SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 11 GLU A 137
ARG A 108
ARG A 104
ALA A 139
GLY A 142
 None
 1.22A 1cmaA-2y0eA:
undetectable
1cmaB-2y0eA:
undetectable		 1cmaA-2y0eA:
14.10
1cmaB-2y0eA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 6 LEU A 278
ALA A 219
SER A 296
THR A 223
 None
 1.06A 1ictB-2y0eA:
undetectable		 1ictB-2y0eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 8 LEU A  13
SER A  67
GLN A  33
ASP A  32
 None
 1.10A 1ig3A-2y0eA:
undetectable
1ig3B-2y0eA:
2.1		 1ig3A-2y0eA:
20.45
1ig3B-2y0eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 6 ALA A 394
LEU A 385
LEU A 328
LEU A 345
 None
 0.93A 1mt1D-2y0eA:
undetectable
1mt1E-2y0eA:
undetectable		 1mt1D-2y0eA:
12.76
1mt1E-2y0eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 LEU A  39
VAL A  44
ILE A  46
CYH A  28
VAL A  54
 None
 1.17A 1s19A-2y0eA:
undetectable		 1s19A-2y0eA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 PHE A 165
HIS A  24
LEU A  64
LEU A  51
LEU A 191
 ACT  A1463 (-3.7A)
None
None
None
None
 1.22A 1zgyA-2y0eA:
undetectable		 1zgyA-2y0eA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 9 LEU A  39
ARG A  59
PHE A  66
LEU A  51
ALA A  56
 None
 1.40A 2bxeA-2y0eA:
undetectable		 2bxeA-2y0eA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 PHE A  81
LEU A   3
VAL A 115
GLU A 186
LEU A 187
 None
None
None
SO4  A1462 ( 4.8A)
None
 1.15A 2bxfA-2y0eA:
undetectable		 2bxfA-2y0eA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		3 / 3 PRO A 413
GLU A 435
TYR A 434
 None
 0.75A 2zmbA-2y0eA:
1.9		 2zmbA-2y0eA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 7 GLY A   7
GLY A   9
THR A  15
ALA A  83
 None
 0.78A 3fpjB-2y0eA:
8.4		 3fpjB-2y0eA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 11 VAL A  84
ALA A  83
PHE A  27
ILE A  82
ARG A  65
 None
 1.23A 3n23A-2y0eA:
undetectable		 3n23A-2y0eA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 MET A 228
LEU A 231
LEU A 234
ALA A 235
GLY A 248
 None
 0.73A 3q95B-2y0eA:
undetectable		 3q95B-2y0eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 7 GLY A 125
ALA A 127
ALA A 132
ARG A 131
 GOL  A1465 ( 4.3A)
None
None
None
 0.85A 3ur0B-2y0eA:
undetectable		 3ur0B-2y0eA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 LEU A 100
GLU A 136
ALA A 102
GLU A 137
ASN A 105
 None
 1.34A 4cpzA-2y0eA:
undetectable		 4cpzA-2y0eA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 LEU A 100
GLU A 136
ALA A 102
GLU A 137
ASN A 105
 None
 1.28A 4cpzB-2y0eA:
undetectable		 4cpzB-2y0eA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 LEU A 100
GLU A 136
ALA A 102
GLU A 137
ASN A 105
 None
 1.29A 4cpzD-2y0eA:
undetectable		 4cpzD-2y0eA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 GLU A 136
ALA A 102
GLU A 137
ARG A 108
ASN A 105
 None
 1.30A 4cpzF-2y0eA:
undetectable		 4cpzF-2y0eA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		3 / 3 LYS A 331
THR A 334
ILE A  46
 UGA  A 501 (-2.7A)
None
None
 0.91A 4e0fB-2y0eA:
undetectable		 4e0fB-2y0eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 MET A 228
LEU A 231
LEU A 234
ALA A 235
GLY A 248
 None
 0.74A 4pxmA-2y0eA:
undetectable		 4pxmA-2y0eA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 6 SER A 269
LYS A 331
PHE A 330
TRP A 407
 None
UGA  A 501 (-2.7A)
UGA  A 501 (-4.7A)
None
 1.14A 5dlvA-2y0eA:
0.0		 5dlvA-2y0eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 7 SER A 269
LYS A 331
PHE A 330
TRP A 407
 None
UGA  A 501 (-2.7A)
UGA  A 501 (-4.7A)
None
 1.12A 5dlvB-2y0eA:
undetectable		 5dlvB-2y0eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 VAL A  14
ALA A  20
PRO A  45
ALA A  17
GLY A  16
 None
 1.38A 5tzoA-2y0eA:
undetectable		 5tzoA-2y0eA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		5 / 12 VAL A  14
ALA A  20
PRO A  45
ALA A  17
GLY A  16
 None
 1.34A 5tzoC-2y0eA:
undetectable		 5tzoC-2y0eA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		3 / 3 PHE A 330
ASP A 335
LEU A 373
 UGA  A 501 (-4.7A)
None
None
 0.79A 5uhbC-2y0eA:
undetectable		 5uhbC-2y0eA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 8 PHE A  81
ILE A   5
ASN A 152
PHE A 165
 None
None
None
ACT  A1463 (-3.7A)
 1.13A 5x23A-2y0eA:
undetectable		 5x23A-2y0eA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 5 ARG A 237
ALA A 235
GLN A 302
ILE A 449
 None
 1.26A 6g9bA-2y0eA:
undetectable
6g9bB-2y0eA:
undetectable		 6g9bA-2y0eA:
11.46
6g9bB-2y0eA:
10.17