SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		5 / 11 PHE A 174
SER A 149
LEU A 325
VAL A 102
PHE A 323
 None
 1.31A 1q23J-2y3cA:
undetectable		 1q23J-2y3cA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		4 / 8 LEU A 253
SER A 218
ARG A 324
GLU A 262
 None
None
None
CA  A1340 ( 3.4A)
 1.09A 2j2pA-2y3cA:
undetectable
2j2pB-2y3cA:
undetectable		 2j2pA-2y3cA:
22.92
2j2pB-2y3cA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		5 / 12 GLY A 299
ASP A 255
SER A 238
GLY A 237
SER A 236
 None
 1.03A 3g2oB-2y3cA:
undetectable		 3g2oB-2y3cA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		4 / 8 THR A 240
GLN A 104
SER A 116
HIS A 117
 None
None
None
ACT  A1334 ( 4.5A)
 1.03A 3kp2A-2y3cA:
undetectable
3kp2B-2y3cA:
undetectable		 3kp2A-2y3cA:
18.97
3kp2B-2y3cA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		4 / 5 ARG A 309
ILE A 271
HIS A  88
GLY A  78
 None
 1.01A 4e7cC-2y3cA:
undetectable		 4e7cC-2y3cA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		3 / 3 ASP A 266
ARG A 198
PRO A 200
 None
 1.03A 4wanC-2y3cA:
undetectable		 4wanC-2y3cA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		4 / 6 VAL A 110
LEU A 106
CYH A 145
LEU A 325
 None
 1.20A 5hrqB-2y3cA:
undetectable
5hrqI-2y3cA:
undetectable
5hrqJ-2y3cA:
undetectable		 5hrqB-2y3cA:
7.17
5hrqI-2y3cA:
5.80
5hrqJ-2y3cA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		3 / 3 ARG A 317
PRO A 115
ASN A 113
 None
 0.97A 5jwaA-2y3cA:
undetectable
5jwaH-2y3cA:
undetectable		 5jwaA-2y3cA:
20.49
5jwaH-2y3cA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		4 / 4 GLN A 128
THR A 127
THR A 100
LEU A 106
 None
 1.40A 5m5kA-2y3cA:
undetectable		 5m5kA-2y3cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1
(Treponema
denticola) 		4 / 4 GLN A 128
THR A 127
THR A 100
LEU A 106
 None
 1.39A 5m66B-2y3cA:
undetectable		 5m66B-2y3cA:
19.47