SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A28_A_STRA1_1 (PROGESTERONE RECEPTOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	LEU A 987 LEU A 828 MET A 830 CYH A 980 PHE A1035	None	1.44A	1a28A-2y3aA: undetectable	1a28A-2y3aA: 15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CMC_A_SAMA105_0 (MET REPRESSOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 10	GLY A 619 GLU A 599 GLU A 602 LEU A 603 PRO A 568	None	1.35A	1cmcA-2y3aA: undetectable 1cmcB-2y3aA: undetectable	1cmcA-2y3aA: 8.80 1cmcB-2y3aA: 8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_RALA600_2 (ESTROGEN RECEPTOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 6	LEU A 634 LEU A 997 LEU A1009 LEU A 820	None	0.90A	1errA-2y3aA: 1.9	1errA-2y3aA: 13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETA_1_T441128_1 (TRANSTHYRETIN)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 5	LEU A 351 GLU A 356 ALA A 392 LEU A 394	None	0.95A	1eta1-2y3aA: 3.0	1eta1-2y3aA: 7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETA_2_T442129_1 (TRANSTHYRETIN)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 5	LEU A 351 GLU A 356 ALA A 392 LEU A 394	None	0.92A	1eta2-2y3aA: 2.7	1eta2-2y3aA: 7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FML_A_RTLA401_0 (RETINOL DEHYDRATASE)	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Mus musculus)	5 / 12	TYR B 680 TYR B 690 LEU B 683 TYR B 649 ILE B 640	None	1.38A	1fmlA-2y3aB: undetectable	1fmlA-2y3aB: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KXH_A_ACRA598_2 (ALPHA-AMYLASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	TRP A 592 TYR A 616 LEU A 603	None	1.00A	1kxhA-2y3aA: undetectable	1kxhA-2y3aA: 17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1M4I_A_KANA500_1 (AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERA SE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 8	ASP A 827 ASP A 818 GLY A 901 THR A 924	None	0.79A	1m4iA-2y3aA: undetectable	1m4iA-2y3aA: 10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1M4I_A_KANA500_1 (AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERA SE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 8	ASP A 913 ASP A 807 THR A 810 ASP A 931	None GD9 A2058 (-3.7A) None GD9 A2058 (-3.2A)	0.80A	1m4iA-2y3aA: undetectable	1m4iA-2y3aA: 10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJ2_A_SAMA2200_0 (PROTEIN (METHIONINE REPRESSOR))	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	GLY A 619 GLU A 599 GLU A 602 LEU A 603 PRO A 568	None	1.31A	1mj2A-2y3aA: undetectable 1mj2B-2y3aA: undetectable	1mj2A-2y3aA: 7.52 1mj2B-2y3aA: 7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_A_SAMA200_0 (METHIONINE REPRESSOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 11	GLU A 599 GLU A 602 LEU A 603 PRO A 568 GLY A 619	None	1.32A	1mjqA-2y3aA: undetectable 1mjqB-2y3aA: undetectable	1mjqA-2y3aA: 7.52 1mjqB-2y3aA: 7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_B_SAMB200_0 (METHIONINE REPRESSOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 11	GLY A 619 GLU A 599 GLU A 602 LEU A 603 PRO A 568	None	1.31A	1mjqA-2y3aA: undetectable 1mjqB-2y3aA: undetectable	1mjqA-2y3aA: 7.52 1mjqB-2y3aA: 7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_C_SAMC199_0 (METHIONINE REPRESSOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 10	GLU A 599 GLU A 602 LEU A 603 PRO A 568 GLY A 619	None	1.33A	1mjqC-2y3aA: undetectable 1mjqD-2y3aA: undetectable	1mjqC-2y3aA: 7.52 1mjqD-2y3aA: 7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_G_SAMG199_0 (METHIONINE REPRESSOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 10	GLU A 599 GLU A 602 LEU A 603 PRO A 568 GLY A 619	None	1.31A	1mjqG-2y3aA: undetectable 1mjqH-2y3aA: undetectable	1mjqG-2y3aA: 7.52 1mjqH-2y3aA: 7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_H_SAMH200_0 (METHIONINE REPRESSOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 10	GLY A 619 GLU A 599 GLU A 602 LEU A 603 PRO A 568	None	1.31A	1mjqG-2y3aA: undetectable 1mjqH-2y3aA: undetectable	1mjqG-2y3aA: 7.52 1mjqH-2y3aA: 7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_I_SAMI199_0 (METHIONINE REPRESSOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 11	GLU A 599 GLU A 602 LEU A 603 PRO A 568 GLY A 619	None	1.32A	1mjqI-2y3aA: undetectable 1mjqJ-2y3aA: undetectable	1mjqI-2y3aA: 7.52 1mjqJ-2y3aA: 7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MRL_A_DOLA300_1 (STREPTOGRAMIN A ACETYLTRANSFERASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 11	ILE A 574 PRO A 389 LEU A 358 TYR A 642 ASP A 605	None	1.19A	1mrlA-2y3aA: undetectable 1mrlB-2y3aA: undetectable	1mrlA-2y3aA: 10.35 1mrlB-2y3aA: 10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OLT_A_SAMA501_0 (OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE)	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Mus musculus)	5 / 12	THR B 703 ASP B 656 GLY B 657 ASP B 658 ALA B 626	None	1.10A	1oltA-2y3aB: undetectable	1oltA-2y3aB: 22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RLB_E_REAE176_1 (RETINOL BINDING PROTEIN)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 10	ALA A 983 ALA A 905 LEU A 927 GLN A 926 ASP A 827	None	1.19A	1rlbE-2y3aA: undetectable	1rlbE-2y3aA: 10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TLM_A_MILA128_1 (TRANSTHYRETIN)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	LEU A 567 LEU A 570 SER A 573	None	0.68A	1tlmA-2y3aA: undetectable	1tlmA-2y3aA: 7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VM1_A_TAZA504_1 (BETA-LACTAMASE SHV-1)	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	ASP B 455 TYR B 458 GLU A 462	None	0.57A	1vm1A-2y3aB: undetectable	1vm1A-2y3aB: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_B_DVAB8_0 (GRAMICIDIN D)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	VAL A 435 VAL A 473 TRP A 456	None	0.95A	1w5uA-2y3aA: undetectable 1w5uB-2y3aA: undetectable	1w5uA-2y3aA: 1.45 1w5uB-2y3aA: 1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_E_TFPE212_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 7	PHE A1039 LEU A 927 PHE A 952 SER A1046	None	1.15A	1wrlE-2y3aA: undetectable	1wrlE-2y3aA: 7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WSV_A_THHA3001_0 (AMINOMETHYLTRANSFERA SE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	THR A 330 LEU A 331 ILE A 487 VAL A 451 PHE A 381	None	1.18A	1wsvA-2y3aA: undetectable	1wsvA-2y3aA: 16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WSV_B_THHB4001_0 (AMINOMETHYLTRANSFERA SE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	THR A 330 LEU A 331 ILE A 487 VAL A 451 PHE A 381	None	1.16A	1wsvB-2y3aA: undetectable	1wsvB-2y3aA: 16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDK_B_9CRB600_2 (RETINOIC ACID RECEPTOR, BETA)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	LEU A 242 PHE A 275 ARG A 662	None	0.79A	1xdkB-2y3aA: undetectable	1xdkB-2y3aA: 14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDK_F_9CRF1600_2 (RETINOIC ACID RECEPTOR, BETA)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	LEU A 242 PHE A 275 ARG A 662	None	0.79A	1xdkF-2y3aA: undetectable	1xdkF-2y3aA: 14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XVA_B_ACTB294_0 (GLYCINE N-METHYLTRANSFERASE)	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Mus musculus)	4 / 6	ALA B 544 TYR B 461 ILE B 550 LEU B 468	None	0.97A	1xvaA-2y3aB: undetectable 1xvaB-2y3aB: undetectable	1xvaA-2y3aB: 24.70 1xvaB-2y3aB: 24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3A_A_TEPA1436_1 (CHITINASE)	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	ASP A 27 PHE B 485 ARG B 525	None	0.77A	2a3aA-2y3aA: undetectable	2a3aA-2y3aA: 17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOU_A_CQAA403_0 (HISTAMINE N-METHYLTRANSFERASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 8	ASP A 818 TRP A 821 LYS A 822 GLY A 825	None	0.86A	2aouA-2y3aA: undetectable	2aouA-2y3aA: 14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXE_B_1FLB2002_1 (SERUM ALBUMIN)	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 11	PHE A 74 ALA A 75 GLU B 487 LEU A 103 VAL A 102	None	1.05A	2bxeB-2y3aA: undetectable	2bxeB-2y3aA: 18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CIZ_A_ACTA1321_0 (CHLOROPEROXIDASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 5	LEU A 828 PHE A 976 VAL A 904 ALA A 983	None	1.16A	2cizA-2y3aA: undetectable	2cizA-2y3aA: 15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_C_DVAC8_0 (GRAMICIDIN D)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	VAL A 473 TRP A 456 VAL A 435	None	0.98A	2izqC-2y3aA: undetectable 2izqD-2y3aA: undetectable	2izqC-2y3aA: 1.45 2izqD-2y3aA: 1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_A_SAMA302_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Mus musculus; Mus musculus)	3 / 3	THR B 462 ASP A 803 SER A 842	None	0.66A	2nxeA-2y3aB: undetectable	2nxeA-2y3aB: 22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_B_SAMB303_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Mus musculus; Mus musculus)	3 / 3	THR B 462 ASP A 803 SER A 842	None	0.72A	2nxeB-2y3aB: undetectable	2nxeB-2y3aB: 22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XZ5_A_ACHA1211_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Mus musculus)	4 / 7	SER B 652 CYH B 651 GLN B 645 ILE B 664	None	1.22A	2xz5A-2y3aB: undetectable 2xz5B-2y3aB: undetectable	2xz5A-2y3aB: 20.13 2xz5B-2y3aB: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZM9_A_ACAA502_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 8	ALA A 735 TYR A 772 HIS A 737 ILE A 720	None	0.84A	2zm9A-2y3aA: undetectable	2zm9A-2y3aA: 15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ERD_A_DESA600_1 (ESTROGEN RECEPTOR ALPHA)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	LEU A1009 LEU A1002 LEU A1000 MET A 813 LEU A 936	None	1.24A	3erdA-2y3aA: undetectable	3erdA-2y3aA: 13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWX_B_EPAB3_1 (PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA)))	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Mus musculus)	5 / 12	THR B 667 THR B 669 HIS B 698 LEU B 686 TYR B 690	None	1.32A	3gwxB-2y3aB: undetectable	3gwxB-2y3aB: 23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDI_A_SAMA601_0 (METHYLTRANSFERASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	ILE A 962 PHE A 973 ALA A 900 THR A 896 ILE A 892	None	1.20A	3ndiA-2y3aA: undetectable	3ndiA-2y3aA: 18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O7W_A_SAMA801_1 (LEUCINE CARBOXYL METHYLTRANSFERASE 1)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	LYS A 185 ARG A 890 ASP A 818	None	1.42A	3o7wA-2y3aA: undetectable	3o7wA-2y3aA: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OHT_B_1N1B1000_2 (P38A)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	GLU A1029 LEU A1032 LEU A1022	None	0.77A	3ohtB-2y3aA: 2.5	3ohtB-2y3aA: 16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QL6_A_NIMA614_1 (LACTOPEROXIDASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 7	GLN A 631 GLU A 249 PHE A 667 PRO A 758	None	1.07A	3ql6A-2y3aA: undetectable	3ql6A-2y3aA: 20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3V_A_TOPA193_1 (DIHYDROFOLATE REDUCTASE)	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 5	ASP A1040 LEU B 679 ILE A 959 PHE A 973	None	1.14A	3s3vA-2y3aA: undetectable	3s3vA-2y3aA: 11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_D_9PLD1_1 (CYTOCHROME P450 2A13)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 8	PHE A1039 PHE A1035 PHE A 952 ALA A 900 THR A 896	None	1.41A	3t3sD-2y3aA: undetectable	3t3sD-2y3aA: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3THR_A_C2FA1100_1 (GLYCINE N-METHYLTRANSFERASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	LEU A 740 HIS A 737 MET A 736	None	0.95A	3thrD-2y3aA: undetectable	3thrD-2y3aA: 14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UG8_A_IMNA2001_2 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	TYR A 608 GLU A 615 TYR A 612	None	0.96A	3ug8A-2y3aA: undetectable	3ug8A-2y3aA: 14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V5W_A_8PRA701_2 (G-PROTEIN COUPLED RECEPTOR KINASE 2)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	LEU A 103 MET A 73 ASP A 88	None	0.87A	3v5wA-2y3aA: undetectable	3v5wA-2y3aA: 21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 8	VAL A 921 TYR A 902 CYH A 899 ILE A 919	None	1.31A	4bqtC-2y3aA: undetectable 4bqtD-2y3aA: undetectable	4bqtC-2y3aA: 12.55 4bqtD-2y3aA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D39_B_ACTB860_0 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 6	GLY A 686 ILE A 688 GLN A 684 VAL A 139	None	1.09A	4d39B-2y3aA: undetectable	4d39B-2y3aA: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IJI_F_BEZF501_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN YIBF)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 8	ASN A 723 ALA A 735 LEU A 719 TYR A 745	None	1.16A	4ijiF-2y3aA: undetectable	4ijiF-2y3aA: 10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K87_A_ADNA602_1 (PROLINE--TRNA LIGASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 8	ARG A 270 GLN A 926 GLY A 925 THR A 924	None	0.91A	4k87A-2y3aA: undetectable	4k87A-2y3aA: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_A_ACTA803_0 (NITRIC OXIDE SYNTHASE, BRAIN)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 6	GLY A 686 ILE A 688 GLN A 684 VAL A 139	None	1.11A	4kcnA-2y3aA: undetectable	4kcnA-2y3aA: 17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_A_MTLA804_0 (NITRIC OXIDE SYNTHASE, BRAIN)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 6	ARG A 805 ASP A 840 ASP A 803 ARG A 841	None	1.29A	4kcnA-2y3aA: undetectable	4kcnA-2y3aA: 17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_B_MTLB805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 6	ARG A 805 ASP A 840 ASP A 803 ARG A 841	None	1.30A	4kcnB-2y3aA: undetectable	4kcnB-2y3aA: 17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R38_C_RBFC201_2 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 9	ASN A 607 LEU A1000 VAL A1012 LEU A 541 ILE A1015	None	1.28A	4r38C-2y3aA: 1.4	4r38C-2y3aA: 9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5Q_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 6	ARG A 694 ILE A 154 ILE A 120 ASP A 117	None	0.88A	4w5qA-2y3aA: undetectable	4w5qA-2y3aA: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5T_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 6	ARG A 694 ILE A 154 ILE A 120 ASP A 117	None	0.97A	4w5tA-2y3aA: undetectable	4w5tA-2y3aA: 20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	ILE A 845 VAL A 848 THR A 853 MET A 920 ILE A 930	GD9 A2058 (-3.8A) GD9 A2058 (-3.8A) GD9 A2058 ( 4.8A) GD9 A2058 (-3.6A) GD9 A2058 (-4.2A)	1.01A	4xe0A-2y3aA: 38.7	4xe0A-2y3aA: 51.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	6 / 12	MET A 773 PRO A 779 TYR A 833 ASP A 856 MET A 920 ILE A 930	GD9 A2058 (-4.3A) None GD9 A2058 (-3.8A) GD9 A2058 ( 4.6A) GD9 A2058 (-3.6A) GD9 A2058 (-4.2A)	1.46A	4xe0A-2y3aA: 38.7	4xe0A-2y3aA: 51.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	6 / 12	MET A 773 PRO A 779 TYR A 833 VAL A 848 MET A 920 ILE A 930	GD9 A2058 (-4.3A) None GD9 A2058 (-3.8A) GD9 A2058 (-3.8A) GD9 A2058 (-3.6A) GD9 A2058 (-4.2A)	0.99A	4xe0A-2y3aA: 38.7	4xe0A-2y3aA: 51.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	7 / 12	PRO A 779 ILE A 797 TYR A 833 ASP A 856 THR A 853 MET A 920 ILE A 930	None None GD9 A2058 (-3.8A) GD9 A2058 ( 4.6A) GD9 A2058 ( 4.8A) GD9 A2058 (-3.6A) GD9 A2058 (-4.2A)	1.25A	4xe0A-2y3aA: 38.7	4xe0A-2y3aA: 51.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	7 / 12	PRO A 779 ILE A 797 TYR A 833 VAL A 848 THR A 853 MET A 920 ILE A 930	None None GD9 A2058 (-3.8A) GD9 A2058 (-3.8A) GD9 A2058 ( 4.8A) GD9 A2058 (-3.6A) GD9 A2058 (-4.2A)	0.66A	4xe0A-2y3aA: 38.7	4xe0A-2y3aA: 51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XO7_A_ASDA402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 7	TYR A 608 VAL A1012 ILE A1015 LEU A1000	None	1.01A	4xo7A-2y3aA: undetectable	4xo7A-2y3aA: 14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4G_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 7	ARG A 694 ILE A 154 ILE A 120 ASP A 117	None	0.96A	4z4gA-2y3aA: undetectable	4z4gA-2y3aA: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CSW_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	PHE A 74 ILE A 49 ASP A 95	None	0.62A	5cswA-2y3aA: 2.6	5cswA-2y3aA: 14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CSW_B_P06B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	PHE A 74 ILE A 49 ASP A 95	None	0.66A	5cswB-2y3aA: 2.9	5cswB-2y3aA: 14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HBS_A_RTLA201_1 (RETINOL-BINDING PROTEIN 1)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 8	LEU A 633 LEU A 640 TYR A 692 TRP A 670	None	1.17A	5hbsA-2y3aA: undetectable	5hbsA-2y3aA: 8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEP_A_VDYA201_2 (CDL2.3B)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 9	PRO A 597 MET A 624 VAL A 639 LEU A1000 LEU A 567	None	1.50A	5iepA-2y3aA: undetectable	5iepA-2y3aA: 8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWW_A_ACAA18_2 (SCRFP-TAG,GP41)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	LYS A 922 TRP A 878 SER A 851	None None GD9 A2058 ( 4.5A)	1.23A	5nwwA-2y3aA: undetectable	5nwwA-2y3aA: 3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UHB_C_RFPC1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	PHE A 645 ASP A 647 LEU A 636	None	0.79A	5uhbC-2y3aA: 2.1	5uhbC-2y3aA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UHC_C_RFPC1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	PHE A 645 ASP A 647 LEU A 636	None	0.71A	5uhcC-2y3aA: undetectable	5uhcC-2y3aA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCE_A_RITA602_2 (CYTOCHROME P450 3A4)	2y3a	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 6	ARG A1044 PHE B 671 PHE B 673 ILE B 640	None	1.06A	5vceA-2y3aA: undetectable	5vceA-2y3aA: 18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_A_RITA602_2 (CYTOCHROME P450 3A5)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	ARG A 147 PHE A 669 LEU A 655	None	0.85A	5veuA-2y3aA: undetectable	5veuA-2y3aA: 19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZV2_A_LEVA801_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	3 / 3	LYS A 776 LEU A 804 ASP A 931	None None GD9 A2058 (-3.2A)	0.89A	5zv2A-2y3aA: 2.4	5zv2A-2y3aA: 5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_2 (PROTEIN CYP51)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 7	VAL A 950 PRO A 832 LEU A 831 LEU A 814	None	1.14A	6aycA-2y3aA: undetectable	6aycA-2y3aA: 5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CBD_A_TRPA903_0 (PROTEIN ARGONAUTE-2)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 6	ARG A 694 ILE A 154 ILE A 120 ASP A 117	None	0.94A	6cbdA-2y3aA: undetectable	6cbdA-2y3aA: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWD_A_GLYA717_0 (DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 5	SER A 542 ARG A 538 ASP A 539 LYS A1019	None	1.40A	6dwdA-2y3aA: undetectable	6dwdA-2y3aA: 18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EKZ_A_SNPA414_0 (AROMATIC PEROXYGENASE)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	4 / 5	PHE A 645 VAL A 618 PRO A 609 MET A 391	None	1.30A	6ekzA-2y3aA: undetectable	6ekzA-2y3aA: 6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F3M_A_ADNA502_1 (-)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	ASP A 660 HIS A 168 LEU A 157 GLY A 698 HIS A 699	None	1.28A	6f3mA-2y3aA: undetectable	6f3mA-2y3aA: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F3M_C_ADNC502_1 (-)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	ASP A 660 HIS A 168 LEU A 157 GLY A 698 HIS A 699	None	1.29A	6f3mC-2y3aA: undetectable	6f3mC-2y3aA: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IBL_A_H98A501_0 (THIOREDOXIN 1,BETA-1 ADRENERGIC RECEPTOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	THR A 475 VAL A 473 PHE A 442 PHE A 645 VAL A 139	None	1.44A	6iblA-2y3aA: undetectable	6iblA-2y3aA: 17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IBL_B_H98B501_0 (THIOREDOXIN 1,BETA-1 ADRENERGIC RECEPTOR)	2y3a	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (Mus musculus)	5 / 12	THR A 475 VAL A 473 PHE A 442 PHE A 645 VAL A 139	None	1.44A	6iblB-2y3aA: undetectable	6iblB-2y3aA: 17.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A28_A_STRA1_1","PROGESTERONE RECEPTOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"LEU A 987;LEU A 828;MET A 830;CYH A 980;PHE A1035","None","1.44A","1a28A-2y3aA:undetectable","1a28A-2y3aA:15.81"],["1CMC_A_SAMA105_0","MET REPRESSOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"GLY A 619;GLU A 599;GLU A 602;LEU A 603;PRO A 568","None","1.35A","1cmcA-2y3aA:undetectable;1cmcB-2y3aA:undetectable","1cmcA-2y3aA:8.80;1cmcB-2y3aA:8.80"],["1ERR_A_RALA600_2","ESTROGEN RECEPTOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"LEU A 634;LEU A 997;LEU A1009;LEU A 820","None","0.90A","1errA-2y3aA:1.9","1errA-2y3aA:13.44"],["1ETA_1_T441128_1","TRANSTHYRETIN","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"LEU A 351;GLU A 356;ALA A 392;LEU A 394","None","0.95A","1eta1-2y3aA:3.0","1eta1-2y3aA:7.07"],["1ETA_2_T442129_1","TRANSTHYRETIN","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"LEU A 351;GLU A 356;ALA A 392;LEU A 394","None","0.92A","1eta2-2y3aA:2.7","1eta2-2y3aA:7.07"],["1FML_A_RTLA401_0","RETINOL DEHYDRATASE","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Mus musculus",5,"TYR B 680;TYR B 690;LEU B 683;TYR B 649;ILE B 640","None","1.38A","1fmlA-2y3aB:undetectable","1fmlA-2y3aB:23.26"],["1KXH_A_ACRA598_2","ALPHA-AMYLASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"TRP A 592;TYR A 616;LEU A 603","None","1.00A","1kxhA-2y3aA:undetectable","1kxhA-2y3aA:17.61"],["1M4I_A_KANA500_1","AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ASP A 827;ASP A 818;GLY A 901;THR A 924","None","0.79A","1m4iA-2y3aA:undetectable","1m4iA-2y3aA:10.21"],["1M4I_A_KANA500_1","AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ASP A 913;ASP A 807;THR A 810;ASP A 931","None;GD9 A2058 (-3.7A);None;GD9 A2058 (-3.2A)","0.80A","1m4iA-2y3aA:undetectable","1m4iA-2y3aA:10.21"],["1MJ2_A_SAMA2200_0","PROTEIN (METHIONINE REPRESSOR)","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"GLY A 619;GLU A 599;GLU A 602;LEU A 603;PRO A 568","None","1.31A","1mj2A-2y3aA:undetectable;1mj2B-2y3aA:undetectable","1mj2A-2y3aA:7.52;1mj2B-2y3aA:7.52"],["1MJQ_A_SAMA200_0","METHIONINE REPRESSOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"GLU A 599;GLU A 602;LEU A 603;PRO A 568;GLY A 619","None","1.32A","1mjqA-2y3aA:undetectable;1mjqB-2y3aA:undetectable","1mjqA-2y3aA:7.52;1mjqB-2y3aA:7.52"],["1MJQ_B_SAMB200_0","METHIONINE REPRESSOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"GLY A 619;GLU A 599;GLU A 602;LEU A 603;PRO A 568","None","1.31A","1mjqA-2y3aA:undetectable;1mjqB-2y3aA:undetectable","1mjqA-2y3aA:7.52;1mjqB-2y3aA:7.52"],["1MJQ_C_SAMC199_0","METHIONINE REPRESSOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"GLU A 599;GLU A 602;LEU A 603;PRO A 568;GLY A 619","None","1.33A","1mjqC-2y3aA:undetectable;1mjqD-2y3aA:undetectable","1mjqC-2y3aA:7.52;1mjqD-2y3aA:7.52"],["1MJQ_G_SAMG199_0","METHIONINE REPRESSOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"GLU A 599;GLU A 602;LEU A 603;PRO A 568;GLY A 619","None","1.31A","1mjqG-2y3aA:undetectable;1mjqH-2y3aA:undetectable","1mjqG-2y3aA:7.52;1mjqH-2y3aA:7.52"],["1MJQ_H_SAMH200_0","METHIONINE REPRESSOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"GLY A 619;GLU A 599;GLU A 602;LEU A 603;PRO A 568","None","1.31A","1mjqG-2y3aA:undetectable;1mjqH-2y3aA:undetectable","1mjqG-2y3aA:7.52;1mjqH-2y3aA:7.52"],["1MJQ_I_SAMI199_0","METHIONINE REPRESSOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"GLU A 599;GLU A 602;LEU A 603;PRO A 568;GLY A 619","None","1.32A","1mjqI-2y3aA:undetectable;1mjqJ-2y3aA:undetectable","1mjqI-2y3aA:7.52;1mjqJ-2y3aA:7.52"],["1MRL_A_DOLA300_1","STREPTOGRAMIN A ACETYLTRANSFERASE;STREPTOGRAMIN A ACETYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"ILE A 574;PRO A 389;LEU A 358;TYR A 642;ASP A 605","None","1.19A","1mrlA-2y3aA:undetectable;1mrlB-2y3aA:undetectable","1mrlA-2y3aA:10.35;1mrlB-2y3aA:10.35"],["1OLT_A_SAMA501_0","OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Mus musculus",5,"THR B 703;ASP B 656;GLY B 657;ASP B 658;ALA B 626","None","1.10A","1oltA-2y3aB:undetectable","1oltA-2y3aB:22.13"],["1RLB_E_REAE176_1","RETINOL BINDING PROTEIN","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"ALA A 983;ALA A 905;LEU A 927;GLN A 926;ASP A 827","None","1.19A","1rlbE-2y3aA:undetectable","1rlbE-2y3aA:10.39"],["1TLM_A_MILA128_1","TRANSTHYRETIN","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"LEU A 567;LEU A 570;SER A 573","None","0.68A","1tlmA-2y3aA:undetectable","1tlmA-2y3aA:7.44"],["1VM1_A_TAZA504_1","BETA-LACTAMASE SHV-1","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA;PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"ASP B 455;TYR B 458;GLU A 462","None","0.57A","1vm1A-2y3aB:undetectable","1vm1A-2y3aB:22.46"],["1W5U_B_DVAB8_0","GRAMICIDIN D","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"VAL A 435;VAL A 473;TRP A 456","None","0.95A","1w5uA-2y3aA:undetectable;1w5uB-2y3aA:undetectable","1w5uA-2y3aA:1.45;1w5uB-2y3aA:1.45"],["1WRL_E_TFPE212_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"PHE A1039;LEU A 927;PHE A 952;SER A1046","None","1.15A","1wrlE-2y3aA:undetectable","1wrlE-2y3aA:7.70"],["1WSV_A_THHA3001_0","AMINOMETHYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"THR A 330;LEU A 331;ILE A 487;VAL A 451;PHE A 381","None","1.18A","1wsvA-2y3aA:undetectable","1wsvA-2y3aA:16.48"],["1WSV_B_THHB4001_0","AMINOMETHYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"THR A 330;LEU A 331;ILE A 487;VAL A 451;PHE A 381","None","1.16A","1wsvB-2y3aA:undetectable","1wsvB-2y3aA:16.48"],["1XDK_B_9CRB600_2","RETINOIC ACID RECEPTOR, BETA","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"LEU A 242;PHE A 275;ARG A 662","None","0.79A","1xdkB-2y3aA:undetectable","1xdkB-2y3aA:14.82"],["1XDK_F_9CRF1600_2","RETINOIC ACID RECEPTOR, BETA","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"LEU A 242;PHE A 275;ARG A 662","None","0.79A","1xdkF-2y3aA:undetectable","1xdkF-2y3aA:14.82"],["1XVA_B_ACTB294_0","GLYCINE N-METHYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Mus musculus",4,"ALA B 544;TYR B 461;ILE B 550;LEU B 468","None","0.97A","1xvaA-2y3aB:undetectable;1xvaB-2y3aB:undetectable","1xvaA-2y3aB:24.70;1xvaB-2y3aB:24.70"],["2A3A_A_TEPA1436_1","CHITINASE","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA;PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"ASP A  27;PHE B 485;ARG B 525","None","0.77A","2a3aA-2y3aA:undetectable","2a3aA-2y3aA:17.68"],["2AOU_A_CQAA403_0","HISTAMINE N-METHYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ASP A 818;TRP A 821;LYS A 822;GLY A 825","None","0.86A","2aouA-2y3aA:undetectable","2aouA-2y3aA:14.07"],["2BXE_B_1FLB2002_1","SERUM ALBUMIN","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA;PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"PHE A  74;ALA A  75;GLU B 487;LEU A 103;VAL A 102","None","1.05A","2bxeB-2y3aA:undetectable","2bxeB-2y3aA:18.96"],["2CIZ_A_ACTA1321_0","CHLOROPEROXIDASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"LEU A 828;PHE A 976;VAL A 904;ALA A 983","None","1.16A","2cizA-2y3aA:undetectable","2cizA-2y3aA:15.91"],["2IZQ_C_DVAC8_0","GRAMICIDIN D","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"VAL A 473;TRP A 456;VAL A 435","None","0.98A","2izqC-2y3aA:undetectable;2izqD-2y3aA:undetectable","2izqC-2y3aA:1.45;2izqD-2y3aA:1.45"],["2NXE_A_SAMA302_1","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM;PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Mus musculus;Mus musculus",3,"THR B 462;ASP A 803;SER A 842","None","0.66A","2nxeA-2y3aB:undetectable","2nxeA-2y3aB:22.52"],["2NXE_B_SAMB303_1","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM;PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Mus musculus;Mus musculus",3,"THR B 462;ASP A 803;SER A 842","None","0.72A","2nxeB-2y3aB:undetectable","2nxeB-2y3aB:22.52"],["2XZ5_A_ACHA1211_0","SOLUBLE ACETYLCHOLINE RECEPTOR","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Mus musculus",4,"SER B 652;CYH B 651;GLN B 645;ILE B 664","None","1.22A","2xz5A-2y3aB:undetectable;2xz5B-2y3aB:undetectable","2xz5A-2y3aB:20.13;2xz5B-2y3aB:20.13"],["2ZM9_A_ACAA502_1","6-AMINOHEXANOATE-DIMER HYDROLASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ALA A 735;TYR A 772;HIS A 737;ILE A 720","None","0.84A","2zm9A-2y3aA:undetectable","2zm9A-2y3aA:15.53"],["3ERD_A_DESA600_1","ESTROGEN RECEPTOR ALPHA","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"LEU A1009;LEU A1002;LEU A1000;MET A 813;LEU A 936","None","1.24A","3erdA-2y3aA:undetectable","3erdA-2y3aA:13.19"],["3GWX_B_EPAB3_1","PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA))","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Mus musculus",5,"THR B 667;THR B 669;HIS B 698;LEU B 686;TYR B 690","None","1.32A","3gwxB-2y3aB:undetectable","3gwxB-2y3aB:23.01"],["3NDI_A_SAMA601_0","METHYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"ILE A 962;PHE A 973;ALA A 900;THR A 896;ILE A 892","None","1.20A","3ndiA-2y3aA:undetectable","3ndiA-2y3aA:18.09"],["3O7W_A_SAMA801_1","LEUCINE CARBOXYL METHYLTRANSFERASE 1","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"LYS A 185;ARG A 890;ASP A 818","None","1.42A","3o7wA-2y3aA:undetectable","3o7wA-2y3aA:16.34"],["3OHT_B_1N1B1000_2","P38A","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"GLU A1029;LEU A1032;LEU A1022","None","0.77A","3ohtB-2y3aA:2.5","3ohtB-2y3aA:16.85"],["3QL6_A_NIMA614_1","LACTOPEROXIDASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"GLN A 631;GLU A 249;PHE A 667;PRO A 758","None","1.07A","3ql6A-2y3aA:undetectable","3ql6A-2y3aA:20.24"],["3S3V_A_TOPA193_1","DIHYDROFOLATE REDUCTASE","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA;PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ASP A1040;LEU B 679;ILE A 959;PHE A 973","None","1.14A","3s3vA-2y3aA:undetectable","3s3vA-2y3aA:11.00"],["3T3S_D_9PLD1_1","CYTOCHROME P450 2A13","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"PHE A1039;PHE A1035;PHE A 952;ALA A 900;THR A 896","None","1.41A","3t3sD-2y3aA:undetectable","3t3sD-2y3aA:18.59"],["3THR_A_C2FA1100_1","GLYCINE N-METHYLTRANSFERASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"LEU A 740;HIS A 737;MET A 736","None","0.95A","3thrD-2y3aA:undetectable","3thrD-2y3aA:14.59"],["3UG8_A_IMNA2001_2","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"TYR A 608;GLU A 615;TYR A 612","None","0.96A","3ug8A-2y3aA:undetectable","3ug8A-2y3aA:14.57"],["3V5W_A_8PRA701_2","G-PROTEIN COUPLED RECEPTOR KINASE 2","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"LEU A 103;MET A  73;ASP A  88","None","0.87A","3v5wA-2y3aA:undetectable","3v5wA-2y3aA:21.42"],["4BQT_C_C5EC301_0","SOLUBLE ACETYLCHOLINE RECEPTOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"VAL A 921;TYR A 902;CYH A 899;ILE A 919","None","1.31A","4bqtC-2y3aA:undetectable;4bqtD-2y3aA:undetectable","4bqtC-2y3aA:12.55;4bqtD-2y3aA:12.55"],["4D39_B_ACTB860_0","NITRIC OXIDE SYNTHASE, ENDOTHELIAL","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"GLY A 686;ILE A 688;GLN A 684;VAL A 139","None","1.09A","4d39B-2y3aA:undetectable","4d39B-2y3aA:18.15"],["4IJI_F_BEZF501_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN YIBF","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ASN A 723;ALA A 735;LEU A 719;TYR A 745","None","1.16A","4ijiF-2y3aA:undetectable","4ijiF-2y3aA:10.46"],["4K87_A_ADNA602_1","PROLINE--TRNA LIGASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ARG A 270;GLN A 926;GLY A 925;THR A 924","None","0.91A","4k87A-2y3aA:undetectable","4k87A-2y3aA:18.68"],["4KCN_A_ACTA803_0","NITRIC OXIDE SYNTHASE, BRAIN","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"GLY A 686;ILE A 688;GLN A 684;VAL A 139","None","1.11A","4kcnA-2y3aA:undetectable","4kcnA-2y3aA:17.66"],["4KCN_A_MTLA804_0","NITRIC OXIDE SYNTHASE, BRAIN","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ARG A 805;ASP A 840;ASP A 803;ARG A 841","None","1.29A","4kcnA-2y3aA:undetectable","4kcnA-2y3aA:17.66"],["4KCN_B_MTLB805_0","NITRIC OXIDE SYNTHASE, BRAIN","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ARG A 805;ASP A 840;ASP A 803;ARG A 841","None","1.30A","4kcnB-2y3aA:undetectable","4kcnB-2y3aA:17.66"],["4R38_C_RBFC201_2","BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"ASN A 607;LEU A1000;VAL A1012;LEU A 541;ILE A1015","None","1.28A","4r38C-2y3aA:1.4","4r38C-2y3aA:9.32"],["4W5Q_A_IPHA902_0","PROTEIN ARGONAUTE-2","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ARG A 694;ILE A 154;ILE A 120;ASP A 117","None","0.88A","4w5qA-2y3aA:undetectable","4w5qA-2y3aA:20.93"],["4W5T_A_IPHA902_0","PROTEIN ARGONAUTE-2","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ARG A 694;ILE A 154;ILE A 120;ASP A 117","None","0.97A","4w5tA-2y3aA:undetectable","4w5tA-2y3aA:20.93"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"ILE A 845;VAL A 848;THR A 853;MET A 920;ILE A 930","GD9 A2058 (-3.8A);GD9 A2058 (-3.8A);GD9 A2058 ( 4.8A);GD9 A2058 (-3.6A);GD9 A2058 (-4.2A)","1.01A","4xe0A-2y3aA:38.7","4xe0A-2y3aA:51.44"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",6,"MET A 773;PRO A 779;TYR A 833;ASP A 856;MET A 920;ILE A 930","GD9 A2058 (-4.3A);None;GD9 A2058 (-3.8A);GD9 A2058 ( 4.6A);GD9 A2058 (-3.6A);GD9 A2058 (-4.2A)","1.46A","4xe0A-2y3aA:38.7","4xe0A-2y3aA:51.44"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",6,"MET A 773;PRO A 779;TYR A 833;VAL A 848;MET A 920;ILE A 930","GD9 A2058 (-4.3A);None;GD9 A2058 (-3.8A);GD9 A2058 (-3.8A);GD9 A2058 (-3.6A);GD9 A2058 (-4.2A)","0.99A","4xe0A-2y3aA:38.7","4xe0A-2y3aA:51.44"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",7,"PRO A 779;ILE A 797;TYR A 833;ASP A 856;THR A 853;MET A 920;ILE A 930","None;None;GD9 A2058 (-3.8A);GD9 A2058 ( 4.6A);GD9 A2058 ( 4.8A);GD9 A2058 (-3.6A);GD9 A2058 (-4.2A)","1.25A","4xe0A-2y3aA:38.7","4xe0A-2y3aA:51.44"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",7,"PRO A 779;ILE A 797;TYR A 833;VAL A 848;THR A 853;MET A 920;ILE A 930","None;None;GD9 A2058 (-3.8A);GD9 A2058 (-3.8A);GD9 A2058 ( 4.8A);GD9 A2058 (-3.6A);GD9 A2058 (-4.2A)","0.66A","4xe0A-2y3aA:38.7","4xe0A-2y3aA:51.44"],["4XO7_A_ASDA402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"TYR A 608;VAL A1012;ILE A1015;LEU A1000","None","1.01A","4xo7A-2y3aA:undetectable","4xo7A-2y3aA:14.68"],["4Z4G_A_IPHA902_0","PROTEIN ARGONAUTE-2","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ARG A 694;ILE A 154;ILE A 120;ASP A 117","None","0.96A","4z4gA-2y3aA:undetectable","4z4gA-2y3aA:20.93"],["5CSW_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"PHE A  74;ILE A  49;ASP A  95","None","0.62A","5cswA-2y3aA:2.6","5cswA-2y3aA:14.49"],["5CSW_B_P06B801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"PHE A  74;ILE A  49;ASP A  95","None","0.66A","5cswB-2y3aA:2.9","5cswB-2y3aA:14.49"],["5HBS_A_RTLA201_1","RETINOL-BINDING PROTEIN 1","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"LEU A 633;LEU A 640;TYR A 692;TRP A 670","None","1.17A","5hbsA-2y3aA:undetectable","5hbsA-2y3aA:8.58"],["5IEP_A_VDYA201_2","CDL2.3B","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"PRO A 597;MET A 624;VAL A 639;LEU A1000;LEU A 567","None","1.50A","5iepA-2y3aA:undetectable","5iepA-2y3aA:8.38"],["5NWW_A_ACAA18_2","SCRFP-TAG,GP41","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"LYS A 922;TRP A 878;SER A 851","None;None;GD9 A2058 ( 4.5A)","1.23A","5nwwA-2y3aA:undetectable","5nwwA-2y3aA:3.00"],["5UHB_C_RFPC1201_2","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"PHE A 645;ASP A 647;LEU A 636","None","0.79A","5uhbC-2y3aA:2.1","5uhbC-2y3aA:22.06"],["5UHC_C_RFPC1201_2","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"PHE A 645;ASP A 647;LEU A 636","None","0.71A","5uhcC-2y3aA:undetectable","5uhcC-2y3aA:22.06"],["5VCE_A_RITA602_2","CYTOCHROME P450 3A4","2y3a","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA;PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ARG A1044;PHE B 671;PHE B 673;ILE B 640","None","1.06A","5vceA-2y3aA:undetectable","5vceA-2y3aA:18.48"],["5VEU_A_RITA602_2","CYTOCHROME P450 3A5","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"ARG A 147;PHE A 669;LEU A 655","None","0.85A","5veuA-2y3aA:undetectable","5veuA-2y3aA:19.15"],["5ZV2_A_LEVA801_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",3,"LYS A 776;LEU A 804;ASP A 931","None;None;GD9 A2058 (-3.2A)","0.89A","5zv2A-2y3aA:2.4","5zv2A-2y3aA:5.90"],["6AYC_A_1YNA502_2","PROTEIN CYP51","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"VAL A 950;PRO A 832;LEU A 831;LEU A 814","None","1.14A","6aycA-2y3aA:undetectable","6aycA-2y3aA:5.40"],["6CBD_A_TRPA903_0","PROTEIN ARGONAUTE-2","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"ARG A 694;ILE A 154;ILE A 120;ASP A 117","None","0.94A","6cbdA-2y3aA:undetectable","6cbdA-2y3aA:20.93"],["6DWD_A_GLYA717_0","DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"SER A 542;ARG A 538;ASP A 539;LYS A1019","None","1.40A","6dwdA-2y3aA:undetectable","6dwdA-2y3aA:18.95"],["6EKZ_A_SNPA414_0","AROMATIC PEROXYGENASE","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",4,"PHE A 645;VAL A 618;PRO A 609;MET A 391","None","1.30A","6ekzA-2y3aA:undetectable","6ekzA-2y3aA:6.14"],["6F3M_A_ADNA502_1","-","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"ASP A 660;HIS A 168;LEU A 157;GLY A 698;HIS A 699","None","1.28A","6f3mA-2y3aA:undetectable","6f3mA-2y3aA:17.32"],["6F3M_C_ADNC502_1","-","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"ASP A 660;HIS A 168;LEU A 157;GLY A 698;HIS A 699","None","1.29A","6f3mC-2y3aA:undetectable","6f3mC-2y3aA:17.32"],["6IBL_A_H98A501_0","THIOREDOXIN 1,BETA-1 ADRENERGIC RECEPTOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"THR A 475;VAL A 473;PHE A 442;PHE A 645;VAL A 139","None","1.44A","6iblA-2y3aA:undetectable","6iblA-2y3aA:17.36"],["6IBL_B_H98B501_0","THIOREDOXIN 1,BETA-1 ADRENERGIC RECEPTOR","2y3a","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","Mus musculus",5,"THR A 475;VAL A 473;PHE A 442;PHE A 645;VAL A 139","None","1.44A","6iblB-2y3aA:undetectable","6iblB-2y3aA:17.36"]]