SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
 None
 1.36A 1e7wA-2y5qA:
undetectable		 1e7wA-2y5qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 LEU A 119
LEU A 110
LEU A 125
LEU A 127
LEU A 141
 None
 1.14A 1mx1C-2y5qA:
undetectable		 1mx1C-2y5qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 8 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
 None
 1.41A 2bfpB-2y5qA:
undetectable		 2bfpB-2y5qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 8 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
 None
 1.40A 2bfpC-2y5qA:
undetectable		 2bfpC-2y5qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		6 / 12 LEU A 110
ASN A 108
GLY A 107
ILE A  82
VAL A  91
ILE A  88
 None
 1.46A 3bvbB-2y5qA:
undetectable		 3bvbB-2y5qA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 LEU A 135
LEU A 204
VAL A 181
LEU A 169
 None
 0.67A 3g8iA-2y5qA:
undetectable		 3g8iA-2y5qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.91A 4wg0B-2y5qA:
undetectable
4wg0C-2y5qA:
undetectable
4wg0D-2y5qA:
undetectable		 4wg0B-2y5qA:
8.57
4wg0C-2y5qA:
8.57
4wg0D-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 223
LEU A 226
LEU A 237
ALA A 307
LEU A 235
 None
 1.07A 4wg0B-2y5qA:
undetectable
4wg0C-2y5qA:
undetectable
4wg0D-2y5qA:
undetectable		 4wg0B-2y5qA:
8.57
4wg0C-2y5qA:
8.57
4wg0D-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.78A 4wg0B-2y5qA:
undetectable
4wg0C-2y5qA:
undetectable		 4wg0B-2y5qA:
8.57
4wg0C-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.90A 4wg0D-2y5qA:
undetectable
4wg0E-2y5qA:
undetectable
4wg0F-2y5qA:
undetectable		 4wg0D-2y5qA:
8.57
4wg0E-2y5qA:
8.57
4wg0F-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 223
LEU A 226
LEU A 237
ALA A 307
LEU A 235
 None
 1.08A 4wg0D-2y5qA:
undetectable
4wg0E-2y5qA:
undetectable
4wg0F-2y5qA:
undetectable		 4wg0D-2y5qA:
8.57
4wg0E-2y5qA:
8.57
4wg0F-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		6 / 11 ALA A 307
LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 1.23A 4wg0C-2y5qA:
undetectable
4wg0D-2y5qA:
undetectable
4wg0E-2y5qA:
undetectable		 4wg0C-2y5qA:
8.57
4wg0D-2y5qA:
8.57
4wg0E-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.89A 4wg0F-2y5qA:
undetectable
4wg0G-2y5qA:
undetectable
4wg0H-2y5qA:
undetectable		 4wg0F-2y5qA:
8.57
4wg0G-2y5qA:
8.57
4wg0H-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 223
LEU A 226
LEU A 237
ALA A 307
LEU A 235
 None
 1.06A 4wg0F-2y5qA:
undetectable
4wg0G-2y5qA:
undetectable
4wg0H-2y5qA:
undetectable		 4wg0F-2y5qA:
8.57
4wg0G-2y5qA:
8.57
4wg0H-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		6 / 11 ALA A 307
LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 1.22A 4wg0E-2y5qA:
undetectable
4wg0F-2y5qA:
undetectable
4wg0G-2y5qA:
undetectable		 4wg0E-2y5qA:
8.57
4wg0F-2y5qA:
8.57
4wg0G-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.88A 4wg0H-2y5qA:
undetectable
4wg0I-2y5qA:
undetectable
4wg0J-2y5qA:
undetectable		 4wg0H-2y5qA:
8.57
4wg0I-2y5qA:
8.57
4wg0J-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ALA A 307
LEU A 235
LEU A 237
LEU A 223
LEU A 226
 None
 1.07A 4wg0G-2y5qA:
undetectable
4wg0H-2y5qA:
undetectable
4wg0I-2y5qA:
undetectable		 4wg0G-2y5qA:
8.57
4wg0H-2y5qA:
8.57
4wg0I-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.89A 4wg0G-2y5qA:
undetectable
4wg0H-2y5qA:
undetectable
4wg0I-2y5qA:
undetectable		 4wg0G-2y5qA:
8.57
4wg0H-2y5qA:
8.57
4wg0I-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.90A 4wg0J-2y5qA:
undetectable
4wg0K-2y5qA:
undetectable
4wg0L-2y5qA:
undetectable		 4wg0J-2y5qA:
8.57
4wg0K-2y5qA:
8.57
4wg0L-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.86A 4wg0I-2y5qA:
undetectable
4wg0J-2y5qA:
undetectable
4wg0K-2y5qA:
undetectable		 4wg0I-2y5qA:
8.57
4wg0J-2y5qA:
8.57
4wg0K-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 ASN A 261
LEU A 223
LEU A 226
LEU A 237
 None
 0.76A 4wg0L-2y5qA:
undetectable
4wg0M-2y5qA:
undetectable		 4wg0L-2y5qA:
8.57
4wg0M-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ALA A 307
LEU A 235
LEU A 237
LEU A 223
LEU A 226
 None
 1.04A 4wg0K-2y5qA:
undetectable
4wg0L-2y5qA:
undetectable
4wg0M-2y5qA:
undetectable		 4wg0K-2y5qA:
8.57
4wg0L-2y5qA:
8.57
4wg0M-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.84A 4wg0K-2y5qA:
undetectable
4wg0L-2y5qA:
undetectable
4wg0M-2y5qA:
undetectable		 4wg0K-2y5qA:
8.57
4wg0L-2y5qA:
8.57
4wg0M-2y5qA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 ASN A 108
LEU A 116
PHE A 104
 None
 0.81A 5dsgA-2y5qA:
undetectable		 5dsgA-2y5qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 10 LEU A 125
GLY A 123
LEU A 116
LEU A 119
THR A 101
 None
 1.08A 5o96G-2y5qA:
undetectable
5o96H-2y5qA:
undetectable		 5o96G-2y5qA:
22.35
5o96H-2y5qA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 ILE A 220
VAL A 202
LEU A 237
LEU A 213
LEU A 235
 None
 1.29A 5tiwA-2y5qA:
undetectable		 5tiwA-2y5qA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2y5q INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 LEU A  61
LEU A  97
PRO A  98
PHE A  48
THR A  42
 None
 1.21A 6debB-2y5qA:
undetectable		 6debB-2y5qA:
13.96