SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 5 PHE A 162
TYR A  32
LEU A  42
ASP A 160
 None
 1.22A 1dz6A-2y0oA:
undetectable		 1dz6A-2y0oA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		3 / 3 GLU A  82
HIS A 137
HIS A  71
 ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.4A)
 0.54A 1oe2A-2y0oA:
1.6		 1oe2A-2y0oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 5 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.02A 1os2A-2y0oA:
undetectable		 1os2A-2y0oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.02A 1os2D-2y0oA:
undetectable		 1os2D-2y0oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 12 GLU A 150
LEU A  42
MET A  30
TYR A  32
GLN A  28
 ARS  A1176 (-4.1A)
None
None
None
None
 1.16A 1p5zB-2y0oA:
undetectable		 1p5zB-2y0oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 7 GLU A 150
GLU A  82
ILE A 131
LEU A  42
 ARS  A1176 (-4.1A)
ZN  A1173 (-2.6A)
None
None
 1.33A 1q0yH-2y0oA:
undetectable
1q0yL-2y0oA:
undetectable		 1q0yH-2y0oA:
20.91
1q0yL-2y0oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.09A 1uttA-2y0oA:
undetectable		 1uttA-2y0oA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.04A 1utzA-2y0oA:
undetectable		 1utzA-2y0oA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.07A 1utzB-2y0oA:
undetectable		 1utzB-2y0oA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 11 LEU A  44
HIS A 137
HIS A  69
HIS A  71
GLU A  82
 None
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
 1.01A 2dttD-2y0oA:
undetectable
2dttE-2y0oA:
undetectable		 2dttD-2y0oA:
20.93
2dttE-2y0oA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.04A 2hu6A-2y0oA:
undetectable		 2hu6A-2y0oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 12 GLU A 150
LEU A  42
MET A  30
TYR A  32
GLN A  28
 ARS  A1176 (-4.1A)
None
None
None
None
 1.18A 2no0A-2y0oA:
undetectable		 2no0A-2y0oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 12 GLU A 150
LEU A  42
MET A  30
TYR A  32
GLN A  28
 ARS  A1176 (-4.1A)
None
None
None
None
 1.20A 2no0B-2y0oA:
undetectable		 2no0B-2y0oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_A_ETVA302_1
(DEOXYCYTIDINE KINASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 12 GLU A 150
LEU A  42
MET A  30
TYR A  32
GLN A  28
 ARS  A1176 (-4.1A)
None
None
None
None
 1.22A 2no6A-2y0oA:
undetectable		 2no6A-2y0oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 11 GLU A 150
LEU A  42
MET A  30
TYR A  32
GLN A  28
 ARS  A1176 (-4.1A)
None
None
None
None
 1.29A 2no6B-2y0oA:
undetectable		 2no6B-2y0oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 12 GLU A 150
LEU A  42
MET A  30
TYR A  32
GLN A  28
 ARS  A1176 (-4.1A)
None
None
None
None
 1.22A 2noaA-2y0oA:
undetectable		 2noaA-2y0oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 6 LEU A  58
HIS A 137
GLU A  82
HIS A  71
HIS A  69
 None
ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 0.98A 2ow9A-2y0oA:
undetectable		 2ow9A-2y0oA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.04A 2ow9B-2y0oA:
undetectable		 2ow9B-2y0oA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.03A 2ozrC-2y0oA:
undetectable		 2ozrC-2y0oA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.04A 2ozrD-2y0oA:
undetectable		 2ozrD-2y0oA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 5 LEU A  58
HIS A 137
GLU A  82
HIS A  71
HIS A  69
 None
ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.02A 3kecA-2y0oA:
undetectable		 3kecA-2y0oA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 5 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.04A 3likA-2y0oA:
undetectable		 3likA-2y0oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.05A 3lilA-2y0oA:
undetectable		 3lilA-2y0oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 5 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.02A 3ljgA-2y0oA:
undetectable		 3ljgA-2y0oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 5 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.03A 3lkaA-2y0oA:
undetectable		 3lkaA-2y0oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		3 / 3 LYS A 136
GLU A  68
TRP A 118
 None
 1.03A 3v4tH-2y0oA:
undetectable		 3v4tH-2y0oA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 6 LEU A  58
HIS A 137
GLU A  82
HIS A  71
HIS A  69
 None
ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 0.97A 4a7bA-2y0oA:
undetectable		 4a7bA-2y0oA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 5 LEU A  58
HIS A 137
GLU A  82
HIS A  71
 None
ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
 0.95A 4a7bB-2y0oA:
undetectable		 4a7bB-2y0oA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		5 / 12 LEU A  19
ILE A  17
TYR A  12
GLN A  28
MET A 151
 None
 1.08A 4a83A-2y0oA:
undetectable		 4a83A-2y0oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 7 ASN A   9
GLU A   6
GLU A   7
TYR A  11
 None
 1.36A 4mj8C-2y0oA:
undetectable		 4mj8C-2y0oA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 4 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.05A 5n5jA-2y0oA:
undetectable		 5n5jA-2y0oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		4 / 5 HIS A 137
GLU A  82
HIS A  71
HIS A  69
 ZN  A1173 (-3.4A)
ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.6A)
 1.02A 5n5kA-2y0oA:
undetectable		 5n5kA-2y0oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		3 / 3 HIS A  69
HIS A 137
HIS A  71
 ZN  A1173 (-3.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.4A)
 0.44A 5zrdA-2y0oA:
undetectable		 5zrdA-2y0oA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE
(Bacillus
subtilis) 		3 / 3 GLY A   2
THR A   4
GLU A   7
 None
 0.64A 6b58A-2y0oA:
undetectable		 6b58A-2y0oA:
16.15