SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EIZ_A_SAMA301_1 (FTSJ)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAH A1293 (-2.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.32A	1eizA-2xyqA: 14.8	1eizA-2xyqA: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EJ0_A_SAMA301_1 (FTSJ)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAH A1293 (-2.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.36A	1ej0A-2xyqA: 14.8	1ej0A-2xyqA: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FPQ_A_SAMA1699_0 (ISOLIQUIRITIGENIN 2'-O-METHYLTRANSFERA SE)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 10	GLY A 71 ASN A 43 ASP A 99 LEU A 100 ASP A 114	SAH A1293 (-3.8A) SAH A1293 (-3.8A) SAH A1293 (-2.7A) SAH A1293 (-4.3A) SAH A1293 (-3.7A)	1.34A	1fpqA-2xyqA: 8.2	1fpqA-2xyqA: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HZE_A_RBFA98_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 9	LEU A 180 LEU A 153 ILE A 128 THR A 191 ILE A 207	None	1.36A	1hzeA-2xyqA: undetectable 1hzeB-2xyqA: undetectable	1hzeA-2xyqA: 14.81 1hzeB-2xyqA: 14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HZE_B_RBFB99_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 9	THR A 191 ILE A 207 LEU A 180 LEU A 153 ILE A 128	None	1.36A	1hzeA-2xyqA: undetectable 1hzeB-2xyqA: undetectable	1hzeA-2xyqA: 14.81 1hzeB-2xyqA: 14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I18_A_RBFA98_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 10	LEU A 180 LEU A 153 ILE A 128 THR A 191 ILE A 207	None	1.40A	1i18A-2xyqA: undetectable 1i18B-2xyqA: undetectable	1i18A-2xyqA: 14.81 1i18B-2xyqA: 14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I18_B_RBFB99_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 10	THR A 191 ILE A 207 LEU A 180 LEU A 153 ILE A 128	None	1.42A	1i18A-2xyqA: undetectable 1i18B-2xyqA: undetectable	1i18A-2xyqA: 14.81 1i18B-2xyqA: 14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IGX_A_EPAA700_1 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	LEU A 54 GLY A 208 ALA A 209 SER A 166 GLY A 164	None None None NA A1295 (-2.7A) None	1.14A	1igxA-2xyqA: undetectable	1igxA-2xyqA: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9Q_B_CHDB500_0 (ESTROGEN-RELATED RECEPTOR GAMMA)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 4	LEU A 206 VAL A 169 ILE A 167 TRP A 190	None	1.08A	1s9qB-2xyqA: undetectable	1s9qB-2xyqA: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B25_A_SAMA601_0 (HYPOTHETICAL PROTEIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 MET A 131	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.6A) SAH A1293 (-3.7A) SAH A1293 (-3.8A)	0.98A	2b25A-2xyqA: 8.6	2b25A-2xyqA: 22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_A_SAMA1001_1 (SAM DEPENDENT METHYLTRANSFERASE)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAH A1293 (-2.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.74A	2igtA-2xyqA: 8.7	2igtA-2xyqA: 23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_B_SAMB1002_1 (SAM DEPENDENT METHYLTRANSFERASE)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAH A1293 (-2.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.75A	2igtB-2xyqA: 8.6	2igtB-2xyqA: 23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_C_SAMC300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 LEU A 100 ASP A 130 LYS A 170	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-4.3A) SAH A1293 (-3.7A) None	0.88A	2oxtC-2xyqA: 10.4	2oxtC-2xyqA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_1 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASP A 99 ASP A 114 ASP A 130	SAH A1293 (-2.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.34A	3douA-2xyqA: 13.1	3douA-2xyqA: 23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_C_MTXC164_2 (DIHYDROFOLATE REDUCTASE)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 4	ILE A 128 ARG A 283 ILE A 127 THR A 82	None	1.15A	3ia4C-2xyqA: undetectable	3ia4C-2xyqA: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LB3_B_4CHB192_0 (DEHALOPEROXIDASE A)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 6	TYR A 152 HIS A 119 THR A 120 VAL A 290	None	1.25A	3lb3B-2xyqA: undetectable	3lb3B-2xyqA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P97_A_SAMA263_0 (NON-STRUCTURAL PROTEIN 5)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.6A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.89A	3p97A-2xyqA: 10.4	3p97A-2xyqA: 19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P97_C_SAMC263_0 (NON-STRUCTURAL PROTEIN 5)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.6A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.87A	3p97C-2xyqA: 10.5	3p97C-2xyqA: 19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3R24_A_SAMA302_0 (2'-O-METHYL TRANSFERASE)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	12 / 12	ASN A 43 GLY A 71 SER A 74 PRO A 80 GLY A 81 LEU A 100 ASN A 101 ASP A 114 CYH A 115 MET A 131 PHE A 149 LYS A 170	SAH A1293 (-3.8A) SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.8A) SAH A1293 (-3.6A) SAH A1293 (-4.3A) SAH A1293 ( 4.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A) SAH A1293 (-3.8A) SAH A1293 (-4.6A) None	0.43A	3r24A-2xyqA: 49.3	3r24A-2xyqA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3R24_A_SAMA302_1 (2'-O-METHYL TRANSFERASE)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	TYR A 47 ASP A 99 ASP A 130	SAH A1293 (-4.8A) SAH A1293 (-2.7A) SAH A1293 (-3.7A)	0.09A	3r24A-2xyqA: 49.3	3r24A-2xyqA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B17_A_SAMA1358_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 81 ASP A 99 ASP A 130 MET A 131	SAH A1293 (-3.8A) SAH A1293 (-3.6A) SAH A1293 (-2.7A) SAH A1293 (-3.7A) SAH A1293 (-3.8A)	0.88A	4b17A-2xyqA: 9.8	4b17A-2xyqA: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B17_A_SAMA1358_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 81 ASP A 99 ASP A 114 ASP A 130 MET A 131	SAH A1293 (-3.6A) SAH A1293 (-2.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A) SAH A1293 (-3.8A)	1.00A	4b17A-2xyqA: 9.8	4b17A-2xyqA: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G77_A_TLFA711_0 (LACTOTRANSFERRIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 7	ILE A 128 LEU A 126 ALA A 168 TYR A 47	None None None SAH A1293 (-4.8A)	0.75A	4g77A-2xyqA: undetectable	4g77A-2xyqA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XYZ_A_ACTA103_0 (POLYUBIQUITIN-C)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	4 / 4	LEU A 95 ILE A 128 HIS A 69 VAL A 67	None	1.17A	4xyzA-2xyqA: undetectable	4xyzA-2xyqA: 16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E9Q_C_SAMC4000_0 (GENOME POLYPROTEIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.6A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.85A	5e9qC-2xyqA: 9.6	5e9qC-2xyqA: 19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EC8_C_SAMC4000_0 (GENOME POLYPROTEIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.6A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.89A	5ec8C-2xyqA: 10.0	5ec8C-2xyqA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIF_A_SAMA301_0 (GENOME POLYPROTEIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.6A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.89A	5eifA-2xyqA: 10.0	5eifA-2xyqA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIF_C_SAMC4000_0 (GENOME POLYPROTEIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.6A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.86A	5eifC-2xyqA: 8.1	5eifC-2xyqA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IH0_A_ERYA404_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	ILE A 157 GLY A 208 PHE A 70 SER A 175 ILE A 171	None	1.08A	5ih0A-2xyqA: undetectable	5ih0A-2xyqA: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KQS_A_SAMA307_0 (GENOME POLYPROTEIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.6A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.88A	5kqsA-2xyqA: 10.5	5kqsA-2xyqA: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NJV_A_SAMA301_0 (NS5)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 71 GLY A 73 GLY A 81 ASP A 114 ASP A 130	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-3.6A) SAH A1293 (-3.7A) SAH A1293 (-3.7A)	0.89A	5njvA-2xyqA: 10.6	5njvA-2xyqA: 20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5YN6_A_SAMA401_0 (NSP16 PROTEIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	11 / 12	TYR A 47 GLY A 71 PRO A 80 GLY A 81 LEU A 100 ASN A 101 ASP A 114 CYH A 115 ASP A 130 MET A 131 PHE A 149	SAH A1293 (-4.8A) SAH A1293 (-3.8A) SAH A1293 (-3.8A) SAH A1293 (-3.6A) SAH A1293 (-4.3A) SAH A1293 ( 4.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A) SAH A1293 (-3.8A) SAH A1293 (-4.6A)	0.37A	5yn6A-2xyqA: 45.7	5yn6A-2xyqA: 64.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5YNI_A_SAMA401_0 (NSP16 PROTEIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	11 / 12	TYR A 47 GLY A 71 PRO A 80 GLY A 81 ASP A 99 LEU A 100 ASN A 101 ASP A 114 CYH A 115 ASP A 130 MET A 131	SAH A1293 (-4.8A) SAH A1293 (-3.8A) SAH A1293 (-3.8A) SAH A1293 (-3.6A) SAH A1293 (-2.7A) SAH A1293 (-4.3A) SAH A1293 ( 4.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A) SAH A1293 (-3.8A)	0.35A	5yniA-2xyqA: 45.5	5yniA-2xyqA: 64.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5YNM_A_SAMA401_0 (NSP16 PROTEIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	11 / 12	TYR A 47 GLY A 71 PRO A 80 GLY A 81 ASP A 99 LEU A 100 ASN A 101 ASP A 114 CYH A 115 ASP A 130 MET A 131	SAH A1293 (-4.8A) SAH A1293 (-3.8A) SAH A1293 (-3.8A) SAH A1293 (-3.6A) SAH A1293 (-2.7A) SAH A1293 (-4.3A) SAH A1293 ( 4.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A) SAH A1293 (-3.7A) SAH A1293 (-3.8A)	0.35A	5ynmA-2xyqA: 45.5	5ynmA-2xyqA: 64.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DM0_B_CYZB1302_0 (GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 10	LEU A 161 LEU A 275 ILE A 167 SER A 188 GLY A 208	None None None MG A1296 ( 4.6A) None	1.27A	6dm0B-2xyqA: undetectable 6dm0C-2xyqA: 4.2	6dm0B-2xyqA: 13.45 6dm0C-2xyqA: 13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6I5Z_D_SAMD401_0 (O-METHYLTRANSFERASE 1)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 11	GLY A 71 GLY A 73 ASP A 99 LEU A 100 ASP A 114	SAH A1293 (-3.8A) SAH A1293 (-4.1A) SAH A1293 (-2.7A) SAH A1293 (-4.3A) SAH A1293 (-3.7A)	0.84A	6i5zD-2xyqA: 6.2	6i5zD-2xyqA: 25.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EIZ_A_SAMA301_1","FTSJ","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAH A1293 (-2.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.32A","1eizA-2xyqA:14.8","1eizA-2xyqA:22.30"],["1EJ0_A_SAMA301_1","FTSJ","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAH A1293 (-2.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.36A","1ej0A-2xyqA:14.8","1ej0A-2xyqA:22.30"],["1FPQ_A_SAMA1699_0","ISOLIQUIRITIGENIN 2'-O-METHYLTRANSFERASE","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;ASN A  43;ASP A  99;LEU A 100;ASP A 114","SAH A1293 (-3.8A);SAH A1293 (-3.8A);SAH A1293 (-2.7A);SAH A1293 (-4.3A);SAH A1293 (-3.7A)","1.34A","1fpqA-2xyqA:8.2","1fpqA-2xyqA:22.93"],["1HZE_A_RBFA98_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"LEU A 180;LEU A 153;ILE A 128;THR A 191;ILE A 207","None","1.36A","1hzeA-2xyqA:undetectable;1hzeB-2xyqA:undetectable","1hzeA-2xyqA:14.81;1hzeB-2xyqA:14.81"],["1HZE_B_RBFB99_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"THR A 191;ILE A 207;LEU A 180;LEU A 153;ILE A 128","None","1.36A","1hzeA-2xyqA:undetectable;1hzeB-2xyqA:undetectable","1hzeA-2xyqA:14.81;1hzeB-2xyqA:14.81"],["1I18_A_RBFA98_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"LEU A 180;LEU A 153;ILE A 128;THR A 191;ILE A 207","None","1.40A","1i18A-2xyqA:undetectable;1i18B-2xyqA:undetectable","1i18A-2xyqA:14.81;1i18B-2xyqA:14.81"],["1I18_B_RBFB99_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"THR A 191;ILE A 207;LEU A 180;LEU A 153;ILE A 128","None","1.42A","1i18A-2xyqA:undetectable;1i18B-2xyqA:undetectable","1i18A-2xyqA:14.81;1i18B-2xyqA:14.81"],["1IGX_A_EPAA700_1","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"LEU A  54;GLY A 208;ALA A 209;SER A 166;GLY A 164","None;None;None; NA A1295 (-2.7A);None","1.14A","1igxA-2xyqA:undetectable","1igxA-2xyqA:17.93"],["1S9Q_B_CHDB500_0","ESTROGEN-RELATED RECEPTOR GAMMA","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"LEU A 206;VAL A 169;ILE A 167;TRP A 190","None","1.08A","1s9qB-2xyqA:undetectable","1s9qB-2xyqA:22.04"],["2B25_A_SAMA601_0","HYPOTHETICAL PROTEIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;MET A 131","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.6A);SAH A1293 (-3.7A);SAH A1293 (-3.8A)","0.98A","2b25A-2xyqA:8.6","2b25A-2xyqA:22.95"],["2IGT_A_SAMA1001_1","SAM DEPENDENT METHYLTRANSFERASE","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAH A1293 (-2.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.74A","2igtA-2xyqA:8.7","2igtA-2xyqA:23.16"],["2IGT_B_SAMB1002_1","SAM DEPENDENT METHYLTRANSFERASE","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAH A1293 (-2.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.75A","2igtB-2xyqA:8.6","2igtB-2xyqA:23.16"],["2OXT_C_SAMC300_0","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;LEU A 100;ASP A 130;LYS A 170","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-4.3A);SAH A1293 (-3.7A);None","0.88A","2oxtC-2xyqA:10.4","2oxtC-2xyqA:21.67"],["3DOU_A_SAMA1_1","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"ASP A  99;ASP A 114;ASP A 130","SAH A1293 (-2.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.34A","3douA-2xyqA:13.1","3douA-2xyqA:23.00"],["3IA4_C_MTXC164_2","DIHYDROFOLATE REDUCTASE","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"ILE A 128;ARG A 283;ILE A 127;THR A  82","None","1.15A","3ia4C-2xyqA:undetectable","3ia4C-2xyqA:22.03"],["3LB3_B_4CHB192_0","DEHALOPEROXIDASE A","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"TYR A 152;HIS A 119;THR A 120;VAL A 290","None","1.25A","3lb3B-2xyqA:undetectable","3lb3B-2xyqA:18.82"],["3P97_A_SAMA263_0","NON-STRUCTURAL PROTEIN 5","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.6A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.89A","3p97A-2xyqA:10.4","3p97A-2xyqA:19.68"],["3P97_C_SAMC263_0","NON-STRUCTURAL PROTEIN 5","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.6A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.87A","3p97C-2xyqA:10.5","3p97C-2xyqA:19.68"],["3R24_A_SAMA302_0","2'-O-METHYL TRANSFERASE","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",12,"ASN A  43;GLY A  71;SER A  74;PRO A  80;GLY A  81;LEU A 100;ASN A 101;ASP A 114;CYH A 115;MET A 131;PHE A 149;LYS A 170","SAH A1293 (-3.8A);SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.8A);SAH A1293 (-3.6A);SAH A1293 (-4.3A);SAH A1293 ( 4.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A);SAH A1293 (-3.8A);SAH A1293 (-4.6A);None","0.43A","3r24A-2xyqA:49.3","3r24A-2xyqA:100.00"],["3R24_A_SAMA302_1","2'-O-METHYL TRANSFERASE","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"TYR A  47;ASP A  99;ASP A 130","SAH A1293 (-4.8A);SAH A1293 (-2.7A);SAH A1293 (-3.7A)","0.09A","3r24A-2xyqA:49.3","3r24A-2xyqA:100.00"],["4B17_A_SAMA1358_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  81;ASP A  99;ASP A 130;MET A 131","SAH A1293 (-3.8A);SAH A1293 (-3.6A);SAH A1293 (-2.7A);SAH A1293 (-3.7A);SAH A1293 (-3.8A)","0.88A","4b17A-2xyqA:9.8","4b17A-2xyqA:20.47"],["4B17_A_SAMA1358_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  81;ASP A  99;ASP A 114;ASP A 130;MET A 131","SAH A1293 (-3.6A);SAH A1293 (-2.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A);SAH A1293 (-3.8A)","1.00A","4b17A-2xyqA:9.8","4b17A-2xyqA:20.47"],["4G77_A_TLFA711_0","LACTOTRANSFERRIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"ILE A 128;LEU A 126;ALA A 168;TYR A  47","None;None;None;SAH A1293 (-4.8A)","0.75A","4g77A-2xyqA:undetectable","4g77A-2xyqA:21.04"],["4XYZ_A_ACTA103_0","POLYUBIQUITIN-C","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",4,"LEU A  95;ILE A 128;HIS A  69;VAL A  67","None","1.17A","4xyzA-2xyqA:undetectable","4xyzA-2xyqA:16.79"],["5E9Q_C_SAMC4000_0","GENOME POLYPROTEIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.6A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.85A","5e9qC-2xyqA:9.6","5e9qC-2xyqA:19.81"],["5EC8_C_SAMC4000_0","GENOME POLYPROTEIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.6A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.89A","5ec8C-2xyqA:10.0","5ec8C-2xyqA:20.38"],["5EIF_A_SAMA301_0","GENOME POLYPROTEIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.6A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.89A","5eifA-2xyqA:10.0","5eifA-2xyqA:20.38"],["5EIF_C_SAMC4000_0","GENOME POLYPROTEIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.6A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.86A","5eifC-2xyqA:8.1","5eifC-2xyqA:20.38"],["5IH0_A_ERYA404_0","MACROLIDE 2'-PHOSPHOTRANSFERASE II","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"ILE A 157;GLY A 208;PHE A  70;SER A 175;ILE A 171","None","1.08A","5ih0A-2xyqA:undetectable","5ih0A-2xyqA:22.09"],["5KQS_A_SAMA307_0","GENOME POLYPROTEIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.6A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.88A","5kqsA-2xyqA:10.5","5kqsA-2xyqA:20.25"],["5NJV_A_SAMA301_0","NS5","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;GLY A  81;ASP A 114;ASP A 130","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-3.6A);SAH A1293 (-3.7A);SAH A1293 (-3.7A)","0.89A","5njvA-2xyqA:10.6","5njvA-2xyqA:20.82"],["5YN6_A_SAMA401_0","NSP16 PROTEIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",11,"TYR A  47;GLY A  71;PRO A  80;GLY A  81;LEU A 100;ASN A 101;ASP A 114;CYH A 115;ASP A 130;MET A 131;PHE A 149","SAH A1293 (-4.8A);SAH A1293 (-3.8A);SAH A1293 (-3.8A);SAH A1293 (-3.6A);SAH A1293 (-4.3A);SAH A1293 ( 4.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A);SAH A1293 (-3.8A);SAH A1293 (-4.6A)","0.37A","5yn6A-2xyqA:45.7","5yn6A-2xyqA:64.19"],["5YNI_A_SAMA401_0","NSP16 PROTEIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",11,"TYR A  47;GLY A  71;PRO A  80;GLY A  81;ASP A  99;LEU A 100;ASN A 101;ASP A 114;CYH A 115;ASP A 130;MET A 131","SAH A1293 (-4.8A);SAH A1293 (-3.8A);SAH A1293 (-3.8A);SAH A1293 (-3.6A);SAH A1293 (-2.7A);SAH A1293 (-4.3A);SAH A1293 ( 4.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A);SAH A1293 (-3.8A)","0.35A","5yniA-2xyqA:45.5","5yniA-2xyqA:64.19"],["5YNM_A_SAMA401_0","NSP16 PROTEIN","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",11,"TYR A  47;GLY A  71;PRO A  80;GLY A  81;ASP A  99;LEU A 100;ASN A 101;ASP A 114;CYH A 115;ASP A 130;MET A 131","SAH A1293 (-4.8A);SAH A1293 (-3.8A);SAH A1293 (-3.8A);SAH A1293 (-3.6A);SAH A1293 (-2.7A);SAH A1293 (-4.3A);SAH A1293 ( 4.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A);SAH A1293 (-3.7A);SAH A1293 (-3.8A)","0.35A","5ynmA-2xyqA:45.5","5ynmA-2xyqA:64.19"],["6DM0_B_CYZB1302_0","GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"LEU A 161;LEU A 275;ILE A 167;SER A 188;GLY A 208","None;None;None; MG A1296 ( 4.6A);None","1.27A","6dm0B-2xyqA:undetectable;6dm0C-2xyqA:4.2","6dm0B-2xyqA:13.45;6dm0C-2xyqA:13.45"],["6I5Z_D_SAMD401_0","O-METHYLTRANSFERASE 1","2xyq","PUTATIVE 2'-O-METHYL TRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  71;GLY A  73;ASP A  99;LEU A 100;ASP A 114","SAH A1293 (-3.8A);SAH A1293 (-4.1A);SAH A1293 (-2.7A);SAH A1293 (-4.3A);SAH A1293 (-3.7A)","0.84A","6i5zD-2xyqA:6.2","6i5zD-2xyqA:25.00"]]