SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 8 ASP A 212
VAL A 139
GLY A 142
GLY A 141
None
0.63A 1ekjE-2y05A:
undetectable
1ekjF-2y05A:
undetectable
1ekjE-2y05A:
20.97
1ekjF-2y05A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 TYR A 181
GLY A 152
ALA A 153
SER A 156
GLY A 159
None
NAP  A 701 (-3.1A)
NAP  A 701 (-3.3A)
None
None
0.98A 1fe2A-2y05A:
undetectable
1fe2A-2y05A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 TYR A 181
GLY A 152
ALA A 153
SER A 156
GLY A 159
None
NAP  A 701 (-3.1A)
NAP  A 701 (-3.3A)
None
None
0.97A 1igxA-2y05A:
undetectable
1igxA-2y05A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 LEU A 322
ASN A 321
GLY A 152
VAL A 154
LEU A 185
None
NAP  A 701 (-3.1A)
NAP  A 701 (-3.1A)
NAP  A 701 (-3.7A)
None
1.29A 1nhzA-2y05A:
undetectable
1nhzA-2y05A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 ALA A 153
GLY A 123
GLY A 120
LEU A 284
LEU A 127
NAP  A 701 (-3.3A)
None
None
None
EDO  A1332 (-3.9A)
1.07A 1rjdB-2y05A:
5.8
1rjdB-2y05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.71A 1usqA-2y05A:
undetectable
1usqA-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.69A 1usqB-2y05A:
undetectable
1usqB-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.70A 1usqC-2y05A:
undetectable
1usqC-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.70A 1usqD-2y05A:
undetectable
1usqD-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.72A 1usqE-2y05A:
undetectable
1usqE-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.70A 1usqF-2y05A:
undetectable
1usqF-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 LEU A 182
ILE A 161
GLY A 171
VAL A 157
LEU A 287
None
1.06A 1vptA-2y05A:
5.5
1vptA-2y05A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 8 TYR A 181
GLY A 159
GLY A 155
ALA A 151
ALA A 150
None
1.38A 2ej3C-2y05A:
undetectable
2ej3C-2y05A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.71A 2jkjA-2y05A:
undetectable
2jkjA-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.70A 2jkjB-2y05A:
undetectable
2jkjB-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.70A 2jkjC-2y05A:
undetectable
2jkjC-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.70A 2jkjE-2y05A:
undetectable
2jkjE-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.67A 2jklA-2y05A:
undetectable
2jklA-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.68A 2jklB-2y05A:
undetectable
2jklB-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.67A 2jklC-2y05A:
undetectable
2jklC-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.68A 2jklD-2y05A:
undetectable
2jklD-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.69A 2jklE-2y05A:
undetectable
2jklE-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 PRO A 252
GLY A 254
PRO A 255
ILE A 227
None
0.68A 2jklF-2y05A:
undetectable
2jklF-2y05A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 ASN A 217
ALA A 149
LEU A 317
THR A 128
PHE A 215
NAP  A 701 (-3.8A)
NAP  A 701 ( 3.9A)
None
NAP  A 701 (-3.1A)
None
1.37A 2oaxC-2y05A:
undetectable
2oaxC-2y05A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 ASN A 217
ALA A 149
LEU A 317
THR A 128
PHE A 215
NAP  A 701 (-3.8A)
NAP  A 701 ( 3.9A)
None
NAP  A 701 (-3.1A)
None
1.34A 2oaxF-2y05A:
undetectable
2oaxF-2y05A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 8 MET A 146
LEU A 203
VAL A 218
GLY A 219
None
None
NAP  A 701 (-4.3A)
None
1.06A 2qd5A-2y05A:
2.8
2qd5A-2y05A:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 TYR A 193
VAL A 218
GLY A 220
SER A 243
NAP  A 701 (-4.2A)
NAP  A 701 (-4.3A)
None
NAP  A 701 (-4.9A)
0.49A 2wekB-2y05A:
35.7
2wekB-2y05A:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 VAL A  46
LEU A  44
THR A  45
ALA A 329
ASN A 308
None
1.18A 3a3bA-2y05A:
undetectable
3a3bA-2y05A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 VAL A 169
VAL A 170
GLN A 229
PHE A 215
None
1.22A 3bjwF-2y05A:
undetectable
3bjwF-2y05A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 5 VAL A 169
VAL A 170
GLN A 229
PHE A 215
None
1.35A 3bjwB-2y05A:
undetectable
3bjwB-2y05A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 GLY A 323
GLY A 319
LEU A 317
SER A 243
ALA A 149
None
NAP  A 701 (-3.4A)
None
NAP  A 701 (-4.9A)
NAP  A 701 ( 3.9A)
1.03A 3kkzB-2y05A:
6.5
3kkzB-2y05A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 ASN A 217
ALA A 149
LEU A 317
THR A 128
PHE A 215
NAP  A 701 (-3.8A)
NAP  A 701 ( 3.9A)
None
NAP  A 701 (-3.1A)
None
1.35A 3vhuA-2y05A:
undetectable
3vhuA-2y05A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 LEU A  86
GLU A 103
LEU A 284
ARG A 280
ILE A 113
None
None
None
EDO  A1332 (-4.3A)
None
1.31A 4j24C-2y05A:
undetectable
4j24C-2y05A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 8 TYR A 214
VAL A 218
LEU A 203
LEU A 199
None
NAP  A 701 (-4.3A)
None
None
1.07A 4jtrA-2y05A:
undetectable
4jtrA-2y05A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
None
None
None
NAP  A 701 (-3.8A)
NAP  A 701 (-3.3A)
0.99A 4obwA-2y05A:
7.9
4obwA-2y05A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
None
None
None
NAP  A 701 (-3.8A)
NAP  A 701 (-3.3A)
1.02A 4obwB-2y05A:
7.7
4obwB-2y05A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
None
None
None
NAP  A 701 (-3.8A)
NAP  A 701 (-3.3A)
0.97A 4obwD-2y05A:
7.3
4obwD-2y05A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
5 / 12 GLY A  60
ILE A 242
TYR A 245
THR A  45
THR A   8
None
NAP  A 701 (-3.8A)
NAP  A 701 (-4.6A)
None
None
1.09A 5eslA-2y05A:
undetectable
5eslA-2y05A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 7 GLY A 171
ALA A 206
ASP A 188
ASN A 148
None
0.97A 5mvsA-2y05A:
6.6
5mvsA-2y05A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 8 GLY A 171
ALA A 206
ASP A 188
ASN A 148
None
0.96A 5mvsB-2y05A:
6.4
5mvsB-2y05A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo
sapiens)
4 / 6 LEU A  38
VAL A  71
THR A  83
LEU A  32
None
0.94A 5tudD-2y05A:
undetectable
5tudD-2y05A:
20.56