SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		5 / 12 ASP A 101
ASN A 120
ASP A 191
GLY A 229
SER A 231
 None
None
None
None
EDO  A1294 (-2.6A)
 0.72A 1q8jA-2y5jA:
8.8		 1q8jA-2y5jA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		4 / 5 GLY A 140
PRO A 225
ALA A 265
ILE A 266
 None
 0.85A 2aofA-2y5jA:
undetectable		 2aofA-2y5jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A  22
PRO A 225
ALA A 265
ILE A 266
 None
 0.99A 2aofB-2y5jA:
undetectable		 2aofB-2y5jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		4 / 5 PRO A 105
ALA A 106
ASP A 121
ASP A 191
 None
 1.12A 2nyuB-2y5jA:
undetectable		 2nyuB-2y5jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		5 / 12 ASP A 101
ASN A 120
ASP A 191
GLY A 229
SER A 231
 None
None
None
None
EDO  A1294 (-2.6A)
 0.77A 2ycjA-2y5jA:
20.7		 2ycjA-2y5jA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		6 / 10 LEU A  22
ASP A  62
GLY A 140
PRO A 225
ALA A 265
ILE A 266
 None
 1.31A 3ekpB-2y5jA:
undetectable		 3ekpB-2y5jA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		6 / 10 LEU A  22
ASP A  62
GLY A 140
PRO A 225
ALA A 265
ILE A 266
 None
 1.40A 3ekpC-2y5jA:
undetectable		 3ekpC-2y5jA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		4 / 7 VAL A 272
VAL A 276
LEU A 279
SER A 280
 None
EDO  A1295 (-3.3A)
EDO  A1295 (-3.5A)
None
 0.80A 3hs6B-2y5jA:
undetectable		 3hs6B-2y5jA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		4 / 6 ALA A  50
ILE A  54
LEU A  61
ALA A  90
 None
 0.83A 3r9sA-2y5jA:
undetectable		 3r9sA-2y5jA:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  87
ALA A  50
GLY A  25
ILE A  26
 None
 0.87A 3spkB-2y5jA:
undetectable		 3spkB-2y5jA:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		3 / 3 PHE A 196
LYS A 233
SER A 234
 None
 0.44A 3tyeB-2y5jA:
33.0		 3tyeB-2y5jA:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		4 / 8 GLY A 195
PHE A 196
LYS A 233
SER A 234
 None
 0.68A 3tzfB-2y5jA:
34.4		 3tzfB-2y5jA:
47.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		6 / 12 ASP A  62
ASP A 101
ASN A 120
ASP A 191
GLY A 229
SER A 231
 None
None
None
None
None
EDO  A1294 (-2.6A)
 0.74A 4djeB-2y5jA:
20.3		 4djeB-2y5jA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		5 / 12 ASP A  62
ASP A 101
ASN A 120
GLY A 229
SER A 231
 None
None
None
None
EDO  A1294 (-2.6A)
 0.79A 4djfB-2y5jA:
17.6		 4djfB-2y5jA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A 118
ASP A 101
ARG A 268
ILE A  26
 None
 1.33A 4mwrA-2y5jA:
undetectable		 4mwrA-2y5jA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 246
VAL A 249
SER A 252
ALA A 274
LEU A  27
 None
None
EDO  A1294 (-3.4A)
None
None
 1.29A 4nc3A-2y5jA:
undetectable		 4nc3A-2y5jA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		5 / 9 ARG A  49
ALA A  50
GLY A  25
LEU A  61
LEU A  91
 None
 1.17A 5dqfA-2y5jA:
undetectable		 5dqfA-2y5jA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		3 / 3 ASP A 101
ASN A 120
ASP A 191
 None
 0.61A 5vopA-2y5jA:
17.6		 5vopA-2y5jA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2y5j DIHYDROPTEROATE
SYNTHASE
(Burkholderia
cenocepacia) 		3 / 3 ASP A 101
ASN A 120
ASP A 191
 None
 0.62A 5vopB-2y5jA:
7.9		 5vopB-2y5jA:
24.69