SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		5 / 12 LEU A 169
THR A  67
LEU A  66
LEU A  58
LEU A  55
 None
 1.25A 1mx1C-2y4fA:
undetectable		 1mx1C-2y4fA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 6 LEU A 371
LEU A 101
LEU A 107
LEU A 122
 None
 1.05A 2ab2A-2y4fA:
undetectable		 2ab2A-2y4fA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 8 PHE A  63
LEU A 144
LEU A 169
LEU A  55
 None
 0.93A 2bfpC-2y4fA:
undetectable		 2bfpC-2y4fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		5 / 7 ILE A 179
MET A  37
GLN A 145
LEU A  39
LEU A 331
 None
None
None
None
HEM  A 389 (-4.2A)
 1.50A 2qqcB-2y4fA:
undetectable
2qqcC-2y4fA:
undetectable		 2qqcB-2y4fA:
13.38
2qqcC-2y4fA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		5 / 7 LEU A  39
LEU A 331
ILE A 179
MET A  37
GLN A 145
 None
HEM  A 389 (-4.2A)
None
None
None
 1.48A 2qqcA-2y4fA:
undetectable
2qqcF-2y4fA:
undetectable		 2qqcA-2y4fA:
9.30
2qqcF-2y4fA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 7 ILE A 240
ARG A 238
ASP A 131
GLY A 364
 HEM  A 389 (-3.6A)
None
None
None
 0.94A 2qqcD-2y4fA:
undetectable
2qqcE-2y4fA:
undetectable		 2qqcD-2y4fA:
13.38
2qqcE-2y4fA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		5 / 7 LEU A  39
LEU A 331
ILE A 179
MET A  37
GLN A 145
 None
HEM  A 389 (-4.2A)
None
None
None
 1.48A 2qqcI-2y4fA:
undetectable
2qqcL-2y4fA:
undetectable		 2qqcI-2y4fA:
9.30
2qqcL-2y4fA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 5 GLN A 235
ALA A 370
GLN A  26
ILE A  29
 None
 1.26A 2z0aA-2y4fA:
undetectable		 2z0aA-2y4fA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 7 ASP A  13
SER A  11
SER A 186
GLU A 190
 None
 1.33A 3bc9A-2y4fA:
undetectable		 3bc9A-2y4fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 4 ASP A 376
GLY A  23
LYS A 375
GLU A  24
 None
 1.43A 3hznD-2y4fA:
0.8		 3hznD-2y4fA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		3 / 3 PRO A  94
ASP A  95
GLU A  17
 None
 0.79A 3v4tC-2y4fA:
undetectable		 3v4tC-2y4fA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 6 LEU A 386
PHE A  56
LEU A  52
PHE A 112
 None
 1.06A 3wg7C-2y4fA:
undetectable
3wg7J-2y4fA:
undetectable		 3wg7C-2y4fA:
20.78
3wg7J-2y4fA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 6 LEU A 386
PHE A  56
LEU A  52
PHE A 112
 None
 1.01A 3wg7P-2y4fA:
undetectable
3wg7W-2y4fA:
undetectable		 3wg7P-2y4fA:
20.78
3wg7W-2y4fA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		3 / 3 GLN A 214
ASP A 222
GLN A 223
 None
 0.84A 4aztA-2y4fA:
undetectable		 4aztA-2y4fA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 4 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.17A 4f3tA-2y4fA:
undetectable		 4f3tA-2y4fA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 6 TYR A 317
ARG A 175
ILE A 363
GLY A 365
 None
SO4  A 400 (-3.9A)
None
None
 0.97A 4l39A-2y4fA:
undetectable		 4l39A-2y4fA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		5 / 11 LEU A  97
GLN A  34
ALA A 148
THR A  31
ILE A  29
 None
 1.29A 4uuuA-2y4fA:
undetectable
4uuuB-2y4fA:
undetectable		 4uuuA-2y4fA:
18.68
4uuuB-2y4fA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 5 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.17A 4w5oA-2y4fA:
undetectable		 4w5oA-2y4fA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 4 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.08A 4w5qA-2y4fA:
undetectable		 4w5qA-2y4fA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 7 ILE A 295
LEU A 297
ALA A 290
ILE A 289
 HEM  A 389 (-4.5A)
None
None
None
 0.83A 4y03A-2y4fA:
undetectable		 4y03A-2y4fA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 5 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.14A 4z4cA-2y4fA:
undetectable		 4z4cA-2y4fA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 5 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.17A 4z4dA-2y4fA:
undetectable		 4z4dA-2y4fA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 5 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.17A 4z4eA-2y4fA:
undetectable		 4z4eA-2y4fA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 4 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.12A 4z4gA-2y4fA:
0.2		 4z4gA-2y4fA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		3 / 3 PHE A  63
ILE A 146
ASP A  95
 None
 0.76A 5cswA-2y4fA:
0.4		 5cswA-2y4fA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		3 / 3 TYR A 234
LYS A 120
LYS A 121
 None
SO4  A 405 (-4.4A)
None
 1.35A 5dbyA-2y4fA:
undetectable		 5dbyA-2y4fA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 4 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.14A 5ki6A-2y4fA:
0.7		 5ki6A-2y4fA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		4 / 6 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.14A 5t7bA-2y4fA:
undetectable		 5t7bA-2y4fA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2y4f PEROXIDASE YCDB
(Escherichia
coli) 		3 / 3 ARG A 301
ARG A 312
ARG A 261
 HEM  A 389 (-3.6A)
HEM  A 389 (-2.8A)
None
 0.95A 6bplA-2y4fA:
undetectable
6bplB-2y4fA:
undetectable		 6bplA-2y4fA:
11.70
6bplB-2y4fA:
11.70