SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 268
LEU A 290
ILE A  13
PRO A 170
VAL A 162
 None
 1.34A 1hrkB-2y5wA:
2.6		 1hrkB-2y5wA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		5 / 12 GLY A 300
ASP A  11
GLY A  86
ILE A 306
ILE A  13
 None
 0.93A 1hshC-2y5wA:
undetectable		 1hshC-2y5wA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.15A 1p6kA-2y5wA:
undetectable		 1p6kA-2y5wA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.11A 1p6kB-2y5wA:
undetectable		 1p6kB-2y5wA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.15A 1rs6A-2y5wA:
undetectable		 1rs6A-2y5wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.09A 1rs6B-2y5wA:
undetectable		 1rs6B-2y5wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.07A 1rs7B-2y5wA:
undetectable		 1rs7B-2y5wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 7 TYR A 285
THR A  87
THR A 304
VAL A 271
 None
 1.02A 1tv8A-2y5wA:
undetectable		 1tv8A-2y5wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 5 PRO A 116
VAL A 119
ASN A 120
VAL A 186
 None
 1.05A 1z2bC-2y5wA:
undetectable		 1z2bC-2y5wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.15A 1zzqA-2y5wA:
undetectable		 1zzqA-2y5wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.11A 1zzqB-2y5wA:
undetectable		 1zzqB-2y5wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.11A 1zzuB-2y5wA:
undetectable		 1zzuB-2y5wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 265
ILE A 306
ILE A  13
ILE A 272
TYR A  91
 None
 1.41A 2efjA-2y5wA:
undetectable		 2efjA-2y5wA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 TYR A 285
THR A  87
THR A 304
VAL A 271
 None
 1.03A 2fb2A-2y5wA:
undetectable		 2fb2A-2y5wA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 7 TYR A 285
THR A  87
THR A 304
VAL A 271
 None
 1.03A 2fb2B-2y5wA:
undetectable		 2fb2B-2y5wA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		5 / 12 ALA A 274
LEU A 275
ALA A 276
THR A 332
ILE A 306
 None
 1.11A 2jjpA-2y5wA:
undetectable		 2jjpA-2y5wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		3 / 3 SER A 208
HIS A 100
ASP A 108
 None
ADP  A 600 (-3.6A)
None
 0.68A 2oxtA-2y5wA:
undetectable		 2oxtA-2y5wA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 268
LEU A 290
ILE A  13
PRO A 170
VAL A 162
 None
 1.34A 2pnjB-2y5wA:
undetectable		 2pnjB-2y5wA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 THR A 323
SER A 242
SER A  96
CYH A 309
 None
None
ADP  A 600 (-3.8A)
None
 1.24A 2xz5C-2y5wA:
undetectable
2xz5D-2y5wA:
undetectable		 2xz5C-2y5wA:
21.08
2xz5D-2y5wA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.32A 3n62A-2y5wA:
undetectable		 3n62A-2y5wA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.22A 3n62B-2y5wA:
undetectable		 3n62B-2y5wA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.31A 3n66B-2y5wA:
undetectable		 3n66B-2y5wA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		3 / 3 VAL A  58
VAL A  35
SER A  47
 None
 0.69A 3n8xB-2y5wA:
undetectable		 3n8xB-2y5wA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 6 VAL A 214
VAL A 139
ILE A 115
ARG A 150
 None
 1.01A 3pyyA-2y5wA:
undetectable		 3pyyA-2y5wA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 268
LEU A 290
ILE A  13
PRO A 170
VAL A 162
 None
 1.39A 3w1wB-2y5wA:
undetectable		 3w1wB-2y5wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 THR A 304
GLY A 299
ILE A  13
VAL A 333
 None
 0.98A 4e1vG-2y5wA:
undetectable		 4e1vG-2y5wA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 THR A 304
GLY A 299
ILE A  13
VAL A 333
 None
 0.98A 4e1vH-2y5wA:
undetectable		 4e1vH-2y5wA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		5 / 7 PRO A 116
VAL A 119
ASN A 120
VAL A 186
ILE A 190
 None
 1.35A 5bmvC-2y5wA:
undetectable		 5bmvC-2y5wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.35A 5vunB-2y5wA:
undetectable		 5vunB-2y5wA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2y5w KINESIN HEAVY CHAIN
(Drosophila
melanogaster) 		4 / 8 SER A 311
ARG A  20
PHE A  19
ASN A 316
 None
 1.33A 6auuB-2y5wA:
undetectable		 6auuB-2y5wA:
21.40