SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2xzd DARPIN-3.4
(synthetic
construct) 		5 / 9 ASN G 123
THR G  89
ALA G  88
LEU G  86
ALA G 116
 None
 1.48A 3kp6B-2xzdG:
undetectable		 3kp6B-2xzdG:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2xzd DARPIN-3.4
(synthetic
construct) 		5 / 12 ILE G  95
THR G  22
LEU G  67
LEU G  66
THR G  49
 None
 1.01A 4c9lA-2xzdG:
undetectable		 4c9lA-2xzdG:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2xzd DARPIN-3.4
(synthetic
construct) 		5 / 12 ILE G  95
THR G  22
LEU G  67
LEU G  66
THR G  49
 None
 1.01A 4c9lB-2xzdG:
undetectable		 4c9lB-2xzdG:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2xzd DARPIN-3.4
(synthetic
construct) 		4 / 8 THR G  22
LEU G  67
LEU G  66
THR G  49
 None
 0.78A 4c9nA-2xzdG:
undetectable		 4c9nA-2xzdG:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2xzd DARPIN-3.4
(synthetic
construct) 		5 / 12 ILE G  95
THR G  22
LEU G  67
LEU G  66
THR G  49
 None
 1.06A 4c9oA-2xzdG:
undetectable		 4c9oA-2xzdG:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2xzd DARPIN-3.4
(synthetic
construct) 		5 / 11 ILE G  62
LEU G  51
HIS G  69
LEU G  67
ALA G  71
 None
 1.00A 4p65E-2xzdG:
undetectable
4p65F-2xzdG:
undetectable
4p65J-2xzdG:
undetectable
4p65L-2xzdG:
undetectable		 4p65E-2xzdG:
7.46
4p65F-2xzdG:
14.53
4p65J-2xzdG:
14.53
4p65L-2xzdG:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 2xzd DARPIN-3.4
(synthetic
construct) 		5 / 12 VAL G  30
LEU G  18
LEU G  51
ILE G  62
ALA G  71
 None
 0.96A 4p65B-2xzdG:
undetectable
4p65D-2xzdG:
undetectable
4p65I-2xzdG:
undetectable
4p65J-2xzdG:
undetectable		 4p65B-2xzdG:
14.53
4p65D-2xzdG:
14.53
4p65I-2xzdG:
7.46
4p65J-2xzdG:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2xzd DARPIN-3.4
(synthetic
construct) 		5 / 12 LEU G  51
VAL G  30
LEU G  18
ILE G  62
ALA G  71
 None
 1.02A 4p65F-2xzdG:
undetectable
4p65H-2xzdG:
undetectable
4p65K-2xzdG:
undetectable
4p65L-2xzdG:
undetectable		 4p65F-2xzdG:
14.53
4p65H-2xzdG:
14.53
4p65K-2xzdG:
7.46
4p65L-2xzdG:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 2xzd DARPIN-3.4
(synthetic
construct) 		4 / 4 ILE G  62
LEU G  51
HIS G  69
ALA G  71
 None
 0.95A 6ck2C-2xzdG:
undetectable
6ck2D-2xzdG:
undetectable		 6ck2C-2xzdG:
7.46
6ck2D-2xzdG:
13.08