SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2y6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		5 / 12 LEU A 301
GLY A 300
GLN A 298
THR A 327
ILE A 359
 None
 1.39A 1z95A-2y6eA:
undetectable		 1z95A-2y6eA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		3 / 3 LEU A 479
PRO A 480
ARG A 779
 None
 0.63A 2qd4B-2y6eA:
undetectable		 2qd4B-2y6eA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		3 / 3 LEU A 479
PRO A 480
ARG A 779
 None
 0.48A 2qd5A-2y6eA:
undetectable		 2qd5A-2y6eA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		3 / 3 ALA A 371
VAL A 370
GLN A 361
 None
 0.43A 3of4B-2y6eA:
undetectable		 3of4B-2y6eA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		3 / 3 PRO A 796
ASP A 795
GLU A 793
 None
 0.60A 3v4tC-2y6eA:
0.1		 3v4tC-2y6eA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		4 / 6 ASP A 403
ASP A 449
ASN A 410
GLU A 407
 None
 1.30A 3vywA-2y6eA:
undetectable		 3vywA-2y6eA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		4 / 5 ASP A 403
ASP A 449
ASN A 410
GLU A 407
 None
 1.36A 3vywD-2y6eA:
undetectable		 3vywD-2y6eA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		5 / 12 ILE A 447
HIS A 406
LEU A 398
LEU A 401
GLY A 404
 None
 1.03A 4l9qB-2y6eA:
undetectable		 4l9qB-2y6eA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		5 / 12 LEU A 301
GLY A 300
GLN A 298
THR A 327
ILE A 359
 None
 1.41A 4okbA-2y6eA:
undetectable		 4okbA-2y6eA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		3 / 3 ARG A 923
ASP A 924
ARG A 922
 None
 0.68A 4wq4B-2y6eA:
undetectable		 4wq4B-2y6eA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		5 / 8 ILE A 868
CYH A 319
SER A 315
LEU A 398
LEU A 401
 None
None
CME  A 311 ( 4.7A)
None
None
 1.13A 4xtaB-2y6eA:
undetectable		 4xtaB-2y6eA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		5 / 11 LEU A 405
LEU A 402
LEU A 358
ILE A 359
LEU A 304
 None
 1.04A 4zowA-2y6eA:
undetectable		 4zowA-2y6eA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		5 / 9 LEU A 320
ILE A 359
ILE A 868
PHE A 919
VAL A 917
 None
 1.41A 5igzA-2y6eA:
undetectable		 5igzA-2y6eA:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		7 / 8 GLY A 303
LEU A 304
ASN A 314
SER A 315
GLN A 318
ALA A 884
PHE A 897
 None
None
CME  A 311 ( 4.7A)
CME  A 311 ( 4.7A)
None
None
None
 0.27A 5xu8A-2y6eA:
40.5		 5xu8A-2y6eA:
41.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		3 / 3 TYR A 863
PRO A 818
LEU A 821
 None
 0.77A 6beoA-2y6eA:
undetectable		 6beoA-2y6eA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		5 / 11 ASP A 367
ILE A 297
LEU A 301
LEU A 304
ILE A 359
 None
 1.30A 6fgcA-2y6eA:
undetectable		 6fgcA-2y6eA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4
(Homo
sapiens) 		5 / 5 ASN A 306
TYR A 874
GLY A 875
HIS A 881
ASP A 898
 CME  A 311 ( 3.8A)
None
None
CME  A 311 ( 4.1A)
None
 0.36A 6gh9A-2y6eA:
45.8		 6gh9A-2y6eA:
18.13