SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		3 / 3 SER A 317
GLU A 320
GLU A 348
 None
 0.67A 1eqbD-2y4tA:
undetectable		 1eqbD-2y4tA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		3 / 3 SER A 317
GLU A 320
GLU A 348
 None
 0.68A 1eqbB-2y4tA:
undetectable		 1eqbB-2y4tA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		3 / 3 LYS A  96
ARG A  77
LYS A  34
 None
 1.07A 3okxA-2y4tA:
undetectable		 3okxA-2y4tA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		4 / 5 TYR A 262
ILE A 208
LEU A 211
LYS A 212
 None
 1.02A 3sueC-2y4tA:
undetectable		 3sueC-2y4tA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		3 / 3 LYS A 397
TYR A 396
ARG A 403
 None
 1.35A 4gc9A-2y4tA:
undetectable		 4gc9A-2y4tA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		3 / 3 ASP A 122
LEU A 115
VAL A 183
 None
 0.69A 4jecB-2y4tA:
undetectable		 4jecB-2y4tA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		3 / 3 ARG A 194
GLU A 182
ARG A 191
 None
 0.98A 4mwvA-2y4tA:
undetectable		 4mwvA-2y4tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		4 / 8 GLY A 112
GLN A 110
PHE A 128
HIS A 113
 None
 1.03A 4wryA-2y4tA:
undetectable		 4wryA-2y4tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		4 / 8 GLY A 112
GLN A 110
PHE A 128
HIS A 113
 None
 1.01A 4wrzA-2y4tA:
undetectable		 4wrzA-2y4tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		4 / 5 ILE A 174
ARG A 194
CYH A 197
GLU A 196
 None
 1.08A 5fseC-2y4tA:
0.0		 5fseC-2y4tA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens) 		4 / 6 VAL A 183
LEU A 116
LEU A 121
LEU A 148
 None
 0.81A 6f6sA-2y4tA:
undetectable
6f6sB-2y4tA:
undetectable		 6f6sA-2y4tA:
13.02
6f6sB-2y4tA:
10.23