SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_D_TRPD81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	2y25	MYOMESIN (Homo sapiens)	4 / 7	SER A1462 VAL A1368 GLY A1370 THR A1482	None	0.76A	1gtnC-2y25A: undetectable 1gtnD-2y25A: undetectable	1gtnC-2y25A: 14.05 1gtnD-2y25A: 14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDU_A_CIAA1003_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	2y25	MYOMESIN (Homo sapiens)	5 / 11	SER A1657 ILE A1584 VAL A1582 LEU A1578 PHE A1631	None	1.24A	1uduA-2y25A: undetectable	1uduA-2y25A: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDU_B_CIAB2003_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	2y25	MYOMESIN (Homo sapiens)	5 / 12	ILE A1633 ILE A1584 VAL A1582 LEU A1578 PHE A1631	None	1.02A	1uduB-2y25A: undetectable	1uduB-2y25A: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DRJ_A_RAPA201_2 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4 SERINE/THREONINE-PRO TEIN KINASE MTOR)	2y25	MYOMESIN (Homo sapiens)	4 / 8	LEU A1592 THR A1656 ASP A1658 TYR A1644	None	1.05A	4drjB-2y25A: undetectable	4drjB-2y25A: 22.02

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GTN_D_TRPD81_0","TRP RNA-BINDING ATTENUATION PROTEIN","2y25","MYOMESIN","Homo sapiens",4,"SER A1462;VAL A1368;GLY A1370;THR A1482","None","0.76A","1gtnC-2y25A:undetectable;1gtnD-2y25A:undetectable","1gtnC-2y25A:14.05;1gtnD-2y25A:14.05"],["1UDU_A_CIAA1003_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","2y25","MYOMESIN","Homo sapiens",5,"SER A1657;ILE A1584;VAL A1582;LEU A1578;PHE A1631","None","1.24A","1uduA-2y25A:undetectable","1uduA-2y25A:21.58"],["1UDU_B_CIAB2003_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","2y25","MYOMESIN","Homo sapiens",5,"ILE A1633;ILE A1584;VAL A1582;LEU A1578;PHE A1631","None","1.02A","1uduB-2y25A:undetectable","1uduB-2y25A:21.58"],["4DRJ_A_RAPA201_2","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4;SERINE\/THREONINE-PROTEIN KINASE MTOR","2y25","MYOMESIN","Homo sapiens",4,"LEU A1592;THR A1656;ASP A1658;TYR A1644","None","1.05A","4drjB-2y25A:undetectable","4drjB-2y25A:22.02"]]