SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 8 PRO A 113
LEU A 180
GLY A 198
LEU A 150
 None
 0.77A 1ya4A-2y0hA:
undetectable		 1ya4A-2y0hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 113
LEU A 180
GLY A 198
LEU A 150
 None
 0.79A 1ya4B-2y0hA:
undetectable		 1ya4B-2y0hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 365
ILE A 367
GLU A 379
ARG A 381
ARG A 323
 None
 1.29A 2f10A-2y0hA:
undetectable		 2f10A-2y0hA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 278
GLY A 279
THR A 155
SER A 161
 None
 1.25A 2o5yH-2y0hA:
undetectable
2o5yL-2y0hA:
undetectable		 2o5yH-2y0hA:
18.25
2o5yL-2y0hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 238
ILE A 239
ARG A 169
HIS A 173
 None
 1.01A 3v4tH-2y0hA:
undetectable		 3v4tH-2y0hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 208
SER A 194
GLY A 182
ALA A 118
 None
 0.93A 4m48A-2y0hA:
undetectable		 4m48A-2y0hA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 385
SER A 349
ALA A 361
VAL A 360
 None
 1.33A 4x1kC-2y0hA:
undetectable		 4x1kC-2y0hA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 385
SER A 349
ALA A 361
VAL A 360
 None
 1.16A 5nm5A-2y0hA:
undetectable		 5nm5A-2y0hA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 THR A 346
ASP A 347
LEU A 320
ASP A 307
 None
 1.19A 5tdzA-2y0hA:
undetectable		 5tdzA-2y0hA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 MET A 321
GLU A 343
ARG A 323
 None
 0.90A 5tjzA-2y0hA:
undetectable		 5tjzA-2y0hA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 GLY A  59
THR A 281
PRO A 127
 C8E  A1402 (-3.7A)
None
None
 0.57A 5v5zA-2y0hA:
undetectable		 5v5zA-2y0hA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 2y0h PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 365
ILE A 367
GLU A 379
ARG A 381
ARG A 323
 None
 1.33A 6ekuA-2y0hA:
undetectable		 6ekuA-2y0hA:
20.13