SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1
(Homo
sapiens) 		5 / 10 LEU A 263
VAL A 280
VAL A 251
TYR A 259
GLY A 253
 None
 1.47A 1fkoA-2y0mA:
undetectable		 1fkoA-2y0mA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1
(Homo
sapiens) 		5 / 12 LEU A 263
CYH A 264
LEU A 266
ALA A 267
LEU A 318
 None
ALY  A 274 ( 3.4A)
None
ALY  A 274 ( 4.0A)
ACO  A1450 (-4.2A)
 0.81A 1s9pC-2y0mA:
undetectable		 1s9pC-2y0mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1
(Homo
sapiens) 		3 / 3 ARG A 326
ASP A 292
GLN A 294
 None
 0.91A 4azsA-2y0mA:
undetectable		 4azsA-2y0mA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1
(Homo
sapiens) 		5 / 12 TYR A 212
ILE A 184
GLY A 185
HIS A 297
ILE A 298
 None
 1.13A 4rvdA-2y0mA:
undetectable		 4rvdA-2y0mA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1
(Homo
sapiens) 		5 / 12 TYR A 212
ILE A 184
GLY A 185
HIS A 297
ILE A 298
 None
 1.14A 4rvgA-2y0mA:
undetectable		 4rvgA-2y0mA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2y0m MALE-SPECIFIC LETHAL
1 HOMOLOG
(Mus
musculus) 		3 / 3 LYS B 507
ARG B 508
HIS B 509
 None
 1.24A 4zbrA-2y0mB:
undetectable		 4zbrA-2y0mB:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1
(Homo
sapiens) 		5 / 12 LEU A 271
TYR A 301
GLY A 300
ALA A 267
GLU A 290
 ALY  A 274 (-4.3A)
ALY  A 274 ( 4.8A)
None
ALY  A 274 ( 4.0A)
None
 1.04A 5x6yC-2y0mA:
undetectable		 5x6yC-2y0mA:
16.44