SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xzo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 TRP A 739
TYR A 868
LEU A 708
 None
 1.03A 1kxhA-2xzoA:
undetectable		 1kxhA-2xzoA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 LEU A 489
LEU A 684
LEU A 691
GLY A 692
 None
 0.77A 1n13D-2xzoA:
undetectable
1n13E-2xzoA:
undetectable		 1n13D-2xzoA:
11.46
1n13E-2xzoA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 GLY A 791
ILE A 792
ALA A 828
ILE A 525
 None
None
U  D   4 ( 3.8A)
None
 0.75A 1n49A-2xzoA:
undetectable		 1n49A-2xzoA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 8 THR A 499
GLY A 495
GLN A 665
ARG A 865
 MG  A1006 ( 3.3A)
ADP  A1004 ( 3.2A)
ALF  A1005 (-3.0A)
ALF  A1005 (-3.1A)
 0.92A 1rxcB-2xzoA:
undetectable		 1rxcB-2xzoA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 8 THR A 499
GLY A 495
GLN A 665
ARG A 865
 MG  A1006 ( 3.3A)
ADP  A1004 ( 3.2A)
ALF  A1005 (-3.0A)
ALF  A1005 (-3.1A)
 0.88A 1rxcI-2xzoA:
undetectable		 1rxcI-2xzoA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 ALA A 510
LEU A 539
VAL A 541
LEU A 530
ILE A 658
 None
 1.09A 1s9pA-2xzoA:
undetectable		 1s9pA-2xzoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 8 THR A 496
VAL A 660
GLY A 661
ILE A 696
 ADP  A1004 ( 4.4A)
None
None
None
 0.74A 2a1mB-2xzoA:
undetectable		 2a1mB-2xzoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 11 TYR A 717
GLY A 492
GLY A 661
GLU A 637
GLN A 665
 None
None
None
ALF  A1005 (-3.0A)
ALF  A1005 (-3.0A)
 1.48A 2dr2A-2xzoA:
undetectable		 2dr2A-2xzoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 LEU A 659
SER A 436
PHE A 430
ASP A 433
 None
 1.28A 2vn1B-2xzoA:
undetectable		 2vn1B-2xzoA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 VAL A 310
SER A 419
THR A 616
VAL A 648
ALA A 426
 None
U  D   5 ( 3.5A)
U  D   6 ( 2.8A)
1PE  A1003 ( 4.0A)
1PE  A1003 (-3.6A)
 1.25A 2x2iA-2xzoA:
undetectable		 2x2iA-2xzoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 VAL A 310
SER A 419
THR A 616
VAL A 648
ALA A 426
 None
U  D   5 ( 3.5A)
U  D   6 ( 2.8A)
1PE  A1003 ( 4.0A)
1PE  A1003 (-3.6A)
 1.27A 2x2iC-2xzoA:
undetectable		 2x2iC-2xzoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 GLN A 491
GLY A 492
HIS A 663
CYH A 664
 None
 1.49A 3ai8B-2xzoA:
undetectable		 3ai8B-2xzoA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 5 ILE A 381
TYR A 344
ARG A 341
GLY A 336
 None
 1.30A 3b9mA-2xzoA:
2.3		 3b9mA-2xzoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 VAL A 804
GLU A 797
GLY A 798
ILE A 757
ARG A 843
 None
 1.44A 3bwyA-2xzoA:
4.5		 3bwyA-2xzoA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.36A 3fhjA-2xzoA:
undetectable		 3fhjA-2xzoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.28A 3fhjB-2xzoA:
undetectable		 3fhjB-2xzoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.28A 3fhjC-2xzoA:
undetectable		 3fhjC-2xzoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.29A 3fhjE-2xzoA:
undetectable		 3fhjE-2xzoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.39A 3fi0A-2xzoA:
undetectable		 3fi0A-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.30A 3fi0C-2xzoA:
undetectable		 3fi0C-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.39A 3fi0K-2xzoA:
undetectable		 3fi0K-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.42A 3fi0L-2xzoA:
undetectable		 3fi0L-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.39A 3fi0M-2xzoA:
undetectable		 3fi0M-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.31A 3fi0N-2xzoA:
undetectable		 3fi0N-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.32A 3fi0O-2xzoA:
undetectable		 3fi0O-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 7 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.15A 3fi0P-2xzoA:
undetectable		 3fi0P-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.31A 3fi0R-2xzoA:
undetectable		 3fi0R-2xzoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 VAL A 773
LEU A 813
ILE A 837
ILE A 776
 None
 0.89A 3gcsA-2xzoA:
undetectable		 3gcsA-2xzoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 8 LEU A 544
ALA A 560
HIS A 562
ARG A 624
 None
 0.90A 3kp6A-2xzoA:
undetectable		 3kp6A-2xzoA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 GLY A 495
GLY A 497
THR A 499
 ADP  A1004 ( 3.2A)
ADP  A1004 (-3.2A)
MG  A1006 ( 3.3A)
 0.46A 3si7B-2xzoA:
undetectable		 3si7B-2xzoA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 11 LEU A 347
ILE A 381
ILE A 393
VAL A 411
LEU A 364
 None
 0.94A 3w67A-2xzoA:
undetectable		 3w67A-2xzoA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 VAL A 527
GLU A 637
VAL A 660
ILE A 635
ALA A 620
 None
ALF  A1005 (-3.0A)
None
None
None
 1.12A 4fwdA-2xzoA:
undetectable		 4fwdA-2xzoA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 ILE A 329
THR A 325
VAL A 405
ASP A 369
 None
 1.17A 4iaqA-2xzoA:
2.4		 4iaqA-2xzoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 TYR A 302
VAL A 437
ILE A 441
LEU A 691
LEU A 688
 None
 1.39A 4l1xB-2xzoA:
undetectable		 4l1xB-2xzoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 6 TRP A 739
GLY A 784
PHE A 836
ILE A 790
 None
 1.08A 4qogA-2xzoA:
undetectable
4qogB-2xzoA:
undetectable		 4qogA-2xzoA:
18.53
4qogB-2xzoA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 11 LEU A 659
GLU A 686
LEU A 688
ARG A 485
LEU A 487
 None
 0.99A 4wg0C-2xzoA:
undetectable
4wg0D-2xzoA:
undetectable
4wg0E-2xzoA:
undetectable		 4wg0C-2xzoA:
2.39
4wg0D-2xzoA:
2.39
4wg0E-2xzoA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 11 LEU A 659
GLU A 686
LEU A 688
ARG A 485
LEU A 487
 None
 0.95A 4wg0E-2xzoA:
undetectable
4wg0F-2xzoA:
undetectable
4wg0G-2xzoA:
undetectable		 4wg0E-2xzoA:
2.39
4wg0F-2xzoA:
2.39
4wg0G-2xzoA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 7 ARG A 485
LEU A 487
GLU A 686
LEU A 688
 None
 0.79A 4wg0L-2xzoA:
undetectable
4wg0M-2xzoA:
undetectable		 4wg0L-2xzoA:
2.39
4wg0M-2xzoA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 ALA A 299
TYR A 296
PRO A 644
 None
 0.68A 4zdyA-2xzoA:
undetectable		 4zdyA-2xzoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 1.04A 5jw1B-2xzoA:
undetectable		 5jw1B-2xzoA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 5 SER A 438
VAL A 437
GLY A 653
ALA A 654
 None
 1.02A 5k50A-2xzoA:
2.4		 5k50A-2xzoA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 10 THR A 496
THR A 501
SER A 502
GLY A 492
SER A 638
 ADP  A1004 ( 4.4A)
None
None
None
None
 1.34A 5l66K-2xzoA:
undetectable
5l66L-2xzoA:
undetectable		 5l66K-2xzoA:
15.57
5l66L-2xzoA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 THR A 864
PRO A 494
ASP A 662
 None
ALF  A1005 (-3.6A)
None
 0.90A 5l8dB-2xzoA:
undetectable		 5l8dB-2xzoA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 VAL A 804
GLU A 797
GLY A 798
ILE A 757
ARG A 843
 None
 1.39A 5lsaA-2xzoA:
4.2		 5lsaA-2xzoA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 THR A 864
PRO A 494
ASP A 662
 None
ALF  A1005 (-3.6A)
None
 0.90A 5mwuB-2xzoA:
undetectable		 5mwuB-2xzoA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 8 ILE A 534
VAL A 556
ALA A 521
THR A 616
 None
None
None
U  D   6 ( 2.8A)
 0.77A 5og9A-2xzoA:
undetectable		 5og9A-2xzoA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 LEU A 688
LEU A 445
ILE A 635
LEU A 489
ALA A 654
 None
 1.15A 5og9B-2xzoA:
undetectable		 5og9B-2xzoA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.13A 5v0iA-2xzoA:
undetectable		 5v0iA-2xzoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 9 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.15A 5v0iB-2xzoA:
undetectable		 5v0iB-2xzoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 SER A 812
SER A 810
ALA A 770
 MG  A1007 (-3.0A)
MG  A1007 (-3.9A)
None
 0.59A 6dwnC-2xzoA:
undetectable		 6dwnC-2xzoA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 GLY A 497
VAL A 660
ARG A 703
GLN A 665
GLY A 492
 ADP  A1004 (-3.2A)
None
ALF  A1005 ( 2.8A)
ALF  A1005 (-3.0A)
None
 1.10A 6gneB-2xzoA:
2.4		 6gneB-2xzoA:
22.26