SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJL_A_SAMA200_0 (METHIONINE REPRESSOR PROTEIN METJ)	2y1l	DARPIN-8.4 (synthetic construct)	5 / 11	ALA E 71 HIS E 52 GLU E 64 ALA E 55 LEU E 99	None	1.31A	1mjlA-2y1lE: undetectable 1mjlB-2y1lE: undetectable	1mjlA-2y1lE: 19.32 1mjlB-2y1lE: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJL_A_SAMA200_0 (METHIONINE REPRESSOR PROTEIN METJ)	2y1l	DARPIN-8.4 (synthetic construct)	5 / 11	ALA E 71 HIS E 52 GLU E 64 LEU E 60 LEU E 99	None	1.13A	1mjlA-2y1lE: undetectable 1mjlB-2y1lE: undetectable	1mjlA-2y1lE: 19.32 1mjlB-2y1lE: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y8W_C_STRC603_2 (CYTOCHROME P450 21-HYDROXYLASE)	2y1l	DARPIN-8.4 (synthetic construct)	3 / 3	LEU E 53 VAL E 40 ASP E 39	EDO E1169 (-4.3A) None None	0.71A	4y8wC-2y1lE: undetectable	4y8wC-2y1lE: 17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ALC_L_TIQL1210_2 (ANTI-TICAGRELOR FAB 72, LIGHT CHAIN)	2y1l	DARPIN-8.4 (synthetic construct)	4 / 8	GLY E 91 ILE E 152 SER E 153 GLY E 124	None	0.85A	5alcL-2y1lE: undetectable	5alcL-2y1lE: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HYR_A_ESTA601_1 (ESTROGEN RECEPTOR)	2y1l	DARPIN-8.4 (synthetic construct)	5 / 10	LEU E 126 ALA E 120 LEU E 132 LEU E 133 LEU E 93	None	1.49A	5hyrA-2y1lE: undetectable	5hyrA-2y1lE: 21.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MJL_A_SAMA200_0","METHIONINE REPRESSOR PROTEIN METJ","2y1l","DARPIN-8.4","synthetic construct",5,"ALA E  71;HIS E  52;GLU E  64;ALA E  55;LEU E  99","None","1.31A","1mjlA-2y1lE:undetectable;1mjlB-2y1lE:undetectable","1mjlA-2y1lE:19.32;1mjlB-2y1lE:19.32"],["1MJL_A_SAMA200_0","METHIONINE REPRESSOR PROTEIN METJ","2y1l","DARPIN-8.4","synthetic construct",5,"ALA E  71;HIS E  52;GLU E  64;LEU E  60;LEU E  99","None","1.13A","1mjlA-2y1lE:undetectable;1mjlB-2y1lE:undetectable","1mjlA-2y1lE:19.32;1mjlB-2y1lE:19.32"],["4Y8W_C_STRC603_2","CYTOCHROME P450 21-HYDROXYLASE","2y1l","DARPIN-8.4","synthetic construct",3,"LEU E  53;VAL E  40;ASP E  39","EDO E1169 (-4.3A);None;None","0.71A","4y8wC-2y1lE:undetectable","4y8wC-2y1lE:17.90"],["5ALC_L_TIQL1210_2","ANTI-TICAGRELOR FAB 72, LIGHT CHAIN","2y1l","DARPIN-8.4","synthetic construct",4,"GLY E  91;ILE E 152;SER E 153;GLY E 124","None","0.85A","5alcL-2y1lE:undetectable","5alcL-2y1lE:21.24"],["5HYR_A_ESTA601_1","ESTROGEN RECEPTOR","2y1l","DARPIN-8.4","synthetic construct",5,"LEU E 126;ALA E 120;LEU E 132;LEU E 133;LEU E  93","None","1.49A","5hyrA-2y1lE:undetectable","5hyrA-2y1lE:21.34"]]