GLU A  43
PHE A 102
GLN A  98
 None
 0.74A 3r55A-2xy9A:
1.0		 3r55A-2xy9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 HIS A 513
SER A 526
GLU A 411
 3ES  A1635 (-3.9A)
None
ZN  A1628 ( 2.4A)
 0.88A 3s8pA-2xy9A:
undetectable		 3s8pA-2xy9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 LEU A 452
TRP A 486
ILE A 270
VAL A 251
LEU A 255
 None
CL  A1626 (-4.7A)
None
None
None
 1.13A 3w67B-2xy9A:
undetectable		 3w67B-2xy9A:
17.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 6 HIS A 387
GLU A 411
ASP A 415
SER A 526
 ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 ( 3.9A)
None
 0.27A 4apjA-2xy9A:
57.3
4apjP-2xy9A:
undetectable		 4apjA-2xy9A:
99.83
4apjP-2xy9A:
1.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 11 GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 457
LYS A 511
HIS A 513
TYR A 520
TYR A 523
 3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.1A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
 0.26A 4c2pA-2xy9A:
62.4		 4c2pA-2xy9A:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 11 HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.6A)
 1.08A 4c2pA-2xy9A:
62.4		 4c2pA-2xy9A:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 GLU A 557
LEU A 329
GLY A 559
SER A 555
GLN A 554
 None
 1.30A 4djeA-2xy9A:
undetectable		 4djeA-2xy9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 VAL A 416
LEU A 419
ASN A 406
MET A 592
 None
 0.80A 4e1gB-2xy9A:
undetectable		 4e1gB-2xy9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ARG A 114
LYS A 113
LYS A 117
 None
 1.34A 4k50E-2xy9A:
undetectable		 4k50E-2xy9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 TYR A 520
GLN A 493
TRP A 467
 3ES  A1635 (-4.7A)
None
None
 1.05A 4kn2C-2xy9A:
undetectable		 4kn2C-2xy9A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 6 ASN A 246
GLU A 608
GLU A 606
TYR A 250
 None
 1.33A 4mi4A-2xy9A:
undetectable		 4mi4A-2xy9A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 ASN A 246
GLU A 608
GLU A 606
TYR A 250
 None
 1.30A 4mj8C-2xy9A:
undetectable		 4mj8C-2xy9A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 5 LEU A 463
ASP A 465
TRP A 467
ILE A 514
 None
 1.43A 4mwrA-2xy9A:
undetectable		 4mwrA-2xy9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 HIS A 383
ASP A 415
SER A 461
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
 1.16A 4ndnA-2xy9A:
undetectable		 4ndnA-2xy9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 HIS A 383
ASP A 415
SER A 461
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
 1.23A 4ndnC-2xy9A:
undetectable		 4ndnC-2xy9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 HIS A 383
ASP A 415
SER A 461
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
 1.30A 4odjA-2xy9A:
undetectable		 4odjA-2xy9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 PHE A 570
TYR A 394
GLY A 408
ILE A 529
 None
 0.95A 4qoiA-2xy9A:
undetectable
4qoiB-2xy9A:
undetectable		 4qoiA-2xy9A:
18.84
4qoiB-2xy9A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 HIS A 383
GLU A 384
HIS A 387
GLU A 411
TYR A 523
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-3.4A)
 0.74A 4r7lA-2xy9A:
5.5		 4r7lA-2xy9A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 5 PHE A 322
SER A 355
HIS A 353
ASP A 415
 None
3ES  A1636 (-4.3A)
3ES  A1635 (-3.8A)
3ES  A1635 ( 3.9A)
 1.23A 4rzvB-2xy9A:
undetectable		 4rzvB-2xy9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 SER A 147
TYR A 146
SER A 516
GLU A 143
 None
 0.90A 4xzkA-2xy9A:
undetectable		 4xzkA-2xy9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 HIS A 383
ASP A 415
SER A 461
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
 1.19A 5a1iA-2xy9A:
undetectable		 5a1iA-2xy9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 HIS A 383
ASP A 415
SER A 461
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
 1.19A 5a1iA-2xy9A:
undetectable		 5a1iA-2xy9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 TYR A 523
SER A 526
GLU A 411
PHE A 457
 3ES  A1635 (-3.4A)
None
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.1A)
 0.97A 5aclA-2xy9A:
undetectable		 5aclA-2xy9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 GLY A 494
TYR A 492
LEU A 488
GLY A 615
PHE A 237
 None
 1.01A 5d4uA-2xy9A:
undetectable		 5d4uA-2xy9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 GLY A 494
TYR A 492
LEU A 488
GLY A 615
PHE A 237
 None
 1.05A 5d4uB-2xy9A:
undetectable		 5d4uB-2xy9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 4 ALA A 272
PRO A 459
LEU A 245
HIS A 248
 None
 1.20A 5eskA-2xy9A:
undetectable		 5eskA-2xy9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 HIS A 353
SER A 355
LYS A 368
 3ES  A1635 (-3.8A)
3ES  A1636 (-4.3A)
None
 1.02A 5os7A-2xy9A:
undetectable		 5os7A-2xy9A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 10 VAL A 251
ALA A 254
LEU A 247
LEU A 603
LEU A 452
 None
 0.95A 6f5uA-2xy9A:
undetectable
6f5uB-2xy9A:
undetectable		 6f5uA-2xy9A:
9.21
6f5uB-2xy9A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 HIS A 383
ASP A 415
SER A 461
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
 1.18A 6fboA-2xy9A:
undetectable		 6fboA-2xy9A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 HIS A 383
ASP A 415
SER A 461
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
 1.19A 6fcdA-2xy9A:
undetectable		 6fcdA-2xy9A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 HIS A 383
ASP A 415
SER A 461
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
 1.18A 6g6rA-2xy9A:
undetectable		 6g6rA-2xy9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 HIS A 353
SER A 355
LYS A 368
 3ES  A1635 (-3.8A)
3ES  A1636 (-4.3A)
None
 1.02A 6gmdB-2xy9A:
undetectable		 6gmdB-2xy9A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ARG A 186
LYS A 511
TYR A 146
 CL  A1626 (-3.8A)
3ES  A1635 (-2.6A)
None
 1.36A 6gnaA-2xy9A:
undetectable		 6gnaA-2xy9A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ARG A 186
LYS A 511
TYR A 146
 CL  A1626 (-3.8A)
3ES  A1635 (-2.6A)
None
 1.36A 6gnbA-2xy9A:
undetectable		 6gnbA-2xy9A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLY A 327
LEU A 326
ALA A 558
GLU A 557
 None
 0.73A 6mdqA-2xy9A:
undetectable		 6mdqA-2xy9A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ARG A 604
LEU A 600
PHE A 596
 None
 0.74A 6nknP-2xy9A:
2.1		 6nknP-2xy9A:
19.18