SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 11 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.32A 1cmaA-2y4lA:
undetectable
1cmaB-2y4lA:
undetectable		 1cmaA-2y4lA:
13.06
1cmaB-2y4lA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 8 MET A 229
ALA A 236
LEU A 194
LEU A 163
 MLI  A 402 ( 4.1A)
None
None
MLI  A 402 (-4.6A)
 0.77A 1ereE-2y4lA:
undetectable		 1ereE-2y4lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 8 MET A 229
ALA A 236
LEU A 194
LEU A 163
 MLI  A 402 ( 4.1A)
None
None
MLI  A 402 (-4.6A)
 0.79A 1ereF-2y4lA:
undetectable		 1ereF-2y4lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 7 TRP A 282
LEU A 278
THR A 345
LEU A 340
LEU A 301
 None
 1.37A 1gtiA-2y4lA:
undetectable		 1gtiA-2y4lA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 12 ALA A  83
GLY A  79
GLU A  90
GLU A  31
LEU A  33
 None
GDP  A 401 ( 3.8A)
None
None
None
 1.30A 1mjoC-2y4lA:
undetectable
1mjoD-2y4lA:
undetectable		 1mjoC-2y4lA:
13.03
1mjoD-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 11 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.30A 1mjqA-2y4lA:
undetectable
1mjqB-2y4lA:
undetectable		 1mjqA-2y4lA:
13.03
1mjqB-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 10 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.28A 1mjqC-2y4lA:
undetectable
1mjqD-2y4lA:
undetectable		 1mjqC-2y4lA:
13.03
1mjqD-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 10 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.29A 1mjqG-2y4lA:
undetectable
1mjqH-2y4lA:
undetectable		 1mjqG-2y4lA:
13.03
1mjqH-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 11 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.28A 1mjqI-2y4lA:
undetectable
1mjqJ-2y4lA:
undetectable		 1mjqI-2y4lA:
13.03
1mjqJ-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 6 TYR A 207
TYR A 122
GLU A 254
PRO A 256
 EDO  A 502 ( 4.5A)
EDO  A 506 ( 3.7A)
None
None
 1.37A 1q13A-2y4lA:
undetectable		 1q13A-2y4lA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		3 / 3 TRP A 344
THR A 274
TYR A 269
 None
 1.00A 2a3aA-2y4lA:
undetectable		 2a3aA-2y4lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		3 / 3 TRP A 344
THR A 274
TYR A 269
 None
 1.03A 2a3aB-2y4lA:
undetectable		 2a3aB-2y4lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		3 / 3 TRP A 344
THR A 274
TYR A 269
 None
 1.03A 2a3bA-2y4lA:
undetectable		 2a3bA-2y4lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 5 LEU A 325
LEU A 230
ILE A 142
ALA A 235
 None
 0.69A 2i2zA-2y4lA:
undetectable		 2i2zA-2y4lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		3 / 3 LEU A  33
LEU A 168
MET A 169
 None
 0.70A 2itzA-2y4lA:
undetectable		 2itzA-2y4lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 5 LEU A 278
ASP A 224
ALA A 273
PHE A 341
 None
 1.00A 2opxA-2y4lA:
3.8		 2opxA-2y4lA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 5 ILE A 211
PRO A 212
TYR A 210
TYR A 128
 None
 1.23A 3d9lA-2y4lA:
undetectable
3d9lY-2y4lA:
undetectable		 3d9lA-2y4lA:
16.58
3d9lY-2y4lA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 8 LEU A 357
THR A 352
TYR A 351
GLY A 268
ALA A 132
 None
 1.48A 3jusB-2y4lA:
undetectable		 3jusB-2y4lA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 9 LEU A 357
THR A 352
TYR A 351
GLY A 268
ALA A 132
 None
 1.48A 3jusB-2y4lA:
undetectable		 3jusB-2y4lA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 7 TYR A 366
VAL A 355
TRP A 140
ASN A 350
 None
None
None
EDO  A 503 (-4.0A)
 1.10A 3kmoB-2y4lA:
undetectable		 3kmoB-2y4lA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 7 VAL A 200
ILE A 206
SER A 157
ARG A 144
 None
 1.00A 3pglA-2y4lA:
3.4		 3pglA-2y4lA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 12 MET A 229
ALA A 236
LEU A 194
GLY A 164
LEU A 163
 MLI  A 402 ( 4.1A)
None
None
None
MLI  A 402 (-4.6A)
 1.06A 3q95B-2y4lA:
undetectable		 3q95B-2y4lA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 12 GLN A 247
GLY A 203
GLY A 246
GLU A 155
ALA A 249
 None
 1.10A 3t7sA-2y4lA:
2.9		 3t7sA-2y4lA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 12 GLN A 247
GLY A 203
GLY A 246
GLU A 155
ALA A 249
 None
 1.15A 3t7sC-2y4lA:
2.3		 3t7sC-2y4lA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 8 LEU A  84
ILE A 191
VAL A 198
THR A 199
 None
 0.94A 4ma7A-2y4lA:
undetectable		 4ma7A-2y4lA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		3 / 3 ARG A 144
GLN A 161
GLU A 160
 None
 0.84A 4tvtA-2y4lA:
undetectable		 4tvtA-2y4lA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 8 SER A 157
ALA A 378
LEU A 149
GLY A 146
 None
 0.91A 4xk8a-2y4lA:
undetectable		 4xk8a-2y4lA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		3 / 5 GLY A  77
GLY A 190
GLU A 232
 None
 0.48A 4z2eA-2y4lA:
undetectable
4z2eD-2y4lA:
undetectable		 4z2eA-2y4lA:
22.07
4z2eD-2y4lA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 5 ALA A 319
TYR A 322
GLY A 203
LEU A 240
 None
 0.93A 5eslA-2y4lA:
undetectable		 5eslA-2y4lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 5 LEU A 343
PHE A 341
LEU A 301
PHE A 312
 None
 1.23A 5iy5P-2y4lA:
undetectable
5iy5W-2y4lA:
undetectable		 5iy5P-2y4lA:
23.70
5iy5W-2y4lA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		6 / 12 GLU A 208
VAL A 173
LEU A 177
VAL A 204
ARG A 144
ILE A 206
 None
 1.40A 5vopA-2y4lA:
undetectable		 5vopA-2y4lA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 5 LEU A 343
PHE A 341
LEU A 301
PHE A 312
 None
 1.20A 5xdxC-2y4lA:
undetectable
5xdxJ-2y4lA:
undetectable		 5xdxC-2y4lA:
23.16
5xdxJ-2y4lA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		4 / 5 LEU A 343
PHE A 341
LEU A 301
PHE A 312
 None
 1.25A 5xdxP-2y4lA:
undetectable
5xdxW-2y4lA:
undetectable		 5xdxP-2y4lA:
23.16
5xdxW-2y4lA:
8.53