SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xz3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 10 GLU A 156
GLU A 157
LEU A 161
MET A 250
LEU A 141
None
1.50A 1a29A-2xz3A:
undetectable
1a29A-2xz3A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
4 / 6 VAL A  34
VAL A  76
ILE A  86
ASN A 293
None
None
None
EDO  A1494 ( 4.1A)
0.91A 1e06A-2xz3A:
undetectable
1e06A-2xz3A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
4 / 5 LEU A 288
GLY A 315
ALA A 135
ILE A 134
None
EDO  A1491 ( 3.7A)
None
None
0.81A 2aohB-2xz3A:
undetectable
2aohB-2xz3A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 11 THR A 119
GLN A 351
ALA A 350
ALA A 329
ALA A 327
None
1.13A 2f16H-2xz3A:
undetectable
2f16I-2xz3A:
undetectable
2f16H-2xz3A:
18.81
2f16I-2xz3A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 11 THR A 119
GLN A 351
ALA A 350
ALA A 329
ALA A 327
None
1.12A 2f16V-2xz3A:
undetectable
2f16W-2xz3A:
undetectable
2f16V-2xz3A:
18.81
2f16W-2xz3A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 ALA A 290
LEU A 306
PHE A 305
VAL A 319
GLY A  42
None
1.10A 2ve3A-2xz3A:
undetectable
2ve3A-2xz3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
4 / 8 THR A 119
LEU A 311
ASP A 313
GLU A 137
None
None
None
MAL  A1488 (-2.9A)
1.06A 2zw9A-2xz3A:
undetectable
2zw9A-2xz3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 LEU A 218
THR A 219
ALA A 372
THR A 371
ILE A 374
None
1.18A 3a35A-2xz3A:
undetectable
3a35A-2xz3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 LEU A 218
THR A 219
ALA A 372
THR A 371
ILE A 374
None
1.19A 3a35B-2xz3A:
undetectable
3a35B-2xz3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 LEU A 218
THR A 219
ALA A 372
THR A 371
ILE A 374
None
1.22A 3a3bA-2xz3A:
undetectable
3a3bA-2xz3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
4 / 6 PHE A 284
ALA A 188
LEU A 273
PRO A 185
EDO  A1490 (-3.7A)
EDO  A1490 ( 3.7A)
None
None
0.93A 3bgdA-2xz3A:
undetectable
3bgdA-2xz3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
4 / 7 VAL A 136
GLY A 326
PRO A 255
LYS A 331
None
0.76A 3bjwC-2xz3A:
undetectable
3bjwC-2xz3A:
13.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
9 / 12 ASP A  40
LYS A  41
GLU A  70
GLU A  71
ALA A  89
ASP A  91
ARG A  92
GLU A 137
TRP A 256
MAL  A1488 (-3.0A)
MAL  A1488 (-2.5A)
None
None
MAL  A1488 (-3.2A)
MAL  A1488 (-2.8A)
MAL  A1488 (-3.8A)
MAL  A1488 (-2.9A)
MAL  A1488 (-4.5A)
0.81A 3jyrA-2xz3A:
62.4
3jyrA-2xz3A:
83.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
9 / 12 ASP A  40
LYS A  41
GLU A  70
GLU A  71
ALA A  89
ASP A  91
GLU A 137
PRO A 180
TRP A 256
MAL  A1488 (-3.0A)
MAL  A1488 (-2.5A)
None
None
MAL  A1488 (-3.2A)
MAL  A1488 (-2.8A)
MAL  A1488 (-2.9A)
MAL  A1488 (-3.4A)
MAL  A1488 (-4.5A)
0.56A 3jyrA-2xz3A:
62.4
3jyrA-2xz3A:
83.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
6 / 7 ASN A  38
TRP A  88
GLU A 179
TYR A 181
MET A 356
TRP A 366
MAL  A1488 (-4.6A)
MAL  A1488 (-4.5A)
MAL  A1488 (-3.6A)
MAL  A1488 (-3.8A)
MAL  A1488 (-4.4A)
MAL  A1488 (-3.8A)
0.16A 3jyrA-2xz3A:
62.4
3jyrA-2xz3A:
83.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 12 ALA A 188
LEU A 186
ILE A 374
ARG A 370
LEU A 177
EDO  A1490 ( 3.7A)
None
None
MAL  A1488 (-4.3A)
None
0.99A 3mb5A-2xz3A:
undetectable
3mb5A-2xz3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 11 THR A 119
GLN A 351
ALA A 350
ALA A 329
ALA A 327
None
1.17A 3mg0V-2xz3A:
undetectable
3mg0W-2xz3A:
undetectable
3mg0V-2xz3A:
18.81
3mg0W-2xz3A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 VAL A 222
LEU A 186
GLY A 213
ALA A 214
LEU A 387
None
1.02A 3n8yB-2xz3A:
undetectable
3n8yB-2xz3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 9 ILE A 158
LEU A 224
LYS A 282
ILE A 252
GLY A 217
None
1.23A 3sj4X-2xz3A:
undetectable
3sj4X-2xz3A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 PHE A 182
GLY A 326
LEU A 325
GLU A 137
ALA A 257
None
None
None
MAL  A1488 (-2.9A)
None
0.87A 3tbgB-2xz3A:
undetectable
3tbgB-2xz3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 PHE A 182
GLY A 326
LEU A 325
GLU A 137
ALA A 257
None
None
None
MAL  A1488 (-2.9A)
None
0.85A 3tbgD-2xz3A:
undetectable
3tbgD-2xz3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 ALA A 257
TYR A  43
TYR A 236
ASN A 260
GLY A 254
None
1.36A 3vwqA-2xz3A:
undetectable
3vwqA-2xz3A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 11 ALA A 257
ASP A 322
TYR A 236
ASN A 260
GLY A 254
None
1.29A 3vwrA-2xz3A:
0.0
3vwrA-2xz3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
4 / 5 GLU A 334
ASP A 340
ASP A 313
ASN A 320
None
1.35A 3vywD-2xz3A:
undetectable
3vywD-2xz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
4 / 5 ASN A 293
ALA A  77
GLY A  82
ASP A  40
EDO  A1494 ( 4.1A)
None
EDO  A1494 (-4.4A)
MAL  A1488 (-3.0A)
0.95A 4n48A-2xz3A:
undetectable
4n48A-2xz3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 9 ALA A 290
ALA A 131
LEU A 129
LEU A 288
VAL A 287
None
1.16A 4or0B-2xz3A:
undetectable
4or0B-2xz3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
3 / 3 ASP A 442
ARG A 438
TYR A 445
None
EDO  A1493 (-3.8A)
None
0.94A 5a7mA-2xz3A:
undetectable
5a7mA-2xz3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
3 / 3 ASP A 442
ARG A 438
TYR A 445
None
EDO  A1493 (-3.8A)
None
0.93A 5a7mB-2xz3A:
undetectable
5a7mB-2xz3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 GLN A  75
ALA A 295
GLY A  80
THR A  79
ALA A  78
None
EDO  A1494 ( 4.4A)
None
None
None
1.20A 5l66H-2xz3A:
undetectable
5l66I-2xz3A:
undetectable
5l66H-2xz3A:
22.28
5l66I-2xz3A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
5 / 12 GLN A  75
ALA A 295
GLY A  80
THR A  79
ALA A  78
None
EDO  A1494 ( 4.4A)
None
None
None
1.20A 5l66V-2xz3A:
undetectable
5l66W-2xz3A:
undetectable
5l66V-2xz3A:
22.28
5l66W-2xz3A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
6 / 12 ALA A 368
ALA A 364
GLY A 192
ALA A 214
PHE A 195
VAL A 207
None
1.42A 5w4zA-2xz3A:
undetectable
5w4zA-2xz3A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
6 / 12 ALA A 368
ALA A 364
GLY A 192
ALA A 214
PHE A 195
VAL A 207
None
1.45A 5w4zB-2xz3A:
undetectable
5w4zB-2xz3A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 12 GLY A 286
LYS A 323
ASP A 322
VAL A 319
ILE A  37
None
0.99A 5wz1A-2xz3A:
undetectable
5wz1A-2xz3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 12 GLY A 286
LYS A 323
ASP A 322
VAL A 319
ILE A  37
None
1.02A 5wz1C-2xz3A:
undetectable
5wz1C-2xz3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 12 GLY A 286
LYS A 323
ASP A 322
VAL A 319
ILE A  37
None
1.04A 5wz1D-2xz3A:
undetectable
5wz1D-2xz3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 12 GLY A 286
LYS A 323
ASP A 322
VAL A 319
ILE A  37
None
1.03A 5wz1E-2xz3A:
undetectable
5wz1E-2xz3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 12 GLY A 286
LYS A 323
ASP A 322
VAL A 319
ILE A  37
None
1.04A 5wz1F-2xz3A:
undetectable
5wz1F-2xz3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 12 GLY A 286
LYS A 323
ASP A 322
VAL A 319
ILE A  37
None
1.00A 5wz1G-2xz3A:
undetectable
5wz1G-2xz3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 12 GLY A 286
LYS A 323
ASP A 322
VAL A 319
ILE A  37
None
1.01A 5wz1H-2xz3A:
undetectable
5wz1H-2xz3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
3 / 3 TYR A 181
ASN A 253
LEU A 139
MAL  A1488 (-3.8A)
None
None
0.83A 6b58A-2xz3A:
2.0
6b58A-2xz3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 11 PRO A 159
GLU A 156
PRO A 280
ALA A 189
PRO A 185
None
1.44A 6bm5A-2xz3A:
undetectable
6bm5A-2xz3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine
leukemia
virus;
Escherichia
coli)
4 / 7 ASP A 384
ALA A 388
LYS A 215
LEU A 218
None
0.98A 6ci6A-2xz3A:
undetectable
6ci6A-2xz3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine
leukemia
virus)
5 / 12 LEU A 301
GLY A  50
VAL A  61
LEU A  33
ILE A  35
None
1.02A 6ecxA-2xz3A:
undetectable
6ecxA-2xz3A:
22.02