SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y30'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2y30 PUTATIVE REPRESSOR
SIMREG2
(Streptomyces
antibioticus) 		5 / 10 GLU A 152
ILE A 157
GLY A 158
LEU A 230
ILE A 237
 None
 1.42A 3adsA-2y30A:
undetectable		 3adsA-2y30A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2y30 PUTATIVE REPRESSOR
SIMREG2
(Streptomyces
antibioticus) 		4 / 8 ILE A 237
LEU A 241
VAL A 145
GLY A 144
 None
 0.89A 3w1wA-2y30A:
undetectable		 3w1wA-2y30A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2y30 PUTATIVE REPRESSOR
SIMREG2
(Streptomyces
antibioticus) 		3 / 3 GLU A  85
ARG A 113
HIS A 114
 None
 0.73A 4kf9A-2y30A:
undetectable		 4kf9A-2y30A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2y30 PUTATIVE REPRESSOR
SIMREG2
(Streptomyces
antibioticus) 		5 / 12 LEU A 117
VAL A  79
LEU A 133
ILE A  83
GLU A 165
 None
 0.89A 4ltwA-2y30A:
2.0		 4ltwA-2y30A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2y30 PUTATIVE REPRESSOR
SIMREG2
(Streptomyces
antibioticus) 		4 / 6 LEU A 110
ASP A  80
VAL A  45
ALA A  40
 None
None
CL  A1247 (-4.7A)
None
 0.89A 4nkxA-2y30A:
undetectable		 4nkxA-2y30A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2y30 PUTATIVE REPRESSOR
SIMREG2
(Streptomyces
antibioticus) 		5 / 12 GLN A 136
LEU A  88
LEU A 110
GLY A  84
ASP A  80
 None
 1.14A 4qckA-2y30A:
undetectable		 4qckA-2y30A:
21.21