SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2y0n MALE-SPECIFIC LETHAL
1 HOMOLOG
MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens;
Mus
musculus) 		5 / 9 LEU A 463
LEU A 261
ALA A 479
LEU A 477
PHE E 577
 None
 1.08A 1tbfA-2y0nA:
undetectable		 1tbfA-2y0nA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2y0n MALE-SPECIFIC LETHAL
1 HOMOLOG
MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens;
Mus
musculus) 		4 / 5 PHE E 577
LEU A 459
PHE A 472
MET A 470
 None
 1.33A 1wrkB-2y0nE:
undetectable		 1wrkB-2y0nE:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2y0n MALE-SPECIFIC LETHAL
1 HOMOLOG
MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens;
Mus
musculus) 		4 / 5 PHE E 577
LEU A 459
PHE A 472
MET A 470
 None
 1.29A 1wrlC-2y0nE:
undetectable		 1wrlC-2y0nE:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 8 PHE A 487
LEU A 210
TYR A 213
LEU A 463
 None
 1.01A 2bfpD-2y0nA:
undetectable		 2bfpD-2y0nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 8 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.88A 2eilP-2y0nA:
undetectable
2eilW-2y0nA:
undetectable		 2eilP-2y0nA:
18.22
2eilW-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 7 ARG A 196
ASP A 187
GLY A 452
PRO A 500
 None
 0.81A 2fxdB-2y0nA:
undetectable		 2fxdB-2y0nA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 174
LEU A 456
PHE A 487
PHE A 484
THR A 264
 None
 0.92A 2w3bA-2y0nA:
undetectable		 2w3bA-2y0nA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 8 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.91A 3asoC-2y0nA:
undetectable
3asoJ-2y0nA:
undetectable		 3asoC-2y0nA:
18.22
3asoJ-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 8 TYR A 494
GLU A 493
SER A 212
ILE A 209
 None
 0.95A 3jz0B-2y0nA:
undetectable		 3jz0B-2y0nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 6 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.92A 3wg7P-2y0nA:
undetectable
3wg7W-2y0nA:
undetectable		 3wg7P-2y0nA:
18.22
3wg7W-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2y0n MALE-SPECIFIC LETHAL
1 HOMOLOG
MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens;
Mus
musculus) 		5 / 12 PRO E 582
LEU E 584
LEU A 459
ILE A 466
PHE A 460
 None
 1.15A 4a79A-2y0nE:
undetectable		 4a79A-2y0nE:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2y0n MALE-SPECIFIC LETHAL
1 HOMOLOG
MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens;
Mus
musculus) 		5 / 12 PRO E 582
LEU E 584
LEU A 459
ILE A 466
PHE A 460
 None
 1.13A 4a79B-2y0nE:
undetectable		 4a79B-2y0nE:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2y0n MALE-SPECIFIC LETHAL
1 HOMOLOG
MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens;
Mus
musculus) 		5 / 12 PRO E 582
LEU E 584
LEU A 459
ILE A 466
PHE A 460
 None
 1.14A 4a7aB-2y0nE:
undetectable		 4a7aB-2y0nE:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		3 / 3 TYR A 449
ARG A 262
SER A 448
 None
 1.17A 4dr2I-2y0nA:
undetectable
4dr2J-2y0nA:
undetectable		 4dr2I-2y0nA:
20.56
4dr2J-2y0nA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 174
LEU A 456
PHE A 487
PHE A 484
THR A 264
 None
 0.92A 4kebB-2y0nA:
undetectable		 4kebB-2y0nA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 174
LEU A 456
PHE A 487
PHE A 484
THR A 264
 None
 0.96A 4m6kA-2y0nA:
undetectable		 4m6kA-2y0nA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.95A 5b1aC-2y0nA:
undetectable
5b1aJ-2y0nA:
undetectable		 5b1aC-2y0nA:
18.22
5b1aJ-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.96A 5b1aP-2y0nA:
undetectable
5b1aW-2y0nA:
undetectable		 5b1aP-2y0nA:
18.22
5b1aW-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.91A 5iy5C-2y0nA:
undetectable
5iy5J-2y0nA:
undetectable		 5iy5C-2y0nA:
17.98
5iy5J-2y0nA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.88A 5x19C-2y0nA:
undetectable
5x19J-2y0nA:
undetectable		 5x19C-2y0nA:
18.22
5x19J-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.95A 5z84C-2y0nA:
undetectable
5z84J-2y0nA:
undetectable		 5z84C-2y0nA:
18.22
5z84J-2y0nA:
17.44