SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xyc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		4 / 7 GLY A 471
ASP A 437
TYR A 473
ARG A 435
 PO4  A1505 (-3.4A)
NAG  A1502 (-3.2A)
PO4  A1506 (-4.7A)
NAG  A1502 (-3.7A)
 1.26A 3arrA-2xycA:
7.5		 3arrA-2xycA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		4 / 7 ASN A 315
TYR A 313
ARG A 353
HIS A 366
 None
 1.22A 3frqB-2xycA:
undetectable		 3frqB-2xycA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		4 / 5 ASP A 520
SER A 521
SER A 412
VAL A 525
 None
 1.06A 3rxhA-2xycA:
undetectable		 3rxhA-2xycA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		4 / 5 SER A 515
PRO A 499
TYR A 500
VAL A 569
 None
 1.23A 3sufC-2xycA:
undetectable		 3sufC-2xycA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		5 / 6 PHE A 586
ALA A 512
PRO A 561
LEU A 559
THR A 510
 None
 1.40A 4dtzA-2xycA:
undetectable		 4dtzA-2xycA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		3 / 3 SER A 498
ALA A 571
VAL A 572
 None
 0.68A 4o2bC-2xycA:
undetectable		 4o2bC-2xycA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		5 / 12 ASP A 351
VAL A 370
PHE A 343
PHE A 341
LEU A 365
 None
 1.14A 5tudA-2xycA:
undetectable		 5tudA-2xycA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		5 / 12 ASP A 351
VAL A 370
PHE A 343
PHE A 341
LEU A 365
 None
 1.18A 5tudD-2xycA:
undetectable		 5tudD-2xycA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens) 		4 / 7 ASP A 374
ARG A 336
TYR A 378
ASP A 339
 None
 1.22A 6mn5E-2xycA:
undetectable		 6mn5E-2xycA:
11.68