SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 ALA A 515
LEU A 482
ALA A 483
PHE A 564
LEU A 480
 None
 1.27A 1g5yB-2y2wA:
undetectable		 1g5yB-2y2wA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 8 SER A 299
ALA A 298
ALA A 297
THR A 294
 None
 0.69A 1gtnI-2y2wA:
undetectable
1gtnJ-2y2wA:
undetectable		 1gtnI-2y2wA:
9.33
1gtnJ-2y2wA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 7 TYR A 380
ASN A 412
GLY A  77
TRP A 155
 None
 1.20A 1mxgA-2y2wA:
5.7		 1mxgA-2y2wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 9 LEU A 554
ALA A 552
LEU A 494
GLU A 436
ALA A 483
 None
 1.30A 1sn0A-2y2wA:
undetectable
1sn0C-2y2wA:
undetectable		 1sn0A-2y2wA:
12.72
1sn0C-2y2wA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
LEU A 410
GLY A 160
ALA A 159
SER A 156
 None
 1.06A 2aylA-2y2wA:
undetectable		 2aylA-2y2wA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
LEU A 410
GLY A 160
ALA A 159
SER A 156
 None
 1.07A 2aylB-2y2wA:
undetectable		 2aylB-2y2wA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 11 ARG A  73
ALA A 419
ILE A  79
ILE A 417
ALA A 415
 None
 1.16A 2qhfA-2y2wA:
undetectable		 2qhfA-2y2wA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 6 GLY A 126
TYR A 183
GLY A 124
ASN A 199
 None
 0.95A 3e9rA-2y2wA:
undetectable		 3e9rA-2y2wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		3 / 3 TYR A 110
TYR A  76
GLY A 148
 None
 0.65A 3eteB-2y2wA:
undetectable
3eteD-2y2wA:
undetectable
3eteF-2y2wA:
undetectable		 3eteB-2y2wA:
23.04
3eteD-2y2wA:
23.04
3eteF-2y2wA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
ALA A 438
GLY A 160
ALA A 159
SER A 156
 None
 0.95A 3ln1A-2y2wA:
undetectable		 3ln1A-2y2wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
ALA A 438
GLY A 160
ALA A 159
SER A 156
 None
 0.95A 3ln1B-2y2wA:
undetectable		 3ln1B-2y2wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
ALA A 438
GLY A 160
ALA A 159
SER A 156
 None
 0.94A 3ln1C-2y2wA:
undetectable		 3ln1C-2y2wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
LEU A 410
GLY A 160
ALA A 159
SER A 156
 None
 1.08A 3nt1A-2y2wA:
undetectable		 3nt1A-2y2wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
LEU A 410
GLY A 160
ALA A 159
SER A 156
 None
 1.08A 3nt1B-2y2wA:
undetectable		 3nt1B-2y2wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		3 / 3 TYR A  80
ASP A  88
ASP A  95
 None
 0.90A 3ou7B-2y2wA:
undetectable		 3ou7B-2y2wA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 6 ALA A 515
ILE A 542
LEU A 540
GLU A 436
GLU A 563
 None
 1.48A 3r9sA-2y2wA:
undetectable		 3r9sA-2y2wA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
LEU A 410
GLY A 160
ALA A 159
SER A 156
 None
 1.03A 3rr3A-2y2wA:
undetectable		 3rr3A-2y2wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
LEU A 410
GLY A 160
ALA A 159
SER A 156
 None
 1.03A 3rr3B-2y2wA:
undetectable		 3rr3B-2y2wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
LEU A 410
GLY A 160
ALA A 159
SER A 156
 None
 1.03A 3rr3C-2y2wA:
undetectable		 3rr3C-2y2wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A 108
LEU A 410
GLY A 160
ALA A 159
SER A 156
 None
 1.03A 3rr3D-2y2wA:
undetectable		 3rr3D-2y2wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		3 / 3 TYR A 110
LEU A  63
ARG A 109
 None
 0.59A 3sufB-2y2wA:
undetectable		 3sufB-2y2wA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 11 VAL A 317
ALA A 321
LEU A 336
LEU A 271
GLY A 254
 None
 1.16A 3zosA-2y2wA:
2.0
3zosB-2y2wA:
undetectable		 3zosA-2y2wA:
19.61
3zosB-2y2wA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 6 TYR A  80
VAL A  75
TYR A  76
HIS A  70
 None
 1.38A 4jtrB-2y2wA:
9.6		 4jtrB-2y2wA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		3 / 3 ARG A 134
GLU A 143
PHE A 115
 None
 1.01A 4kszA-2y2wA:
undetectable		 4kszA-2y2wA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 VAL A  96
VAL A 108
LEU A 410
ALA A 159
SER A 156
 None
 1.07A 4m11C-2y2wA:
undetectable		 4m11C-2y2wA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 11 ILE A 542
LEU A 554
SER A  46
ILE A  47
LEU A 481
 None
 1.16A 4qleB-2y2wA:
undetectable		 4qleB-2y2wA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 PRO A 448
ALA A 447
VAL A  56
LEU A  63
LEU A 498
 None
 1.20A 5hv1A-2y2wA:
3.4		 5hv1A-2y2wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		6 / 12 GLY A 104
GLY A  78
VAL A  96
ILE A  79
PHE A 152
GLY A  65
 None
 1.20A 5koxA-2y2wA:
undetectable		 5koxA-2y2wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 10 PRO A 227
PHE A 263
ALA A 285
PHE A 313
VAL A 317
 None
 1.27A 5m0oA-2y2wA:
undetectable		 5m0oA-2y2wA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 6 ARG A  62
PRO A  61
THR A 106
GLU A 162
 None
 1.08A 5ny7A-2y2wA:
undetectable		 5ny7A-2y2wA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 6 ARG A  62
ARG A 403
ALA A 405
PHE A 280
 None
 1.23A 5odqA-2y2wA:
undetectable		 5odqA-2y2wA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 ILE A 417
ALA A 425
ALA A 419
ILE A  79
LEU A  99
 None
 1.11A 6a5zD-2y2wA:
undetectable		 6a5zD-2y2wA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 7 ALA A 382
THR A 381
TYR A 380
VAL A 386
 None
 0.85A 6cduA-2y2wA:
undetectable
6cduE-2y2wA:
undetectable		 6cduA-2y2wA:
19.38
6cduE-2y2wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 8 VAL A 386
ALA A 382
THR A 381
TYR A 380
 None
 0.87A 6cduD-2y2wA:
undetectable
6cduE-2y2wA:
undetectable		 6cduD-2y2wA:
19.38
6cduE-2y2wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 7 VAL A 386
ALA A 382
THR A 381
TYR A 380
 None
 0.86A 6cduH-2y2wA:
undetectable
6cduI-2y2wA:
undetectable		 6cduH-2y2wA:
19.38
6cduI-2y2wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		4 / 6 ILE A 393
LEU A 391
VAL A 484
SER A 307
 None
 1.27A 6f6jA-2y2wA:
undetectable		 6f6jA-2y2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 2y2w ARABINOFURANOSIDASE
(Bifidobacterium
longum) 		5 / 12 ASP A 217
GLU A 215
ASP A 339
LEU A 395
ILE A 314
 None
 1.34A 6fzbB-2y2wA:
undetectable		 6fzbB-2y2wA:
8.42