SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 218
THR A 121
SER A 124
ILE A 125
LEU A 136
 DLL  A1441 ( 3.7A)
None
None
None
None
 0.88A 1ddrA-2y4oA:
undetectable		 1ddrA-2y4oA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 218
THR A 121
SER A 124
ILE A 125
LEU A 136
 DLL  A1441 ( 3.7A)
None
None
None
None
 0.90A 1rg7A-2y4oA:
undetectable		 1rg7A-2y4oA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 409
ILE A 404
VAL A 337
SER A 412
 None
 0.97A 1rs7B-2y4oA:
undetectable		 1rs7B-2y4oA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.81A 1usqA-2y4oA:
undetectable		 1usqA-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.80A 1usqB-2y4oA:
undetectable		 1usqB-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.81A 1usqC-2y4oA:
undetectable		 1usqC-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.82A 1usqD-2y4oA:
undetectable		 1usqD-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.82A 1usqE-2y4oA:
undetectable		 1usqE-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.82A 1usqF-2y4oA:
undetectable		 1usqF-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  61
LEU A  64
ARG A 306
SER A  70
 None
 1.11A 2hc4A-2y4oA:
undetectable		 2hc4A-2y4oA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.77A 2jkjA-2y4oA:
undetectable		 2jkjA-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.76A 2jkjB-2y4oA:
undetectable		 2jkjB-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.77A 2jkjC-2y4oA:
undetectable		 2jkjC-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.77A 2jkjE-2y4oA:
undetectable		 2jkjE-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.78A 2jklA-2y4oA:
undetectable		 2jklA-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.77A 2jklB-2y4oA:
undetectable		 2jklB-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.78A 2jklC-2y4oA:
undetectable		 2jklC-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.80A 2jklD-2y4oA:
undetectable		 2jklD-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.78A 2jklE-2y4oA:
undetectable		 2jklE-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.79A 2jklF-2y4oA:
undetectable		 2jklF-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A 374
LEU A 365
GLU A 348
ARG A 432
 None
 0.87A 2jn3A-2y4oA:
undetectable		 2jn3A-2y4oA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A 324
TYR A 241
GLY A 217
 None
DLL  A1441 (-4.8A)
DLL  A1441 ( 3.8A)
 0.61A 2ocuA-2y4oA:
undetectable		 2ocuA-2y4oA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 PRO A 182
ILE A 235
LEU A 211
LEU A 186
ILE A 215
 None
 1.08A 3a50D-2y4oA:
undetectable		 3a50D-2y4oA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 11 THR A 296
THR A 116
PHE A 269
VAL A 302
ILE A 303
 None
 1.48A 3ijdA-2y4oA:
1.0		 3ijdA-2y4oA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLU A 280
GLY A 279
LEU A 282
GLU A 289
 None
 0.89A 3w9tB-2y4oA:
undetectable		 3w9tB-2y4oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLU A 280
GLY A 279
LEU A 282
GLU A 289
 None
 0.89A 3w9tE-2y4oA:
undetectable		 3w9tE-2y4oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLU A 280
GLY A 279
LEU A 282
GLU A 289
 None
 0.90A 3w9tF-2y4oA:
undetectable		 3w9tF-2y4oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 9 ILE A 151
LEU A 136
ILE A 184
ILE A 185
ILE A 213
 None
 0.88A 3zosA-2y4oA:
undetectable		 3zosA-2y4oA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 9 LEU A 193
ILE A 151
LEU A 136
ILE A 184
ILE A 213
 None
 1.24A 3zosB-2y4oA:
undetectable		 3zosB-2y4oA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 218
THR A 121
SER A 124
ILE A 125
LEU A 136
 DLL  A1441 ( 3.7A)
None
None
None
None
 0.96A 4dfrA-2y4oA:
undetectable		 4dfrA-2y4oA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 10 ILE A 151
GLY A 148
GLY A 141
THR A 188
PHE A 216
 None
 0.99A 4fakA-2y4oA:
undetectable		 4fakA-2y4oA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 ILE A 240
GLY A 147
PHE A 140
TYR A 109
 DLL  A1441 (-4.7A)
DLL  A1441 (-3.6A)
DLL  A1441 (-3.6A)
None
 0.92A 4iqqA-2y4oA:
undetectable		 4iqqA-2y4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 ILE A 240
GLY A 147
PHE A 140
TYR A 109
 DLL  A1441 (-4.7A)
DLL  A1441 (-3.6A)
DLL  A1441 (-3.6A)
None
 0.78A 4iqqD-2y4oA:
undetectable		 4iqqD-2y4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 ILE A 240
GLY A 147
PHE A 140
TYR A 109
 DLL  A1441 (-4.7A)
DLL  A1441 (-3.6A)
DLL  A1441 (-3.6A)
None
 0.90A 5h3aA-2y4oA:
undetectable		 5h3aA-2y4oA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A 342
SER A 412
MET A 371
 None
 0.82A 5ikqA-2y4oA:
undetectable		 5ikqA-2y4oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 TYR A 305
THR A 105
GLU A 245
GLY A 248
VAL A 251
 None
None
DLL  A1441 ( 4.6A)
DLL  A1441 ( 4.4A)
None
 1.45A 5jo9A-2y4oA:
5.5		 5jo9A-2y4oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 10 LEU A 313
ILE A 264
ARG A 322
PHE A 292
VAL A 291
 None
 1.27A 5m0oA-2y4oA:
undetectable		 5m0oA-2y4oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 ILE A 240
GLY A 147
PHE A 140
TYR A 109
 DLL  A1441 (-4.7A)
DLL  A1441 (-3.6A)
DLL  A1441 (-3.6A)
None
 0.78A 5nooD-2y4oA:
undetectable		 5nooD-2y4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A  65
TYR A  38
ASP A  49
PHE A  48
THR A  47
 None
 1.42A 5vlmD-2y4oA:
undetectable		 5vlmD-2y4oA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 ASP A 197
SER A 209
LEU A 211
ILE A 177
HIS A 370
 None
MG  A1439 (-3.5A)
None
None
None
 1.45A 6ccvC-2y4oA:
0.0		 6ccvC-2y4oA:
18.70