SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 8 ALA A 344
GLY A 247
VAL A 372
ILE A 400
 None
 0.58A 1d4yB-2y3sA:
undetectable		 1d4yB-2y3sA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 6 LEU A 277
TRP A 231
PHE A 239
VAL A 243
 None
 1.21A 1ibgH-2y3sA:
undetectable		 1ibgH-2y3sA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 8 VAL A 381
TYR A 264
GLY A 379
TYR A 343
 None
 0.96A 1jlfA-2y3sA:
3.0
1jlfB-2y3sA:
2.1		 1jlfA-2y3sA:
21.85
1jlfB-2y3sA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 1kifA-2y3sA:
undetectable		 1kifA-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 1kifB-2y3sA:
undetectable		 1kifB-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 1kifC-2y3sA:
undetectable		 1kifC-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 1kifD-2y3sA:
undetectable		 1kifD-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 1kifE-2y3sA:
undetectable		 1kifE-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 1kifF-2y3sA:
undetectable		 1kifF-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 1kifG-2y3sA:
undetectable		 1kifG-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 1kifH-2y3sA:
undetectable		 1kifH-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 4 ARG A 165
LEU A 180
ASN A 177
VAL A 157
 None
 0.96A 1lqtA-2y3sA:
undetectable		 1lqtA-2y3sA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 4 ARG A 165
LEU A 180
ASN A 177
VAL A 157
 None
 0.98A 1lqtB-2y3sA:
undetectable		 1lqtB-2y3sA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 4 ARG A 165
LEU A 180
ASN A 177
VAL A 157
 None
 0.97A 1lquA-2y3sA:
undetectable		 1lquA-2y3sA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 4 ARG A 165
LEU A 180
ASN A 177
VAL A 157
 None
 0.98A 1lquB-2y3sA:
undetectable		 1lquB-2y3sA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 7 VAL A 381
TYR A 264
GLY A 379
TYR A 343
 None
 0.93A 1lweA-2y3sA:
3.1		 1lweA-2y3sA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 11 GLY A 186
GLY A 187
VAL A 479
LEU A 476
LEU A 150
 None
 1.13A 1mx1A-2y3sA:
undetectable		 1mx1A-2y3sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 LEU A 150
ALA A 390
LEU A 476
VAL A 479
ILE A 131
 None
 0.92A 1s9pA-2y3sA:
undetectable		 1s9pA-2y3sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 LEU A 150
ALA A 390
LEU A 476
VAL A 479
ILE A 131
 None
 0.87A 1s9pC-2y3sA:
undetectable		 1s9pC-2y3sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 LEU A 150
ALA A 390
LEU A 476
VAL A 479
ILE A 131
 None
 0.85A 1s9pD-2y3sA:
undetectable		 1s9pD-2y3sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.20A 1ve9A-2y3sA:
undetectable		 1ve9A-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 ILE A 353
ARG A 351
LEU A 374
ILE A 400
PHE A 239
 None
 1.25A 1xzxX-2y3sA:
undetectable		 1xzxX-2y3sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		3 / 3 GLY A 247
GLU A 251
ASN A 245
 None
 0.71A 1zq9A-2y3sA:
undetectable		 1zq9A-2y3sA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 GLY A 442
SER A 396
VAL A 433
ALA A 443
TYR A 468
 None
 1.34A 2avdA-2y3sA:
undetectable		 2avdA-2y3sA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.19A 2du8G-2y3sA:
undetectable		 2du8G-2y3sA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 2du8J-2y3sA:
undetectable		 2du8J-2y3sA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		3 / 3 VAL A 450
ASP A 451
GLU A  65
 None
 0.48A 2qeuA-2y3sA:
undetectable		 2qeuA-2y3sA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		3 / 3 VAL A 450
ASP A 451
GLU A  65
 None
 0.49A 2qeuC-2y3sA:
undetectable		 2qeuC-2y3sA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 ASN A 446
GLY A 187
GLY A 133
LEU A 476
TYR A 468
 FAD  A 600 (-3.5A)
None
None
None
None
 1.22A 2zw9A-2y3sA:
undetectable		 2zw9A-2y3sA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 4 SER A 140
GLY A 144
GLY A 119
GLY A 135
 None
None
None
FAD  A 600 ( 3.8A)
 0.85A 3bogB-2y3sA:
undetectable
3bogD-2y3sA:
undetectable		 3bogB-2y3sA:
undetectable
3bogD-2y3sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 7 LYS A 107
ALA A 104
SER A  83
THR A 101
 GOL  A1501 (-4.5A)
None
None
None
 0.94A 3cfqA-2y3sA:
undetectable
3cfqB-2y3sA:
1.0		 3cfqA-2y3sA:
11.89
3cfqB-2y3sA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2y3s TAML
(Streptomyces
sp.
307-9) 		3 / 3 LEU A 294
LEU A 223
ARG A 314
 None
 0.67A 3hcnB-2y3sA:
undetectable		 3hcnB-2y3sA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2y3s TAML
(Streptomyces
sp.
307-9) 		3 / 3 ALA A 328
ARG A 323
LYS A 107
 None
GOL  A1501 (-4.5A)
GOL  A1501 (-4.5A)
 1.04A 3kp3B-2y3sA:
undetectable		 3kp3B-2y3sA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 10 VAL A 194
PHE A 489
ILE A  41
ALA A  48
VAL A  35
 FAD  A 600 ( 4.2A)
None
None
None
None
 1.06A 3me6A-2y3sA:
undetectable		 3me6A-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 9 VAL A 194
PHE A 489
ILE A  41
ALA A  48
VAL A  35
 FAD  A 600 ( 4.2A)
None
None
None
None
 1.06A 3me6C-2y3sA:
undetectable		 3me6C-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 9 VAL A 194
PHE A 489
ILE A  41
ALA A  48
VAL A  76
 FAD  A 600 ( 4.2A)
None
None
None
None
 1.23A 3me6C-2y3sA:
undetectable		 3me6C-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 9 VAL A 194
PHE A 489
ILE A  41
ALA A  48
VAL A  35
 FAD  A 600 ( 4.2A)
None
None
None
None
 1.04A 3me6D-2y3sA:
undetectable		 3me6D-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 9 VAL A 194
PHE A 489
ILE A  41
ALA A  48
VAL A  76
 FAD  A 600 ( 4.2A)
None
None
None
None
 1.21A 3me6D-2y3sA:
undetectable		 3me6D-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 LEU A 102
VAL A  85
TYR A 198
PRO A 118
TYR A 106
 None
 1.44A 3qlhA-2y3sA:
0.0		 3qlhA-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 LEU A 200
ARG A  91
TRP A 199
ILE A 168
 None
 1.29A 3ticD-2y3sA:
undetectable		 3ticD-2y3sA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 7 PRO A 218
ARG A 217
GLY A 212
PRO A 211
 None
 1.30A 3ucbB-2y3sA:
undetectable		 3ucbB-2y3sA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 9 ASN A 191
GLY A 188
GLY A 189
PHE A  67
GLY A 187
 None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
None
 1.26A 4h2gA-2y3sA:
undetectable		 4h2gA-2y3sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 GLY A 137
GLY A 119
LEU A 102
TYR A 444
TYR A 447
 FAD  A 600 ( 4.5A)
None
None
FAD  A 600 (-4.5A)
TIR  A 700 (-4.0A)
 1.04A 4lg1A-2y3sA:
undetectable		 4lg1A-2y3sA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 GLY A 137
GLY A 119
LEU A 102
TYR A 444
TYR A 447
 FAD  A 600 ( 4.5A)
None
None
FAD  A 600 (-4.5A)
TIR  A 700 (-4.0A)
 1.04A 4lg1B-2y3sA:
undetectable		 4lg1B-2y3sA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 GLY A 137
GLY A 119
LEU A 102
TYR A 444
TYR A 447
 FAD  A 600 ( 4.5A)
None
None
FAD  A 600 (-4.5A)
TIR  A 700 (-4.0A)
 1.05A 4lg1C-2y3sA:
undetectable		 4lg1C-2y3sA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 LEU A 200
ARG A  91
TRP A 199
ILE A 168
 None
 1.27A 4mwrA-2y3sA:
undetectable		 4mwrA-2y3sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		3 / 3 ARG A  91
TRP A 199
ILE A 168
 None
 1.05A 4mwxA-2y3sA:
undetectable		 4mwxA-2y3sA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 VAL A 384
SER A 396
ASN A 382
GLY A 144
LYS A 399
 None
 1.38A 4pevB-2y3sA:
undetectable		 4pevB-2y3sA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 TYR A 447
GLY A 120
TYR A  64
GLY A  61
 TIR  A 700 (-4.0A)
FAD  A 600 (-3.3A)
FAD  A 600 ( 4.6A)
FAD  A 600 (-3.3A)
 1.02A 5ayfA-2y3sA:
undetectable		 5ayfA-2y3sA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_2
(NEURAMINIDASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 4 LEU A 200
ARG A  91
TRP A 199
ILE A 168
 None
 1.30A 5l17A-2y3sA:
undetectable		 5l17A-2y3sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 HIS A 130
ALA A 121
GLY A 119
TYR A 106
 FAD  A 600 (-4.0A)
FAD  A 600 (-3.4A)
None
None
 1.17A 5yodB-2y3sA:
undetectable		 5yodB-2y3sA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		4 / 5 HIS A 130
ALA A 121
GLY A 119
TYR A 106
 FAD  A 600 (-4.0A)
FAD  A 600 (-3.4A)
None
None
 1.20A 5yodD-2y3sA:
undetectable		 5yodD-2y3sA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2y3s TAML
(Streptomyces
sp.
307-9) 		5 / 12 GLY A 190
HIS A 491
VAL A 167
VAL A 157
ASP A 484
 FAD  A 600 (-4.0A)
FAD  A 600 ( 4.6A)
None
None
None
 1.40A 6bxlB-2y3sA:
undetectable		 6bxlB-2y3sA:
23.58