SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y1h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		4 / 5 HIS A  12
HIS A  70
HIS A 147
ASP A 218
 ZN  A1274 ( 3.2A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
PO4  A1275 ( 2.7A)
 0.65A 1e9yB-2y1hA:
14.3		 1e9yB-2y1hA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 6 HIS A  12
HIS A  14
HIS A  70
HIS A 147
ASP A 218
 ZN  A1274 ( 3.2A)
ZN  A1274 ( 3.3A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
PO4  A1275 ( 2.7A)
 0.64A 1fweC-2y1hA:
12.7		 1fweC-2y1hA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 12 LEU A 130
HIS A 147
SER A 190
THR A 155
GLY A 174
 None
ZN  A1273 ( 3.1A)
None
None
None
 1.29A 1ia0B-2y1hA:
0.0		 1ia0B-2y1hA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 12 GLU A 107
HIS A  70
HIS A 147
HIS A 170
ASP A 218
 ZN  A1274 (-2.4A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
ZN  A1273 (-3.2A)
PO4  A1275 ( 2.7A)
 1.00A 1ituA-2y1hA:
14.7		 1ituA-2y1hA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 12 GLU A 107
HIS A  70
HIS A 147
HIS A 170
ASP A 218
 ZN  A1274 (-2.4A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
ZN  A1273 (-3.2A)
PO4  A1275 ( 2.7A)
 1.02A 1ituB-2y1hA:
14.7		 1ituB-2y1hA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 12 LEU A 130
HIS A 147
SER A 190
THR A 155
GLY A 174
 None
ZN  A1273 ( 3.1A)
None
None
None
 1.29A 1tubB-2y1hA:
undetectable		 1tubB-2y1hA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		4 / 7 GLU A 225
TRP A 233
PRO A 232
GLY A 223
 None
 1.30A 2hs1B-2y1hA:
undetectable		 2hs1B-2y1hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		3 / 3 GLU A  44
HIS A 147
GLU A 107
 PO4  A1275 (-3.2A)
ZN  A1273 ( 3.1A)
ZN  A1274 (-2.4A)
 0.80A 2x45B-2y1hA:
undetectable		 2x45B-2y1hA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		3 / 3 GLU A  44
HIS A 147
GLU A 107
 PO4  A1275 (-3.2A)
ZN  A1273 ( 3.1A)
ZN  A1274 (-2.4A)
 0.79A 2x45C-2y1hA:
undetectable		 2x45C-2y1hA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		4 / 7 LEU A 210
GLU A 252
ILE A 242
ALA A  34
 None
 0.72A 2xkwA-2y1hA:
undetectable		 2xkwA-2y1hA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		3 / 3 VAL A 146
SER A 148
LEU A 169
 None
 0.60A 3n8xA-2y1hA:
undetectable		 3n8xA-2y1hA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		4 / 5 THR A 155
ILE A 156
GLU A 181
PHE A 189
 None
 1.42A 4ac9C-2y1hA:
3.5		 4ac9C-2y1hA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		4 / 5 THR A 155
ILE A 156
GLU A 181
PHE A 189
 None
 1.43A 4acaC-2y1hA:
3.1		 4acaC-2y1hA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		4 / 5 THR A 155
ILE A 156
GLU A 181
PHE A 189
 None
 1.38A 4acbC-2y1hA:
4.0		 4acbC-2y1hA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		4 / 5 HIS A  12
HIS A  70
HIS A 147
ASP A 218
 ZN  A1274 ( 3.2A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
PO4  A1275 ( 2.7A)
 0.56A 4h9mA-2y1hA:
5.7		 4h9mA-2y1hA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 11 HIS A 170
ARG A 149
GLU A 107
HIS A  14
ALA A 221
 ZN  A1273 (-3.2A)
PO4  A1275 ( 4.9A)
ZN  A1274 (-2.4A)
ZN  A1274 ( 3.3A)
PO4  A1275 ( 4.5A)
 1.12A 4ir0A-2y1hA:
undetectable
4ir0B-2y1hA:
undetectable		 4ir0A-2y1hA:
19.08
4ir0B-2y1hA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 11 HIS A  14
ALA A 221
HIS A 170
ARG A 149
GLU A 107
 ZN  A1274 ( 3.3A)
PO4  A1275 ( 4.5A)
ZN  A1273 (-3.2A)
PO4  A1275 ( 4.9A)
ZN  A1274 (-2.4A)
 1.15A 4jh4A-2y1hA:
undetectable
4jh4B-2y1hA:
undetectable		 4jh4A-2y1hA:
18.61
4jh4B-2y1hA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 11 PHE A  49
GLY A 106
GLY A  68
HIS A 147
HIS A  12
 None
None
None
ZN  A1273 ( 3.1A)
ZN  A1274 ( 3.2A)
 1.13A 4l8fB-2y1hA:
undetectable		 4l8fB-2y1hA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 11 PHE A  49
GLY A 106
GLY A  68
HIS A 147
HIS A  12
 None
None
None
ZN  A1273 ( 3.1A)
ZN  A1274 ( 3.2A)
 1.11A 4l8fD-2y1hA:
undetectable		 4l8fD-2y1hA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 6 HIS A  12
HIS A  14
HIS A  70
HIS A 147
ASP A 218
 ZN  A1274 ( 3.2A)
ZN  A1274 ( 3.3A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
PO4  A1275 ( 2.7A)
 0.54A 4ubpC-2y1hA:
14.5		 4ubpC-2y1hA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		5 / 6 HIS A  14
HIS A  70
HIS A 147
HIS A 170
ASP A 218
 ZN  A1274 ( 3.3A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
ZN  A1273 (-3.2A)
PO4  A1275 ( 2.7A)
 0.99A 4ubpC-2y1hA:
14.5		 4ubpC-2y1hA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		4 / 6 LEU A  24
CYH A  13
HIS A  14
LEU A  15
 None
None
ZN  A1274 ( 3.3A)
None
 0.99A 5hpuC-2y1hA:
undetectable
5hpuD-2y1hA:
undetectable		 5hpuC-2y1hA:
5.51
5hpuD-2y1hA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens) 		4 / 5 HIS A  14
HIS A  12
HIS A  70
VAL A  42
 ZN  A1274 ( 3.3A)
ZN  A1274 ( 3.2A)
PO4  A1275 (-3.8A)
None
 1.20A 5i3bB-2y1hA:
undetectable		 5i3bB-2y1hA:
20.63