SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD
(Citrobacter
freundii) 		5 / 12 ILE A 113
ALA A  74
SER A 100
ILE A 157
ASN A 156
 None
 1.02A 1dlsA-2y2cA:
undetectable		 1dlsA-2y2cA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD
(Citrobacter
freundii) 		5 / 12 GLY A 119
ARG A  80
ILE A  78
ALA A 134
GLN A 131
 None
 1.07A 1oltA-2y2cA:
undetectable		 1oltA-2y2cA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD
(Citrobacter
freundii) 		4 / 5 ARG A  12
ASP A  49
ILE A  48
GLU A  83
 None
 1.19A 2xrzA-2y2cA:
undetectable
2xrzB-2y2cA:
undetectable		 2xrzA-2y2cA:
16.84
2xrzB-2y2cA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD
(Citrobacter
freundii) 		3 / 3 ASP A 164
ARG A 161
LYS A 162
 None
 1.04A 3wipG-2y2cA:
undetectable		 3wipG-2y2cA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD
(Citrobacter
freundii) 		5 / 12 ILE A 113
ALA A  74
SER A 100
ILE A 157
ASN A 156
 None
 1.07A 4gh8A-2y2cA:
undetectable		 4gh8A-2y2cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD
(Citrobacter
freundii) 		5 / 12 ILE A 113
ALA A  74
SER A 100
ILE A 157
ASN A 156
 None
 1.07A 4gh8B-2y2cA:
undetectable		 4gh8B-2y2cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD
(Citrobacter
freundii) 		4 / 5 ALA A  94
ARG A  22
HIS A  34
ALA A  97
 None
 1.44A 5a06C-2y2cA:
undetectable
5a06D-2y2cA:
undetectable		 5a06C-2y2cA:
16.81
5a06D-2y2cA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD
(Citrobacter
freundii) 		4 / 6 ALA A 134
THR A 137
VAL A 136
VAL A  33
 None
 1.07A 5eckD-2y2cA:
undetectable		 5eckD-2y2cA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD
(Citrobacter
freundii) 		3 / 3 THR A 126
ASP A 127
ALA A 128
 None
 0.07A 5g5gB-2y2cA:
undetectable		 5g5gB-2y2cA:
22.15