SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 GLN A   9
TYR A  76
ARG A  96
 None
None
PEG  A1624 (-4.1A)
 0.87A 1gtbA-2xydA:
undetectable		 1gtbA-2xydA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 LEU A 375
PRO A 376
LEU A 379
 None
 0.46A 1hrkA-2xydA:
undetectable		 1hrkA-2xydA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 259
HIS A 331
THR A 358
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 (-3.6A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.30A 1j36A-2xydA:
49.7		 1j36A-2xydA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 259
HIS A 331
THR A 358
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 (-3.6A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.30A 1j36B-2xydA:
49.7		 1j36B-2xydA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 11 GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 435
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 ( 4.2A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.33A 1j37A-2xydA:
49.7		 1j37A-2xydA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 11 HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 505
 3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-4.7A)
 1.03A 1j37A-2xydA:
49.7		 1j37A-2xydA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 11 GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 435
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 ( 4.2A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.33A 1j37B-2xydA:
49.7		 1j37B-2xydA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 11 HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 505
 3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-4.7A)
 1.03A 1j37B-2xydA:
49.7		 1j37B-2xydA:
40.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 THR A 358
GLU A 262
ASP A 266
 3ES  A1611 (-3.6A)
3ES  A1611 ( 4.7A)
None
 0.78A 1nt2A-2xydA:
undetectable		 1nt2A-2xydA:
14.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 435
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 ( 4.2A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.26A 1o86A-2xydA:
54.3		 1o86A-2xydA:
53.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 505
 3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-4.7A)
 1.00A 1o86A-2xydA:
54.3		 1o86A-2xydA:
53.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 HIS A 491
GLU A 389
HIS A 361
GLU A 362
HIS A 331
 3ES  A1611 (-3.9A)
ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
3ES  A1611 (-3.8A)
 1.31A 1o86A-2xydA:
54.3		 1o86A-2xydA:
53.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 LEU A 426
ALA A 429
ILE A 433
ILE A 248
LEU A 253
 None
 1.14A 1tw4A-2xydA:
undetectable		 1tw4A-2xydA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 6 LEU A 306
ALA A 538
LEU A 304
SER A 533
 None
 1.18A 1tyrA-2xydA:
undetectable		 1tyrA-2xydA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ILE A 345
ASP A 336
PHE A 337
 None
 0.61A 1uwjB-2xydA:
undetectable		 1uwjB-2xydA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.78A 1v7zA-2xydA:
undetectable		 1v7zA-2xydA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.80A 1v7zB-2xydA:
undetectable		 1v7zB-2xydA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.79A 1v7zC-2xydA:
undetectable		 1v7zC-2xydA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.81A 1v7zD-2xydA:
undetectable		 1v7zD-2xydA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.81A 1v7zE-2xydA:
undetectable		 1v7zE-2xydA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.80A 1v7zF-2xydA:
undetectable		 1v7zF-2xydA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 TRP A 335
ARG A 344
PHE A 337
 PEG  A1622 ( 4.0A)
None
None
 1.44A 1zeaH-2xydA:
undetectable
1zeaL-2xydA:
undetectable		 1zeaH-2xydA:
15.41
1zeaL-2xydA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 TRP A 198
THR A 179
TYR A 175
 None
 1.24A 2a3aA-2xydA:
undetectable		 2a3aA-2xydA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 TRP A 198
THR A 179
TYR A 175
 None
 1.20A 2a3aB-2xydA:
undetectable		 2a3aB-2xydA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 TRP A 198
THR A 179
TYR A 175
 None
 1.23A 2a3bA-2xydA:
undetectable		 2a3bA-2xydA:
23.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 259
HIS A 331
ALA A 332
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 (-4.3A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.34A 2c6nA-2xydA:
56.9		 2c6nA-2xydA:
98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 259
HIS A 331
GLN A 355
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
None
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.49A 2c6nA-2xydA:
56.9		 2c6nA-2xydA:
98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		8 / 12 HIS A 331
ALA A 332
HIS A 365
GLU A 362
GLU A 389
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.8A)
3ES  A1611 (-4.3A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 1.46A 2c6nA-2xydA:
56.9		 2c6nA-2xydA:
98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		6 / 12 HIS A 331
GLN A 347
HIS A 365
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.8A)
None
ZN  A1620 ( 3.2A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 1.37A 2c6nA-2xydA:
56.9		 2c6nA-2xydA:
98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		6 / 12 HIS A 331
GLN A 347
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.8A)
None
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 1.26A 2c6nA-2xydA:
56.9		 2c6nA-2xydA:
98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 12 GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
THR A 496
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-3.4A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.36A 2c6nB-2xydA:
56.3		 2c6nB-2xydA:
98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		8 / 12 HIS A 331
HIS A 365
GLU A 362
GLU A 389
HIS A 491
THR A 496
TYR A 498
TYR A 501
 3ES  A1611 (-3.8A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-3.9A)
3ES  A1611 (-3.4A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 1.46A 2c6nB-2xydA:
56.3		 2c6nB-2xydA:
98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ALA A 332
THR A 358
PHE A 490
 3ES  A1611 (-4.3A)
3ES  A1611 (-3.6A)
3ES  A1611 (-4.7A)
 0.24A 2c6nB-2xydA:
56.3		 2c6nB-2xydA:
98.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_ACTB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 4 HIS A 388
PRO A 385
ASN A 384
TYR A 368
 3ES  A1611 (-3.6A)
CL  A1621 ( 4.5A)
None
None
 1.19A 2f7aB-2xydA:
0.0		 2f7aB-2xydA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 4 LEU A 375
PRO A 376
LEU A 379
ARG A 550
 None
 1.28A 2hrcA-2xydA:
undetectable		 2hrcA-2xydA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 THR A 358
HIS A 361
GLU A 362
HIS A 365
 3ES  A1611 (-3.6A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
 0.23A 2jihB-2xydA:
undetectable		 2jihB-2xydA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ASP A 336
THR A 496
PRO A 497
 None
3ES  A1611 (-3.4A)
CL  A1621 (-4.6A)
 0.69A 2pynB-2xydA:
undetectable		 2pynB-2xydA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 LEU A 375
PRO A 376
LEU A 379
 None
 0.47A 2qd5B-2xydA:
undetectable		 2qd5B-2xydA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 11 GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 435
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 ( 4.2A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.22A 2x8zA-2xydA:
50.6		 2x8zA-2xydA:
40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		7 / 11 HIS A 331
GLU A 362
HIS A 361
GLU A 389
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.8A)
3ES  A1611 (-2.5A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 1.44A 2x8zA-2xydA:
50.6		 2x8zA-2xydA:
40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 11 HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 505
 3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-4.7A)
 1.03A 2x8zA-2xydA:
50.6		 2x8zA-2xydA:
40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		10 / 12 GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.22A 2x91A-2xydA:
50.9		 2x91A-2xydA:
40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		8 / 12 HIS A 331
GLU A 362
HIS A 361
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.8A)
3ES  A1611 (-2.5A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 1.43A 2x91A-2xydA:
50.9		 2x91A-2xydA:
40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 SER A 333
THR A 358
PHE A 435
 3ES  A1611 (-4.4A)
3ES  A1611 (-3.6A)
3ES  A1611 ( 4.2A)
 0.27A 2x91A-2xydA:
50.9		 2x91A-2xydA:
40.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 TRP A  40
THR A  44
SER A 123
SER A 119
PHE A 490
 None
None
None
None
3ES  A1611 (-4.7A)
 1.37A 2y00B-2xydA:
undetectable		 2y00B-2xydA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 TRP A  40
THR A  44
SER A 123
SER A 119
PHE A 490
 None
None
None
None
3ES  A1611 (-4.7A)
 1.38A 2y01B-2xydA:
undetectable		 2y01B-2xydA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 GLN A 371
GLY A 547
ASP A 374
LEU A 375
TYR A 369
 None
 1.21A 2zw9B-2xydA:
undetectable		 2zw9B-2xydA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.77A 3a6jA-2xydA:
undetectable		 3a6jA-2xydA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.75A 3a6jB-2xydA:
undetectable		 3a6jB-2xydA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.76A 3a6jC-2xydA:
undetectable		 3a6jC-2xydA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.78A 3a6jE-2xydA:
undetectable		 3a6jE-2xydA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.75A 3a6jF-2xydA:
undetectable		 3a6jF-2xydA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 5 TYR A 237
ALA A 250
ALA A 154
TYR A 607
 None
 1.11A 3d91A-2xydA:
undetectable		 3d91A-2xydA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 4 LEU A 375
PRO A 376
LEU A 379
ARG A 550
 None
 1.12A 3hcoB-2xydA:
undetectable		 3hcoB-2xydA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 PHE A  20
GLN A  25
ILE A  79
GLY A  16
 None
 0.96A 3hjoA-2xydA:
undetectable		 3hjoA-2xydA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 GLU A  77
PRO A  78
GLY A  93
ARG A  89
ARG A  90
 None
None
PEG  A1624 ( 4.9A)
None
None
 1.49A 3jb2A-2xydA:
undetectable		 3jb2A-2xydA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 HIS A 361
GLU A 362
HIS A 365
 3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
 0.12A 3kecB-2xydA:
3.5		 3kecB-2xydA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 LEU A 570
TYR A 573
TYR A 424
ALA A 396
HIS A 512
 None
 1.24A 3ou7C-2xydA:
undetectable		 3ou7C-2xydA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 7 ILE A 248
LEU A 253
LEU A 430
HIS A 226
VAL A 577
 None
 1.26A 3r9vA-2xydA:
undetectable
3r9vB-2xydA:
undetectable		 3r9vA-2xydA:
19.21
3r9vB-2xydA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 HIS A 491
SER A 504
GLU A 389
 3ES  A1611 (-3.9A)
None
ZN  A1620 ( 2.4A)
 0.88A 3s8pA-2xydA:
undetectable		 3s8pA-2xydA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ASP A 336
THR A 496
PRO A 497
 None
3ES  A1611 (-3.4A)
CL  A1621 (-4.6A)
 0.61A 3tkgD-2xydA:
undetectable		 3tkgD-2xydA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 9 GLY A 547
ALA A 546
ILE A 391
LEU A 556
VAL A 555
 None
 1.00A 3u7sB-2xydA:
undetectable		 3u7sB-2xydA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 PHE A 490
SER A 123
SER A 119
 3ES  A1611 (-4.7A)
None
None
 0.94A 3ufgB-2xydA:
undetectable		 3ufgB-2xydA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 TYR A 531
HIS A 360
LEU A 410
TRP A 288
 None
 1.17A 3uzzB-2xydA:
undetectable		 3uzzB-2xydA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 TYR A 222
MET A 267
LEU A 233
 None
 1.01A 3vw1D-2xydA:
undetectable		 3vw1D-2xydA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 LEU A 375
PRO A 376
LEU A 379
 None
 0.41A 3w1wB-2xydA:
undetectable		 3w1wB-2xydA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 6 HIS A 365
GLU A 389
ASP A 393
SER A 504
 ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-3.4A)
None
 0.38A 4apjA-2xydA:
51.3
4apjP-2xydA:
undetectable		 4apjA-2xydA:
53.76
4apjP-2xydA:
3.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		11 / 11 GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 435
LYS A 489
HIS A 491
TYR A 498
TYR A 501
 3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 ( 4.2A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
 0.41A 4c2pA-2xydA:
54.3		 4c2pA-2xydA:
53.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 11 HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 505
 3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-4.7A)
 1.04A 4c2pA-2xydA:
54.3		 4c2pA-2xydA:
53.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 4 PRO A 173
LEU A 174
ILE A 121
ARG A 120
 None
 1.02A 4f4dA-2xydA:
undetectable		 4f4dA-2xydA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 TYR A 498
GLN A 471
TRP A 445
 3ES  A1611 (-4.7A)
None
None
 1.03A 4kn2C-2xydA:
undetectable		 4kn2C-2xydA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 ASP A  43
ASN A  45
SER A  35
 None
NAG  A1614 (-1.9A)
None
 0.85A 4obwA-2xydA:
undetectable		 4obwA-2xydA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 PRO A 170
LEU A 171
GLN A 117
 None
 0.50A 4pevB-2xydA:
undetectable		 4pevB-2xydA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 HIS A 361
GLU A 362
HIS A 365
GLU A 389
TYR A 501
 3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-3.5A)
 0.66A 4r7lA-2xydA:
5.3		 4r7lA-2xydA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 5 PHE A 300
SER A 333
HIS A 331
ASP A 393
 None
3ES  A1611 (-4.4A)
3ES  A1611 (-3.8A)
3ES  A1611 (-3.4A)
 1.26A 4rzvB-2xydA:
undetectable		 4rzvB-2xydA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 ASN A 494
PRO A 493
TRP A 257
PHE A 438
 None
 1.40A 4v32C-2xydA:
undetectable		 4v32C-2xydA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 6 LEU A 306
ALA A 538
LEU A 304
SER A 533
 None
 1.12A 5a6iA-2xydA:
undetectable		 5a6iA-2xydA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 TYR A 501
SER A 504
GLU A 389
PHE A 435
 3ES  A1611 (-3.5A)
None
ZN  A1620 ( 2.4A)
3ES  A1611 ( 4.2A)
 1.07A 5aclA-2xydA:
undetectable		 5aclA-2xydA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 4 ALA A 250
PRO A 437
LEU A 223
HIS A 226
 None
 1.12A 5eskA-2xydA:
undetectable		 5eskA-2xydA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 ILE A 264
HIS A 226
LEU A 225
ALA A 434
 None
 0.89A 5hrqE-2xydA:
undetectable
5hrqF-2xydA:
undetectable
5hrqJ-2xydA:
undetectable		 5hrqE-2xydA:
3.46
5hrqF-2xydA:
7.17
5hrqJ-2xydA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 6 PHE A 438
ARG A 467
PRO A 437
ILE A 473
 None
 1.39A 5ih0A-2xydA:
undetectable		 5ih0A-2xydA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 HIS A 331
SER A 333
LYS A 346
 3ES  A1611 (-3.8A)
3ES  A1611 (-4.4A)
None
 1.08A 5os7A-2xydA:
undetectable		 5os7A-2xydA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 HIS A 365
TRP A 335
HIS A 491
THR A 496
 ZN  A1620 ( 3.2A)
PEG  A1622 ( 4.0A)
3ES  A1611 (-3.9A)
3ES  A1611 (-3.4A)
 1.45A 5yj1G-2xydA:
undetectable
5yj1Y-2xydA:
0.0		 5yj1G-2xydA:
10.03
5yj1Y-2xydA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 8 HIS A 491
THR A 496
HIS A 365
TRP A 335
 3ES  A1611 (-3.9A)
3ES  A1611 (-3.4A)
ZN  A1620 ( 3.2A)
PEG  A1622 ( 4.0A)
 1.39A 5yj1k-2xydA:
0.0
5yj1t-2xydA:
undetectable		 5yj1k-2xydA:
10.03
5yj1t-2xydA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 7 VAL A  36
PHE A 313
MET A 363
LEU A 370
 None
 1.15A 6aycA-2xydA:
2.0		 6aycA-2xydA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		4 / 6 SER A 333
GLN A 347
GLU A 389
THR A 496
 3ES  A1611 (-4.4A)
None
ZN  A1620 ( 2.4A)
3ES  A1611 (-3.4A)
 1.41A 6djzA-2xydA:
0.8		 6djzA-2xydA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		3 / 3 HIS A 331
SER A 333
LYS A 346
 3ES  A1611 (-3.8A)
3ES  A1611 (-4.4A)
None
 1.08A 6gmdB-2xydA:
undetectable		 6gmdB-2xydA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 TRP A  40
THR A  44
SER A 123
SER A 119
PHE A 490
 None
None
None
None
3ES  A1611 (-4.7A)
 1.39A 6h7jA-2xydA:
undetectable		 6h7jA-2xydA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 TRP A  40
THR A  44
SER A 123
SER A 119
PHE A 490
 None
None
None
None
3ES  A1611 (-4.7A)
 1.38A 6h7jB-2xydA:
2.7		 6h7jB-2xydA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens) 		5 / 12 TRP A  40
THR A  44
SER A 123
SER A 119
PHE A 490
 None
None
None
None
3ES  A1611 (-4.7A)
 1.42A 6h7mA-2xydA:
undetectable		 6h7mA-2xydA:
9.72