SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MGH_A_ACTA1320_0 (PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE)	2y5c	ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL (Homo sapiens)	4 / 5	VAL A 56 LEU A 64 ILE A 91 ARG A 86	None	0.87A	4mghA-2y5cA: undetectable	4mghA-2y5cA: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DX3_A_ESTA601_1 (ESTROGEN RECEPTOR)	2y5c	ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL (Homo sapiens)	5 / 10	ALA A 100 GLU A 101 ARG A 17 GLY A 22 LEU A 93	None	1.34A	5dx3A-2y5cA: undetectable	5dx3A-2y5cA: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DXB_A_ESTA1000_1 (ESTROGEN RECEPTOR)	2y5c	ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL (Homo sapiens)	5 / 10	ALA A 100 GLU A 101 ARG A 17 GLY A 22 LEU A 93	None	1.32A	5dxbA-2y5cA: undetectable	5dxbA-2y5cA: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UBB_A_SAMA301_0 (ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1B)	2y5c	ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL (Homo sapiens)	5 / 12	GLY A 88 LEU A 39 VAL A 54 HIS A 53 LEU A 104	None	1.00A	5ubbA-2y5cA: undetectable	5ubbA-2y5cA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WGQ_A_ESTA601_1 (ESTROGEN RECEPTOR)	2y5c	ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL (Homo sapiens)	5 / 9	ALA A 100 GLU A 101 ARG A 17 GLY A 22 LEU A 93	None	1.35A	5wgqA-2y5cA: undetectable	5wgqA-2y5cA: 23.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4MGH_A_ACTA1320_0","PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE","2y5c","ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL","Homo sapiens",4,"VAL A  56;LEU A  64;ILE A  91;ARG A  86","None","0.87A","4mghA-2y5cA:undetectable","4mghA-2y5cA:6.23"],["5DX3_A_ESTA601_1","ESTROGEN RECEPTOR","2y5c","ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL","Homo sapiens",5,"ALA A 100;GLU A 101;ARG A  17;GLY A  22;LEU A  93","None","1.34A","5dx3A-2y5cA:undetectable","5dx3A-2y5cA:18.32"],["5DXB_A_ESTA1000_1","ESTROGEN RECEPTOR","2y5c","ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL","Homo sapiens",5,"ALA A 100;GLU A 101;ARG A  17;GLY A  22;LEU A  93","None","1.32A","5dxbA-2y5cA:undetectable","5dxbA-2y5cA:18.32"],["5UBB_A_SAMA301_0","ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1B","2y5c","ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL","Homo sapiens",5,"GLY A  88;LEU A  39;VAL A  54;HIS A  53;LEU A 104","None","1.00A","5ubbA-2y5cA:undetectable","5ubbA-2y5cA:19.55"],["5WGQ_A_ESTA601_1","ESTROGEN RECEPTOR","2y5c","ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL","Homo sapiens",5,"ALA A 100;GLU A 101;ARG A  17;GLY A  22;LEU A  93","None","1.35A","5wgqA-2y5cA:undetectable","5wgqA-2y5cA:23.68"]]