SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2y0s RNA POLYMERASE
SUBUNIT 8
(Sulfolobus
shibatae) 		3 / 3 SER G  60
PHE G  58
LYS G 114
 None
 0.94A 3u88A-2y0sG:
undetectable		 3u88A-2y0sG:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2y0s RNA POLYMERASE
SUBUNIT 4
(Sulfolobus
shibatae) 		5 / 11 LEU E 169
ALA E 144
LEU E 162
ILE E 110
GLY E  96
 None
 1.19A 4pxmB-2y0sE:
undetectable		 4pxmB-2y0sE:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2y0s RNA POLYMERASE
SUBUNIT 4
(Sulfolobus
shibatae) 		5 / 6 ILE E  13
VAL E  70
TYR E  67
VAL E  11
SER E  54
 None
 1.18A 5jwaH-2y0sE:
undetectable		 5jwaH-2y0sE:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2y0s RNA POLYMERASE
SUBUNIT 8
(Sulfolobus
shibatae) 		5 / 12 PHE G  71
LEU G  26
ILE G  28
ILE G  29
PHE G  49
 None
 1.36A 5uanB-2y0sG:
undetectable		 5uanB-2y0sG:
15.46