SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 THR A 184
GLY A 421
GLY A 144
GLY A 162
 None
 0.64A 1d0vA-2y27A:
undetectable		 1d0vA-2y27A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 THR A 184
GLY A 421
GLY A 144
GLY A 162
 None
 0.63A 1jhaA-2y27A:
undetectable		 1jhaA-2y27A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 THR A 184
GLY A 421
GLY A 144
GLY A 162
 None
 0.64A 1jhqA-2y27A:
undetectable		 1jhqA-2y27A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 THR A 184
GLY A 421
GLY A 144
GLY A 162
 None
 0.60A 1jhvA-2y27A:
undetectable		 1jhvA-2y27A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 GLU A 250
ILE A 209
ALA A 123
ARG A 222
GLU A 226
 None
 0.97A 1ki7A-2y27A:
undetectable		 1ki7A-2y27A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 GLU A 250
ILE A 209
ALA A 123
ARG A 222
GLU A 226
 None
 1.14A 1ki7B-2y27A:
undetectable		 1ki7B-2y27A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 4 SER A  37
LEU A 296
TYR A  40
GLY A  78
 None
 1.50A 1liiA-2y27A:
undetectable		 1liiA-2y27A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		3 / 3 TYR A 187
ARG A 197
GLN A 198
 None
 0.97A 1tw4A-2y27A:
undetectable		 1tw4A-2y27A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.86A 1usqA-2y27A:
undetectable		 1usqA-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.85A 1usqB-2y27A:
undetectable		 1usqB-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 TYR A 301
THR A 101
GLY A  95
THR A  96
 None
None
ATP  A 508 (-3.2A)
ATP  A 508 (-3.3A)
 0.87A 2a1hA-2y27A:
undetectable
2a1hB-2y27A:
undetectable		 2a1hA-2y27A:
22.87
2a1hB-2y27A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.81A 2jkjA-2y27A:
undetectable		 2jkjA-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.80A 2jkjB-2y27A:
undetectable		 2jkjB-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.81A 2jkjC-2y27A:
undetectable		 2jkjC-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.80A 2jkjE-2y27A:
undetectable		 2jkjE-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.83A 2jklA-2y27A:
undetectable		 2jklA-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.82A 2jklB-2y27A:
undetectable		 2jklB-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.83A 2jklC-2y27A:
undetectable		 2jklC-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.83A 2jklE-2y27A:
undetectable		 2jklE-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 244
PRO A 245
ILE A 236
GLY A 238
 GOL  A 505 (-3.9A)
GOL  A 505 (-3.7A)
GOL  A 505 ( 4.5A)
GOL  A 505 ( 3.4A)
 0.84A 2jklF-2y27A:
undetectable		 2jklF-2y27A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 150
GLY A 144
GLY A 143
LEU A 156
ALA A 118
 None
 0.84A 3douA-2y27A:
3.7		 3douA-2y27A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 4 ASP A 235
GLY A 257
LYS A 322
GLU A 321
 ATP  A 508 (-3.3A)
None
None
None
 1.33A 3hznD-2y27A:
undetectable		 3hznD-2y27A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 4 PRO A  51
LEU A  30
ILE A 299
ARG A 300
 None
None
None
PG4  A 507 ( 4.5A)
 1.47A 3w1wA-2y27A:
3.1		 3w1wA-2y27A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 ILE A 159
ILE A 181
LEU A 207
ILE A 173
 None
 0.90A 4dtaB-2y27A:
undetectable		 4dtaB-2y27A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 238
VAL A 247
TYR A 136
GLY A 146
 GOL  A 505 ( 3.4A)
None
None
None
 0.83A 4forA-2y27A:
undetectable		 4forA-2y27A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 238
LEU A 116
TRP A 113
GLY A 213
GLY A 150
 GOL  A 505 ( 3.4A)
None
None
ATP  A 508 ( 3.9A)
None
 1.09A 5d4uA-2y27A:
3.7		 5d4uA-2y27A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A
HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 4 GLU A   8
ARG A 119
ARG A 315
GLU A  11
 None
 1.14A 5odcB-2y27A:
0.4
5odcC-2y27A:
undetectable
5odcG-2y27A:
4.1		 5odcB-2y27A:
22.67
5odcC-2y27A:
15.56
5odcG-2y27A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 137
GLY A 143
ILE A 191
GLY A 162
GLY A 163
 None
 0.96A 5wyqA-2y27A:
undetectable		 5wyqA-2y27A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A  21
THR A 112
ASN A 115
 None
 0.50A 6baaE-2y27A:
undetectable		 6baaE-2y27A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A  21
THR A 112
ASN A 115
 None
 0.50A 6baaF-2y27A:
undetectable		 6baaF-2y27A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A  21
THR A 112
ASN A 115
 None
 0.51A 6baaG-2y27A:
undetectable		 6baaG-2y27A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A  21
THR A 112
ASN A 115
 None
 0.51A 6baaH-2y27A:
undetectable		 6baaH-2y27A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2y27 PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		3 / 3 ILE A 387
THR A 384
PRO A 376
 None
 0.63A 6ncsA-2y27A:
undetectable		 6ncsA-2y27A:
21.25