SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 118
VAL A 150
LEU A 133
ILE A 143
LEU A 168
 None
 1.14A 1eqgA-2y4yA:
undetectable		 1eqgA-2y4yA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 118
VAL A 150
LEU A 133
ILE A 143
LEU A 168
 None
 1.16A 1eqgB-2y4yA:
undetectable		 1eqgB-2y4yA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 137
PRO A 155
VAL A 154
ILE A 153
 None
 0.97A 2aoiA-2y4yA:
undetectable		 2aoiA-2y4yA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 164
GLY A 138
ASP A 137
GLY A 134
 None
 0.79A 4koeA-2y4yA:
undetectable
4koeB-2y4yA:
undetectable
4koeC-2y4yA:
undetectable		 4koeA-2y4yA:
11.91
4koeB-2y4yA:
11.91
4koeC-2y4yA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 164
GLY A 138
ASP A 137
GLY A 134
 None
 0.78A 4koeA-2y4yA:
undetectable
4koeB-2y4yA:
undetectable
4koeD-2y4yA:
undetectable		 4koeA-2y4yA:
11.91
4koeB-2y4yA:
11.91
4koeD-2y4yA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  86
GLY A 134
ILE A  99
VAL A 154
ILE A 153
 None
 1.08A 4q1wB-2y4yA:
undetectable		 4q1wB-2y4yA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 138
ASP A 137
GLY A 134
ARG A 164
 None
 0.89A 4z53A-2y4yA:
undetectable
4z53B-2y4yA:
undetectable		 4z53A-2y4yA:
9.76
4z53B-2y4yA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 164
GLY A 138
ASP A 137
GLY A 134
 None
 0.81A 4z53A-2y4yA:
undetectable
4z53B-2y4yA:
undetectable		 4z53A-2y4yA:
9.76
4z53B-2y4yA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 148
LEU A 168
ARG A 126
LEU A  94
 None
None
ACT  A1173 (-3.0A)
None
 1.01A 5b1bA-2y4yA:
undetectable
5b1bJ-2y4yA:
undetectable		 5b1bA-2y4yA:
9.02
5b1bJ-2y4yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 148
LEU A 168
ARG A 126
LEU A  94
 None
None
ACT  A1173 (-3.0A)
None
 0.98A 5b3sA-2y4yA:
undetectable
5b3sJ-2y4yA:
undetectable		 5b3sA-2y4yA:
9.02
5b3sJ-2y4yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 2y4y PILP PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 152
LEU A 133
ARG A 135
ARG A 166
 None
 1.05A 5l6eA-2y4yA:
undetectable
5l6eB-2y4yA:
undetectable		 5l6eA-2y4yA:
17.22
5l6eB-2y4yA:
15.11