SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2xyk 2-ON-2 HEMOGLOBIN
(Agrobacterium
tumefaciens) 		4 / 7 ILE A 105
ARG A  19
THR A  58
LEU A  61
 None
 0.96A 1v54N-2xykA:
undetectable
1v54W-2xykA:
undetectable		 1v54N-2xykA:
12.57
1v54W-2xykA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xyk 2-ON-2 HEMOGLOBIN
(Agrobacterium
tumefaciens) 		4 / 6 ILE A 105
ARG A  19
THR A  58
LEU A  61
 None
 1.02A 2einN-2xykA:
undetectable
2einW-2xykA:
undetectable		 2einN-2xykA:
12.57
2einW-2xykA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xyk 2-ON-2 HEMOGLOBIN
(Agrobacterium
tumefaciens) 		4 / 6 ILE A 105
ARG A  19
THR A  58
LEU A  61
 None
 1.04A 3wg7N-2xykA:
2.4
3wg7W-2xykA:
undetectable		 3wg7N-2xykA:
12.57
3wg7W-2xykA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 2xyk 2-ON-2 HEMOGLOBIN
(Agrobacterium
tumefaciens) 		5 / 11 PHE A  97
LEU A   8
LEU A  61
PHE A  53
ILE A 105
 None
None
None
HEM  A 700 (-4.4A)
None
 0.97A 4dm8A-2xykA:
undetectable		 4dm8A-2xykA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2xyk 2-ON-2 HEMOGLOBIN
(Agrobacterium
tumefaciens) 		6 / 12 TYR A  56
LEU A  57
GLY A  59
ILE A 114
LEU A   8
GLY A  62
 HEM  A 700 (-4.1A)
None
None
None
None
None
 1.38A 5wyqB-2xykA:
undetectable		 5wyqB-2xykA:
22.14