SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 167
GLY A 286
ASP A 287
 None
 0.54A 1kf6A-2y0kA:
undetectable
1kf6B-2y0kA:
undetectable		 1kf6A-2y0kA:
21.46
1kf6B-2y0kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 288
ASN A 281
PHE A 366
GLY A 289
VAL A 324
 None
 1.42A 2fqyA-2y0kA:
undetectable		 2fqyA-2y0kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 270
ILE A 168
ARG A 167
ASP A 267
 None
 1.34A 2rhmB-2y0kA:
undetectable		 2rhmB-2y0kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 270
ILE A 168
ARG A 167
ASP A 267
 None
 1.37A 2rhmD-2y0kA:
undetectable		 2rhmD-2y0kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 11 TYR A 182
GLY A 141
ASP A 140
ILE A 139
GLN A 137
 None
 1.25A 3id5B-2y0kA:
undetectable		 3id5B-2y0kA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 11 TYR A 182
GLY A 141
ASP A 140
ILE A 139
GLN A 137
 None
 1.24A 3id5F-2y0kA:
undetectable		 3id5F-2y0kA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 11 GLU A 336
ASN A 290
GLU A 293
VAL A 319
VAL A 362
 None
 1.45A 3qwuB-2y0kA:
undetectable		 3qwuB-2y0kA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 203
LEU A 279
ALA A 242
ALA A 229
ILE A 263
 None
 1.19A 3ut5D-2y0kA:
undetectable		 3ut5D-2y0kA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		3 / 3 GLN A  86
ASP A 159
GLN A 161
 None
 0.43A 4aztA-2y0kA:
undetectable		 4aztA-2y0kA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 337
ARG A  22
ASP A 371
ASP A 369
 None
 1.14A 4kcnA-2y0kA:
undetectable		 4kcnA-2y0kA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  61
GLY A  36
LEU A  59
LEU A  38
LYS A  91
 None
 1.13A 4lg1B-2y0kA:
undetectable		 4lg1B-2y0kA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		4 / 6 SER A 172
GLY A 195
ASP A 232
ASP A 176
 None
 1.06A 4uckB-2y0kA:
undetectable		 4uckB-2y0kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  17
ALA A  30
LEU A 370
PHE A  21
 None
 1.05A 4uymA-2y0kA:
undetectable		 4uymA-2y0kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  17
ALA A  30
LEU A 370
PHE A  21
 None
 1.14A 4uymB-2y0kA:
undetectable		 4uymB-2y0kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 362
ALA A 360
ASN A 359
GLN A 284
 None
 1.27A 4zgfA-2y0kA:
undetectable		 4zgfA-2y0kA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 11 TYR A  89
SER A 156
GLU A  11
GLU A  32
GLY A  61
 None
 1.42A 4zjoD-2y0kA:
undetectable		 4zjoD-2y0kA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 124
LEU A  38
LEU A  60
GLY A  93
LEU A 128
 None
 1.22A 5dxgB-2y0kA:
undetectable		 5dxgB-2y0kA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 298
ALA A 257
SER A 248
ARG A 225
GLY A 244
 C8E  A1390 (-3.9A)
None
None
None
None
 1.20A 5m5cB-2y0kA:
undetectable		 5m5cB-2y0kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		3 / 3 MET A 315
GLU A 336
ARG A 317
 None
 0.97A 5tjzA-2y0kA:
undetectable		 5tjzA-2y0kA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 177
GLY A 146
VAL A 107
GLY A 195
ALA A 174
 None
 0.98A 6c2mA-2y0kA:
undetectable		 6c2mA-2y0kA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 177
GLY A 146
VAL A 107
GLY A 195
ALA A 174
 None
 0.97A 6c2mB-2y0kA:
undetectable		 6c2mB-2y0kA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2y0k PYROGLUTATMATE PORIN
OPDO
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 201
ALA A 227
LEU A 116
 None
 0.68A 6d9kF-2y0kA:
undetectable		 6d9kF-2y0kA:
22.08