SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF
(Drosophila
melanogaster) 		5 / 12 LEU A 328
LEU A 362
TRP A 315
ALA A 343
LEU A 344
 None
 1.04A 2aylB-2xz8A:
undetectable		 2aylB-2xz8A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF
(Drosophila
melanogaster) 		4 / 6 PHE A 272
GLN A 274
ASN A 308
ASN A 286
 None
 1.27A 2nyrA-2xz8A:
undetectable		 2nyrA-2xz8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF
(Drosophila
melanogaster) 		5 / 12 PHE A 332
GLY A 305
ILE A 309
ASN A 308
PHE A 263
 None
 1.23A 2zzmA-2xz8A:
undetectable		 2zzmA-2xz8A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF
(Drosophila
melanogaster) 		5 / 9 ALA A 312
ILE A 289
THR A 266
ILE A 333
VAL A 302
 None
 1.08A 4nptA-2xz8A:
undetectable		 4nptA-2xz8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF
(Drosophila
melanogaster) 		3 / 3 ASP A 306
LYS A 234
LEU A 346
 None
 1.07A 4ptjA-2xz8A:
undetectable		 4ptjA-2xz8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF
(Drosophila
melanogaster) 		5 / 12 TYR A 299
LEU A 284
THR A 268
ILE A 333
GLY A 334
 None
 1.16A 5ifuA-2xz8A:
undetectable		 5ifuA-2xz8A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF
(Drosophila
melanogaster) 		5 / 9 TYR A 299
LEU A 284
THR A 268
ILE A 333
GLY A 334
 None
 1.15A 5ifuB-2xz8A:
undetectable		 5ifuB-2xz8A:
15.22