SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		4 / 4 ALA A  62
ARG A 102
GLN A  65
GLU A  66
 None
CL  A1275 (-3.3A)
None
None
 0.94A 1lqtB-2y4rA:
undetectable		 1lqtB-2y4rA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		4 / 4 ALA A  62
ARG A 102
GLN A  65
GLU A  66
 None
CL  A1275 (-3.3A)
None
None
 0.92A 1lquB-2y4rA:
undetectable		 1lquB-2y4rA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  49
ARG A  52
ARG A  53
LEU A 139
ALA A 198
 PG4  A1272 (-3.6A)
None
PG4  A1272 ( 4.5A)
None
PG4  A1272 ( 4.1A)
 1.18A 1mj2A-2y4rA:
undetectable		 1mj2A-2y4rA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  49
ARG A  52
ARG A  53
LEU A 139
ALA A 198
 PG4  A1272 (-3.6A)
None
PG4  A1272 ( 4.5A)
None
PG4  A1272 ( 4.1A)
 1.24A 1mj2C-2y4rA:
undetectable		 1mj2C-2y4rA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		5 / 11 GLU A  49
ARG A  52
ARG A  53
LEU A 139
ALA A 198
 PG4  A1272 (-3.6A)
None
PG4  A1272 ( 4.5A)
None
PG4  A1272 ( 4.1A)
 1.14A 1mjlA-2y4rA:
undetectable
1mjlB-2y4rA:
undetectable		 1mjlA-2y4rA:
16.85
1mjlB-2y4rA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  49
ARG A  52
ARG A  53
LEU A 139
ALA A 198
 PG4  A1272 (-3.6A)
None
PG4  A1272 ( 4.5A)
None
PG4  A1272 ( 4.1A)
 1.21A 1mjoA-2y4rA:
undetectable		 1mjoA-2y4rA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  49
ARG A  52
ARG A  53
LEU A 139
ALA A 198
 PG4  A1272 (-3.6A)
None
PG4  A1272 ( 4.5A)
None
PG4  A1272 ( 4.1A)
 1.20A 1mjoB-2y4rA:
undetectable		 1mjoB-2y4rA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  49
ARG A  52
ARG A  53
LEU A 139
ALA A 198
 PG4  A1272 (-3.6A)
None
PG4  A1272 ( 4.5A)
None
PG4  A1272 ( 4.1A)
 1.21A 1mjoC-2y4rA:
undetectable		 1mjoC-2y4rA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 183
VAL A 171
ARG A 219
 None
 0.90A 3b0wB-2y4rA:
undetectable		 3b0wB-2y4rA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 123
GLY A 162
ASN A 236
SER A 177
LEU A 179
 None
None
PLP  A1140 (-4.6A)
None
None
 1.33A 3ndvA-2y4rA:
undetectable
3ndvB-2y4rA:
undetectable		 3ndvA-2y4rA:
22.90
3ndvB-2y4rA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 162
ASN A 236
SER A 177
LEU A 179
LEU A 123
 None
PLP  A1140 (-4.6A)
None
None
None
 1.33A 3ndvC-2y4rA:
undetectable
3ndvD-2y4rA:
undetectable		 3ndvC-2y4rA:
22.90
3ndvD-2y4rA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 142
GLY A  23
GLY A  25
THR A  84
 None
 0.89A 3si7A-2y4rA:
undetectable		 3si7A-2y4rA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  81
VAL A   5
ASP A   6
 None
 0.64A 4y8wC-2y4rA:
undetectable		 4y8wC-2y4rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A  85
ARG A  52
GLY A  50
GLU A  49
 None
None
None
PG4  A1272 (-3.6A)
 1.19A 4z3oA-2y4rA:
undetectable
4z3oB-2y4rA:
undetectable		 4z3oA-2y4rA:
18.56
4z3oB-2y4rA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A  85
ARG A  52
GLY A  50
GLU A  49
 None
None
None
PG4  A1272 (-3.6A)
 0.91A 5btcA-2y4rA:
undetectable
5btcC-2y4rA:
undetectable
5btcD-2y4rA:
undetectable		 5btcA-2y4rA:
22.59
5btcC-2y4rA:
22.59
5btcD-2y4rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A  52
GLY A  50
GLU A  49
ARG A  85
 None
None
PG4  A1272 (-3.6A)
None
 0.91A 5btcA-2y4rA:
undetectable
5btcB-2y4rA:
undetectable
5btcC-2y4rA:
undetectable		 5btcA-2y4rA:
22.59
5btcB-2y4rA:
23.81
5btcC-2y4rA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  17
LEU A 139
PRO A 100
ARG A 101
LEU A  58
 None
 1.33A 5syfB-2y4rA:
undetectable		 5syfB-2y4rA:
21.28