SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.28A 1os2A-2y6cA:
26.0		 1os2A-2y6cA:
53.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.21A 1os2D-2y6cA:
25.9		 1os2D-2y6cA:
53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 10 THR A 180
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 (-4.2A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.53A 1r55A-2y6cA:
8.5		 1r55A-2y6cA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.13A 1uttA-2y6cA:
26.0		 1uttA-2y6cA:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.20A 1utzA-2y6cA:
26.3		 1utzA-2y6cA:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.18A 1utzB-2y6cA:
26.1		 1utzB-2y6cA:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.35A 1y93A-2y6cA:
26.2		 1y93A-2y6cA:
53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.72A 2einN-2y6cA:
undetectable		 2einN-2y6cA:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.17A 2hu6A-2y6cA:
26.3		 2hu6A-2y6cA:
53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.46A 2jihA-2y6cA:
9.1		 2jihA-2y6cA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 8 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.21A 2jihB-2y6cA:
9.3		 2jihB-2y6cA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.47A 2ow9A-2y6cA:
25.2		 2ow9A-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.21A 2ow9B-2y6cA:
25.0		 2ow9B-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.25A 2ozrC-2y6cA:
25.6		 2ozrC-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.30A 2ozrD-2y6cA:
25.9		 2ozrD-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.30A 2ozrE-2y6cA:
25.6		 2ozrE-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 219
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.26A 2ozrF-2y6cA:
25.0		 2ozrF-2y6cA:
51.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 VAL A 152
ASP A 194
LEU A 225
ARG A 150
 None
CA  A1264 (-3.0A)
None
None
 1.17A 2ziaA-2y6cA:
2.3		 2ziaA-2y6cA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 183
GLU A 220
HIS A 223
 ZN  A1266 ( 3.3A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
 0.43A 3ba0A-2y6cA:
23.8		 3ba0A-2y6cA:
54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.75A 3bvdA-2y6cA:
undetectable		 3bvdA-2y6cA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.75A 3dtuA-2y6cA:
undetectable		 3dtuA-2y6cA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.76A 3dtuC-2y6cA:
undetectable		 3dtuC-2y6cA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.46A 3hy7A-2y6cA:
9.4		 3hy7A-2y6cA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.44A 3hy7B-2y6cA:
9.4		 3hy7B-2y6cA:
23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.20A 3kecA-2y6cA:
25.2		 3kecA-2y6cA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 219
GLU A 220
HIS A 223
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
 0.14A 3kecB-2y6cA:
24.8		 3kecB-2y6cA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.43A 3likA-2y6cA:
26.3		 3likA-2y6cA:
53.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.18A 3lilA-2y6cA:
26.5		 3lilA-2y6cA:
53.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.20A 3ljgA-2y6cA:
26.3		 3ljgA-2y6cA:
53.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.41A 3lkaA-2y6cA:
26.2		 3lkaA-2y6cA:
54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.76A 3s38A-2y6cA:
undetectable		 3s38A-2y6cA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.80A 3s3aA-2y6cA:
undetectable		 3s3aA-2y6cA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 LYS A 143
GLU A 144
TRP A 141
 None
 1.21A 3v4tH-2y6cA:
undetectable		 3v4tH-2y6cA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.74A 3wg7A-2y6cA:
undetectable		 3wg7A-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.73A 3x2qN-2y6cA:
undetectable		 3x2qN-2y6cA:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.46A 4a7bA-2y6cA:
25.6		 4a7bA-2y6cA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
 0.15A 4a7bB-2y6cA:
25.6		 4a7bB-2y6cA:
52.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 8 TYR A 116
ILE A 118
ILE A 161
ALA A 217
 None
 0.94A 4ou1A-2y6cA:
undetectable		 4ou1A-2y6cA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.19A 5n5jA-2y6cA:
26.5		 5n5jA-2y6cA:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.20A 5n5kA-2y6cA:
25.9		 5n5kA-2y6cA:
56.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 THR A 129
ASP A 131
ARG A 132
LEU A 133
 None
 1.43A 5tdmA-2y6cA:
undetectable		 5tdmA-2y6cA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 7 GLN A 260
GLY A 258
TYR A 215
ASP A 232
 None
 1.08A 5vlmE-2y6cA:
undetectable		 5vlmE-2y6cA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.72A 5w97a-2y6cA:
undetectable		 5w97a-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.71A 5x19N-2y6cA:
undetectable		 5x19N-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.71A 5x1bA-2y6cA:
undetectable		 5x1bA-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.69A 5x1bN-2y6cA:
undetectable		 5x1bN-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.73A 5x1fA-2y6cA:
undetectable		 5x1fA-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.66A 5x1fN-2y6cA:
undetectable		 5x1fN-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.76A 5xdqA-2y6cA:
undetectable		 5xdqA-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.77A 5xdqN-2y6cA:
undetectable		 5xdqN-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.74A 5xdxA-2y6cA:
undetectable		 5xdxA-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.73A 5xdxN-2y6cA:
undetectable		 5xdxN-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.74A 5zcoN-2y6cA:
undetectable		 5zcoN-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 183
HIS A 168
HIS A 196
PHE A 185
 ZN  A1266 ( 3.3A)
ZN  A1266 ( 3.2A)
ZN  A1266 (-3.0A)
None
 1.22A 5zrdC-2y6cA:
undetectable		 5zrdC-2y6cA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 183
HIS A 168
HIS A 196
PHE A 185
 ZN  A1266 ( 3.3A)
ZN  A1266 ( 3.2A)
ZN  A1266 (-3.0A)
None
 1.23A 5zrdD-2y6cA:
undetectable		 5zrdD-2y6cA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 TYR A 172
HIS A 183
PHE A 185
 None
ZN  A1266 ( 3.3A)
None
 0.35A 6esmA-2y6cA:
25.8		 6esmA-2y6cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.74A 6hu9a-2y6cA:
undetectable		 6hu9a-2y6cA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.76A 6hu9m-2y6cA:
undetectable		 6hu9m-2y6cA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 11 SER A 111
GLY A 193
GLY A 188
LEU A 191
ASP A 170
 None
CA  A1264 ( 4.5A)
None
None
ZN  A1266 ( 2.4A)
 1.29A 6i5zD-2y6cA:
undetectable		 6i5zD-2y6cA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.72A 6nmfA-2y6cA:
undetectable		 6nmfA-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.72A 6nmfN-2y6cA:
undetectable		 6nmfN-2y6cA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 229
HIS A 223
HIS A 219
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.76A 6nmpN-2y6cA:
undetectable		 6nmpN-2y6cA:
14.34