SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 8 TYR A 785
GLY A 789
LEU A 645
PHE A 739
 None
 0.87A 1gsfC-2y35A:
undetectable		 1gsfC-2y35A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 12 LEU A 251
LEU A  17
ILE A 210
VAL A 658
ARG A 742
 None
 1.24A 1hrkB-2y35A:
3.1		 1hrkB-2y35A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 7 VAL A 956
ILE A 957
HIS A 997
LEU A 916
 None
 0.98A 1j96B-2y35A:
undetectable		 1j96B-2y35A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2y35 LD22664P
(Drosophila
melanogaster) 		3 / 3 PRO A 427
ASP A 429
ASP A 471
 None
 0.71A 1sqfA-2y35A:
2.1		 1sqfA-2y35A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 8 HIS A 699
GLU A  19
HIS A 247
ALA A  21
 None
 0.84A 2bnnA-2y35A:
undetectable
2bnnB-2y35A:
undetectable		 2bnnA-2y35A:
10.45
2bnnB-2y35A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 8 TYR A 307
TRP A 278
TYR A   9
HIS A 297
 None
 1.50A 2ha2A-2y35A:
undetectable		 2ha2A-2y35A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 8 TYR A 307
TRP A 278
TYR A   9
HIS A 297
 None
 1.50A 2ha2B-2y35A:
undetectable		 2ha2B-2y35A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 12 ALA A 942
LEU A 945
LEU A 916
GLY A 887
LEU A 886
 None
 1.01A 2jfaB-2y35A:
undetectable		 2jfaB-2y35A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 5 SER A  84
GLY A 176
HIS A 199
ASP A 182
 None
 1.06A 2oxtB-2y35A:
undetectable		 2oxtB-2y35A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2y35 LD22664P
(Drosophila
melanogaster) 		3 / 3 ASP A  30
ASN A  31
THR A 215
 None
 0.52A 2pymB-2y35A:
undetectable		 2pymB-2y35A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2y35 LD22664P
(Drosophila
melanogaster) 		3 / 3 ASP A  30
ASN A  31
THR A 215
 None
 0.53A 2q63B-2y35A:
undetectable		 2q63B-2y35A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 10 PRO A 173
GLY A  87
LEU A 494
THR A 133
GLY A 135
 None
 1.27A 2vl2A-2y35A:
undetectable
2vl2C-2y35A:
undetectable		 2vl2A-2y35A:
9.71
2vl2C-2y35A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 8 MET A 743
TYR A 254
HIS A 699
GLY A 744
ILE A 745
 None
 1.46A 2zm9A-2y35A:
undetectable		 2zm9A-2y35A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 7 TYR A  14
LEU A 670
CYH A  16
SER A  11
 None
 1.01A 3lm8B-2y35A:
4.1
3lm8D-2y35A:
3.4		 3lm8B-2y35A:
10.88
3lm8D-2y35A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 6 ILE A  39
PRO A  46
GLY A 230
VAL A 238
 None
 0.96A 3n3iA-2y35A:
undetectable		 3n3iA-2y35A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 6 ILE A 817
ILE A1138
GLY A 826
VAL A1052
 None
 0.96A 3n3iA-2y35A:
undetectable		 3n3iA-2y35A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		3 / 3 TYR A 202
ASP A 205
ASP A 288
 None
 0.81A 3ou6B-2y35A:
2.4		 3ou6B-2y35A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 7 HIS A 199
ASN A  31
TYR A  33
LEU A  80
 None
 1.21A 4awuA-2y35A:
undetectable		 4awuA-2y35A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2y35 LD22664P
(Drosophila
melanogaster) 		3 / 3 TYR A 579
MET A 578
ILE A 180
 None
 0.72A 4c8bB-2y35A:
undetectable		 4c8bB-2y35A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 9 TYR A 439
THR A 466
LEU A 293
GLY A 286
VAL A 446
 None
 1.36A 4c9pA-2y35A:
undetectable		 4c9pA-2y35A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2y35 LD22664P
(Drosophila
melanogaster) 		3 / 3 PHE A 243
TYR A  67
TYR A 202
 None
 0.91A 4ffwA-2y35A:
2.3		 4ffwA-2y35A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 8 GLY A 230
ASN A 232
ARG A 235
PRO A  46
 None
 0.83A 4j4vC-2y35A:
undetectable		 4j4vC-2y35A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 8 LEU A 280
LEU A 284
LEU A 296
ILE A 321
 None
 0.85A 4klaA-2y35A:
undetectable		 4klaA-2y35A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 12 LEU A 208
GLU A 177
ASP A  86
LEU A  34
GLY A  38
 None
MG  A2141 (-3.1A)
MG  A2141 (-3.5A)
None
None
 1.41A 4pgfA-2y35A:
2.1		 4pgfA-2y35A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 6 ASN A1046
GLU A 239
TYR A  73
LEU A 159
 None
 1.23A 4twdB-2y35A:
undetectable
4twdC-2y35A:
undetectable		 4twdB-2y35A:
14.46
4twdC-2y35A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 6 ASN A1046
GLU A 239
TYR A  73
LEU A 159
 None
 1.28A 4twdD-2y35A:
undetectable
4twdE-2y35A:
undetectable		 4twdD-2y35A:
14.46
4twdE-2y35A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 7 VAL A 956
ILE A 957
HIS A 997
LEU A 916
 None
 0.87A 4xo7A-2y35A:
undetectable		 4xo7A-2y35A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 11 LEU A 443
TYR A 439
ILE A 321
LEU A 296
LEU A 306
 None
 1.44A 4yvpA-2y35A:
undetectable		 4yvpA-2y35A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 5 TYR A 449
GLY A 176
TYR A 450
GLY A 212
 None
 0.78A 5ayfA-2y35A:
undetectable		 5ayfA-2y35A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 8 PHE A   6
ILE A 298
TYR A   9
GLY A 282
LEU A 255
 None
 1.49A 5esfA-2y35A:
undetectable		 5esfA-2y35A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2y35 LD22664P
(Drosophila
melanogaster) 		6 / 12 GLY A 453
ALA A  92
ILE A 290
ALA A  89
ASP A 182
GLY A 286
 None
 1.35A 5hesA-2y35A:
undetectable		 5hesA-2y35A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2y35 LD22664P
(Drosophila
melanogaster) 		6 / 12 GLY A 453
ALA A  92
ILE A 290
ALA A  89
ASP A 182
GLY A 286
 None
 1.41A 5hesB-2y35A:
undetectable		 5hesB-2y35A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 10 LEU A 250
GLU A  19
LEU A 245
ARG A1095
LEU A 248
 None
 1.48A 5hyrA-2y35A:
undetectable		 5hyrA-2y35A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 6 LYS A  93
ALA A  92
VAL A 446
TYR A 449
 None
 0.98A 5i8fA-2y35A:
undetectable		 5i8fA-2y35A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2y35 LD22664P
(Drosophila
melanogaster) 		3 / 3 CYH A1106
LYS A1107
HIS A1086
 None
 1.26A 5js5A-2y35A:
undetectable		 5js5A-2y35A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2y35 LD22664P
(Drosophila
melanogaster) 		5 / 12 GLU A 852
ASP A1111
GLY A1080
LEU A1136
ALA A1135
 None
 1.28A 5kc4E-2y35A:
undetectable		 5kc4E-2y35A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2y35 LD22664P
(Drosophila
melanogaster) 		4 / 5 ARG A  79
CYH A 163
GLN A  78
PRO A  77
 None
 1.05A 5ki6A-2y35A:
2.3		 5ki6A-2y35A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 2y35 LD22664P
(Drosophila
melanogaster) 		3 / 3 HIS A 292
ASN A 287
ALA A 207
 None
 0.66A 5n4tB-2y35A:
undetectable		 5n4tB-2y35A:
13.71